RIMS2 and RAB27A

Number of citations of the paper that reports this interaction (PMID 12578829)
33

Data Source:
HPRD (in vivo, in vitro)

		RIMS2	RAB27A
Gene Name		regulating synaptic membrane exocytosis 2	RAB27A, member RAS oncogene family
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cell Junction Presynaptic Membrane Presynaptic Active Zone Extracellular Vesicular Exosome	Photoreceptor Outer Segment Lysosome Late Endosome Golgi Apparatus Apical Plasma Membrane Secretory Granule Dendrite Secretory Granule Membrane Multivesicular Body Membrane Melanosome Extracellular Vesicular Exosome Exocytic Vesicle
	Molecular Function	Protein Binding Rab GTPase Binding Ion Channel Binding Metal Ion Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Myosin V Binding
	Biological Process	Intracellular Protein Transport Positive Regulation Of Gene Expression Calcium Ion-dependent Exocytosis Regulation Of Exocytosis CAMP-mediated Signaling Insulin Secretion Regulation Of Membrane Potential Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Excitatory Postsynaptic Membrane Potential	Protein Targeting Intracellular Protein Transport Exocytosis Vesicle Docking Involved In Exocytosis Blood Coagulation Protein Secretion Positive Regulation Of Gene Expression Antigen Processing And Presentation Melanocyte Differentiation Melanosome Localization Melanosome Transport Rab Protein Signal Transduction Multivesicular Body Organization Cytotoxic T Cell Degranulation Natural Killer Cell Degranulation Cellular Protein Metabolic Process Positive Regulation Of Exocytosis Synaptic Vesicle Transport Positive Regulation Of Phagocytosis Multivesicular Body Sorting Pathway Complement-dependent Cytotoxicity Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Constitutive Secretory Pathway Exosomal Secretion
Pathways			Peptide hormone metabolism Insulin processing
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: ABCA1 CACNA1S RAB27A RAB3A RAB3B RAB3C RAB3D RAB8A RABAC1 RAPGEF4 RPH3AL YWHAH	28 interactors: ADRB2 APP C14orf1 COPS6 EEF1A1 EXPH5 GDF9 GDI1 GZMB KIAA1377 LRIF1 MLPH MYO5A MYRIP RABGGTB RBM48 RIMS1 RIMS2 RPH3A RPH3AL STX1A SYTL1 SYTL2 SYTL3 SYTL4 SYTL5 UNC13D ZBTB16
Entrez ID		9699	5873
HPRD ID		09436	04845
Ensembl ID			ENSG00000069974
Uniprot IDs		Q9UQ26	A2RU94 P51159
PDB IDs		1V27 1WFG
Enriched GO Terms of Interacting Partners?		Protein Secretion Regulation Of Exocytosis Secretion By Cell Rab Protein Signal Transduction Vesicle Docking Involved In Exocytosis Exocytosis Secretion Regulation Of Vesicle-mediated Transport Vesicle Docking Membrane Docking Synaptic Vesicle Transport Protein Transport Establishment Of Protein Localization Synaptic Vesicle Exocytosis Regulation Of Cellular Localization Regulation Of Secretion Protein Localization Establishment Of Vesicle Localization Vesicle Localization Establishment Of Localization In Cell Ras Protein Signal Transduction Vesicle-mediated Transport Intracellular Protein Transport Neurotransmitter Secretion Intracellular Transport Cellular Localization Small GTPase Mediated Signal Transduction Establishment Of Organelle Localization Regulation Of Neurotransmitter Levels Neurotransmitter Transport Positive Regulation Of Transport Organelle Localization Cellular Protein Localization Cell-cell Signaling Transport Positive Regulation Of Regulated Secretory Pathway Synaptic Transmission Intracellular Signal Transduction Peptidyl-cysteine Methylation Regulation Of Regulated Secretory Pathway Positive Regulation Of Exocytosis Regulation Of Synaptic Transmission Response To Stimulus Positive Regulation Of Secretion Endomembrane System Organization Signal Transduction Regulation Of Synaptic Plasticity Signaling Cell Communication Vesicle Organization	Exocytosis Secretion By Cell Intracellular Transport Secretion Cellular Protein Localization Establishment Of Localization In Cell Cellular Localization Protein Transport Intracellular Protein Transport Establishment Of Protein Localization Protein Localization Vesicle-mediated Transport Regulation Of Secretion Regulation Of Cellular Localization Regulation Of Exocytosis Positive Regulation Of Secretion Transport Positive Regulation Of Exocytosis Positive Regulation Of Transport Regulation Of Vesicle-mediated Transport Regulation Of Establishment Of Protein Localization Multivesicular Body Sorting Pathway Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Membrane Potential Calcium Ion-dependent Exocytosis Regulation Of Protein Localization Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Protein Transport Positive Regulation Of Protein Secretion Regulation Of Protein Secretion Regulation Of Excitatory Postsynaptic Membrane Potential Vesicle Localization Regulation Of Postsynaptic Membrane Potential Regulation Of Inhibitory Postsynaptic Membrane Potential Regulation Of Hormone Secretion Neurotransmitter Secretion Regulation Of Signaling Membrane Depolarization Glutamate Secretion Positive Regulation Of Protein Transport Regulation Of Neurotransmitter Levels Membrane Hyperpolarization Melanocyte Differentiation Neurotransmitter Transport Melanosome Localization Visual Perception Sensory Perception Of Light Stimulus Insulin Secretion Organelle Localization
Tagcloud ?			adenocarcinoma aggressive benign cancerous carcinomas deadly ductal exosome gtpases hypothesized immunohistochemistry implicated invasion invasive malignancies member microarray microenvironment modulating pancreatic pdac regulating represent secretion tissues tp53 trafficking vesicle
Tagcloud (Difference) ?			adenocarcinoma aggressive benign cancerous carcinomas deadly ductal exosome gtpases hypothesized immunohistochemistry implicated invasion invasive malignancies member microarray microenvironment modulating pancreatic pdac regulating represent secretion tissues tp53 trafficking vesicle
Tagcloud (Intersection) ?