SNX17 and LRP2

Number of citations of the paper that reports this interaction (PMID 12169628)
26

Data Source:
BioGRID (pull down)

		SNX17	LRP2
Gene Name		sorting nexin 17	low density lipoprotein receptor-related protein 2
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Cytoplasmic Membrane-bounded Vesicle Cytoplasmic Vesicle Membrane Intracellular Membrane-bounded Organelle Protein Complex	Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Coated Pit Integral Component Of Membrane Apical Plasma Membrane Endocytic Vesicle Brush Border Membrane Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Protein Binding Protein C-terminus Binding Phosphatidylinositol Binding Low-density Lipoprotein Particle Receptor Binding	Calcium Ion Binding Protein Binding SH3 Domain Binding
	Biological Process	Cholesterol Catabolic Process Intracellular Protein Transport Receptor-mediated Endocytosis Signal Transduction Endosomal Transport Regulation Of Endocytosis	Retinoid Metabolic Process Protein Glycosylation Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Phototransduction, Visible Light Steroid Metabolic Process Cell Proliferation Forebrain Development Vitamin D Metabolic Process Small Molecule Metabolic Process
Pathways			Metabolism of lipids and lipoproteins Visual phototransduction Diseases associated with visual transduction Metabolism of steroid hormones and vitamin D Vitamin D (calciferol) metabolism Retinoid metabolism and transport
Drugs			Urokinase Insulin Regular Insulin, porcine Gentamicin
Diseases
GWAS			Anorexia nervosa ( 21079607) Urate levels ( 20139978)
Protein-Protein Interactions		10 interactors: APP HRAS LDLR LRP1 LRP2 LRP8 RLIM SELP SKIL VLDLR	48 interactors: ALB ANAPC10 ANKRA2 ANKS1B APBA2 APBB1 APOB APOE APOH APP ATN1 CLU CUBN DAB1 DAB2 DLG1 DLG2 DLG3 DLG4 GC GIPC1 GPRASP1 INS ITGB1BP1 LCN2 LDLRAP1 LPA LPL LRP2BP LRPAP1 MAGI1 MAPK8IP1 MAPK8IP2 MDK NOS1AP PIP5K1C PLAU RBP1 SCGB1A1 SCN3A SERPINE1 SLC9A3 SNX17 SYNJ2BP TG THBS1 TLN1 TTR
Entrez ID		9784	4036
HPRD ID		05812	02509
Ensembl ID		ENSG00000115234	ENSG00000081479
Uniprot IDs		B4DQ37 B4DTB8 Q15036	P98164 Q7Z5C0 Q7Z5C1
PDB IDs		3FOG 3LUI 4GXB	2M0P
Enriched GO Terms of Interacting Partners?		Endocytosis Response To Light Stimulus Vesicle-mediated Transport Response To Radiation Phototransduction, Visible Light Retinoid Metabolic Process Steroid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Detection Of Light Stimulus Cholesterol Metabolic Process Isoprenoid Metabolic Process Alcohol Metabolic Process Receptor-mediated Endocytosis Sterol Metabolic Process Detection Of Abiotic Stimulus Response To External Stimulus Response To Abiotic Stimulus Reelin-mediated Signaling Pathway Positive Regulation Of Cell Projection Organization Lipid Metabolic Process Nervous System Development Blood Coagulation Hemostasis Central Nervous System Development System Development Regulation Of Cell Projection Organization Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Regulation Of Cellular Component Organization Regulation Of Neuron Differentiation Detection Of Stimulus Regulation Of Body Fluid Levels Behavior Wound Healing Multicellular Organismal Development Positive Regulation Of Neuron Projection Development Plasma Lipoprotein Particle Clearance Anatomical Structure Development Negative Regulation Of Gene Expression Transport Response To Wounding Regulation Of Neurogenesis Learning Or Memory Signal Transduction Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Wound Healing Brain Development	Response To Wounding Regulation Of Catalytic Activity Transport Cell Communication Endocytosis Response To External Stimulus Signaling Receptor Clustering Blood Coagulation Negative Regulation Of Cellular Metabolic Process Hemostasis Vesicle-mediated Transport Cellular Localization Negative Regulation Of Protein Metabolic Process Receptor Localization To Synapse Regulation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Wound Healing Regulation Of Signal Transduction Receptor-mediated Endocytosis Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Signaling Regulation Of Cellular Process Regulation Of Metabolic Process Negative Regulation Of Intracellular Signal Transduction Platelet Degranulation Locomotion Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Lipid Metabolic Process Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Body Fluid Levels Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Steroid Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Secretion By Cell Positive Regulation Of Protein Metabolic Process Protein Localization To Synapse Movement Of Cell Or Subcellular Component Signal Transduction System Development Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Catalytic Activity Regulation Of Phosphorylation
Tagcloud ?		1x10 a2ic aa2t abi analyzer bait bigdye ccdc32 gal gal4 heterotetramer lexa ligated monocyte ncbi nlm ogdh papd4 pbtm116 plasmin prey prism procathepsin ready reconstituting resultant rps2 terminator zbtb4	adenosine bioinformatics ciliary consequences damaging dnaaf1 eventual exome exploration harbouring heterozygote hyperprolactinaemia hypopituitarism inexpensive inosine intriguing itp mendelian morbid novo obesity ontology overrepresented teenager trios triphosphate ucp2 variants wes
Tagcloud (Difference) ?		1x10 a2ic aa2t abi analyzer bait bigdye ccdc32 gal gal4 heterotetramer lexa ligated monocyte ncbi nlm ogdh papd4 pbtm116 plasmin prey prism procathepsin ready reconstituting resultant rps2 terminator zbtb4	adenosine bioinformatics ciliary consequences damaging dnaaf1 eventual exome exploration harbouring heterozygote hyperprolactinaemia hypopituitarism inexpensive inosine intriguing itp mendelian morbid novo obesity ontology overrepresented teenager trios triphosphate ucp2 variants wes
Tagcloud (Intersection) ?