RIMS2 and RAB3C

Number of citations of the paper that reports this interaction (PMID 12578829)
33

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		RIMS2	RAB3C
Gene Name		regulating synaptic membrane exocytosis 2	RAB3C, member RAS oncogene family
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cell Junction Presynaptic Membrane Presynaptic Active Zone Extracellular Vesicular Exosome	Endosome Cytosol Plasma Membrane Synaptic Vesicle Secretory Granule Membrane Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Rab GTPase Binding Ion Channel Binding Metal Ion Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Myosin V Binding
	Biological Process	Intracellular Protein Transport Positive Regulation Of Gene Expression Calcium Ion-dependent Exocytosis Regulation Of Exocytosis CAMP-mediated Signaling Insulin Secretion Regulation Of Membrane Potential Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Excitatory Postsynaptic Membrane Potential	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Protein Secretion Synaptic Vesicle Exocytosis Regulation Of Exocytosis Antigen Processing And Presentation Rab Protein Signal Transduction Protein Localization To Plasma Membrane
Pathways
Drugs
Diseases
GWAS			Breast cancer ( 23535729)
Protein-Protein Interactions		12 interactors: ABCA1 CACNA1S RAB27A RAB3A RAB3B RAB3C RAB3D RAB8A RABAC1 RAPGEF4 RPH3AL YWHAH	3 interactors: FKBP2 RIMS2 RPH3AL
Entrez ID		9699	115827
HPRD ID		09436	06704
Ensembl ID			ENSG00000152932
Uniprot IDs		Q9UQ26	Q96E17
PDB IDs		1V27 1WFG
Enriched GO Terms of Interacting Partners?		Protein Secretion Regulation Of Exocytosis Secretion By Cell Rab Protein Signal Transduction Vesicle Docking Involved In Exocytosis Exocytosis Secretion Regulation Of Vesicle-mediated Transport Vesicle Docking Membrane Docking Synaptic Vesicle Transport Protein Transport Establishment Of Protein Localization Synaptic Vesicle Exocytosis Regulation Of Cellular Localization Regulation Of Secretion Protein Localization Establishment Of Vesicle Localization Vesicle Localization Establishment Of Localization In Cell Ras Protein Signal Transduction Vesicle-mediated Transport Intracellular Protein Transport Neurotransmitter Secretion Intracellular Transport Cellular Localization Small GTPase Mediated Signal Transduction Establishment Of Organelle Localization Regulation Of Neurotransmitter Levels Neurotransmitter Transport Positive Regulation Of Transport Organelle Localization Cellular Protein Localization Cell-cell Signaling Transport Positive Regulation Of Regulated Secretory Pathway Synaptic Transmission Intracellular Signal Transduction Peptidyl-cysteine Methylation Regulation Of Regulated Secretory Pathway Positive Regulation Of Exocytosis Regulation Of Synaptic Transmission Response To Stimulus Positive Regulation Of Secretion Endomembrane System Organization Signal Transduction Regulation Of Synaptic Plasticity Signaling Cell Communication Vesicle Organization	Regulation Of Exocytosis Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Exocytosis Regulation Of Vesicle-mediated Transport Calcium Ion-dependent Exocytosis Of Neurotransmitter Secretion By Cell Regulation Of Inhibitory Postsynaptic Membrane Potential Regulation Of Secretion Secretion CAMP-mediated Signaling Cyclic-nucleotide-mediated Signaling Positive Regulation Of Excitatory Postsynaptic Membrane Potential Intracellular Protein Transport Membrane Hyperpolarization Positive Regulation Of Membrane Potential Insulin Secretion Regulation Of Cellular Localization Calcium Ion-dependent Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Chaperone-mediated Protein Folding Peptide Hormone Secretion Peptide Secretion Regulation Of Excitatory Postsynaptic Membrane Potential Cellular Protein Localization Regulation Of Postsynaptic Membrane Potential Protein Transport Protein Peptidyl-prolyl Isomerization Vesicle-mediated Transport Hormone Secretion Establishment Of Protein Localization Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Hormone Transport Intracellular Transport Peptide Transport Neurotransmitter Secretion Membrane Depolarization Protein Secretion Amide Transport Regulation Of Neurotransmitter Levels Second-messenger-mediated Signaling Protein Localization Establishment Of Localization In Cell Neurotransmitter Transport Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Protein Secretion Glucose Homeostasis
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