UBE3C and TLK1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		UBE3C	TLK1
Gene Name		ubiquitin protein ligase E3C	tousled-like kinase 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Proteasome Complex Intracellular Nucleus Cytoplasm	Nucleus
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity	Protein Serine/threonine Kinase Activity ATP Binding
	Biological Process	Protein Polyubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Regulation Of Chromatin Assembly Or Disassembly Protein Phosphorylation Intracellular Protein Transport Cellular Response To DNA Damage Stimulus Cell Cycle Chromatin Modification Intracellular Signal Transduction
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Quantitative traits ( 19197348) Response to citalopram treatment ( 19846067)	Menopause (age at onset) ( 22267201)
Protein-Protein Interactions		10 interactors: APP CAND2 GOLGA2 MTA2 PSMC5 PSMD2 TLK1 UBC UBE2D1 UBE2L3	13 interactors: ASF1A ASF1B AURKA CHEK1 HIST1H1A LUZP4 MBP NBN SNAP23 TLK2 TPM3 UBE3C YWHAE
Entrez ID		9690	9874
HPRD ID		15604	12232
Ensembl ID		ENSG00000009335	ENSG00000198586
Uniprot IDs		Q15386	Q9UKI8
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Ubiquitination Protein Polyubiquitination Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Cellular Protein Modification Process Cell Cycle Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Proteolysis Involved In Cellular Protein Catabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Cell Cycle Process Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Transferase Activity Cellular Protein Catabolic Process Cell Cycle Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Positive Regulation Of Cellular Protein Metabolic Process Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Proteasomal Protein Catabolic Process Cell Cycle Phase Transition Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint	Chromosome Organization Chromatin Organization Organelle Organization Chromatin Modification DNA Conformation Change DNA Replication-dependent Nucleosome Assembly Positive Regulation Of Gene Expression, Epigenetic G2/M Transition Of Mitotic Cell Cycle Nucleosome Assembly Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Protein Complex Assembly DNA Packaging Histone Phosphorylation DNA Replication-independent Nucleosome Assembly G2 DNA Damage Checkpoint Substantia Nigra Development Cellular Macromolecular Complex Assembly Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Process Cell Cycle Phase Transition Regulation Of Centrosome Cycle Cell Cycle Neural Nucleus Development Mitotic Cell Cycle Response To Stress Negative Regulation Of Spindle Checkpoint Cellular Response To Stress Cellular Response To DNA Damage Stimulus Regulation Of Organelle Organization Midbrain Development Regulation Of Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Spindle Assembly Involved In Female Meiosis I Regulation Of Heart Rate By Hormone Histone H3-T11 Phosphorylation Negative Regulation Of Peptidyl-serine Dephosphorylation Negative Regulation Of Cell Cycle Cell Cycle Process Reproduction Defense Response To Nematode Spindle Assembly Involved In Meiosis Peptidyl-serine Phosphorylation Cellular Component Assembly Regulation Of Cellular Component Organization Regulation Of Mitotic Nuclear Division Regulation Of Cellular Protein Metabolic Process Spindle Stabilization
Tagcloud ?		aberrantly aforementioned aurkb bcrp bortezomib ccnb1 cd138 cdc2 cenp centrosome downregulate entity epc1 evidences g2 immunomodulatory incurable initiating lenalidomide mdr1 myeloma organs polycomb possess proteasome psma5 sp upregulated works	asymmetric belonging cloned coefficient crystallization crystals cubic diffracting diffraction evolutionarily hetero homo homogeneity i4122 localize matthews namely oligomers p213 purification segregation solvent synchrotron tetragonal threonine tlk2 tlks tousled yielded
Tagcloud (Difference) ?		aberrantly aforementioned aurkb bcrp bortezomib ccnb1 cd138 cdc2 cenp centrosome downregulate entity epc1 evidences g2 immunomodulatory incurable initiating lenalidomide mdr1 myeloma organs polycomb possess proteasome psma5 sp upregulated works	asymmetric belonging cloned coefficient crystallization crystals cubic diffracting diffraction evolutionarily hetero homo homogeneity i4122 localize matthews namely oligomers p213 purification segregation solvent synchrotron tetragonal threonine tlk2 tlks tousled yielded
Tagcloud (Intersection) ?