ACY1 and TTC1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ACY1	TTC1
Gene Name		aminoacylase 1	tetratricopeptide repeat domain 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome	Cytoplasm Peroxisomal Membrane
	Molecular Function	Aminoacylase Activity Metallopeptidase Activity Metal Ion Binding	Protein Binding Unfolded Protein Binding
	Biological Process	Proteolysis Cellular Amino Acid Metabolic Process Xenobiotic Metabolic Process Small Molecule Metabolic Process	Protein Folding
Pathways		Aflatoxin activation and detoxification Biological oxidations Metabolic disorders of biological oxidation enzymes Defective ACY1 causes encephalopathy
Drugs		L-Aspartic Acid
Diseases
GWAS
Protein-Protein Interactions		6 interactors: APP NPM1 NUDT1 POT1 TERF1 TTC1	17 interactors: ACY1 CRY2 GNA15 GNAI2 GNAQ GNAS HRAS HSPA1A HSPA4 HSPA8 NDE1 RNF41 SH3BP4 SOX5 SPP1 SREBF2 TGFBR1
Entrez ID		95	7265
HPRD ID		00092	11881
Ensembl ID		ENSG00000243989	ENSG00000113312
Uniprot IDs		Q03154	Q99614
PDB IDs		1Q7L
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Catalytic Activity Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Transferase Activity DNA Metabolic Process Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Telomere Maintenance Cell Aging Regulation Of Cell Cycle Process Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of DNA Strand Elongation Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Positive Regulation Of Mitotic Cell Cycle Regulation Of DNA Replication DNA Protection Synaptic Growth At Neuromuscular Junction Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Cellular Component Assembly Regulation Of Microtubule Cytoskeleton Organization Collateral Sprouting In Absence Of Injury Telomeric Loop Formation Age-dependent Telomere Shortening DGTP Catabolic Process DATP Catabolic Process Regulation Of Ribonuclease Activity Regulation Of Endodeoxyribonuclease Activity Telomere Formation Via Telomerase Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Microtubule-based Process Negative Regulation Of Cellular Metabolic Process Telomere Maintenance Via Telomere Shortening DGTP Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Organelle Organization Regulation Of Cell Cycle Regulation Of Chromosome Organization Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Mitotic Cell Cycle Phase Transition	Cellular Response To Stimulus Response To Stimulus Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Response To Organic Substance Wound Healing Positive Regulation Of Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Response To Stress Regulation Of Cell Differentiation Response To Wounding Blood Coagulation Platelet Activation Hemostasis Activation Of MAPKK Activity Phospholipase C-activating Dopamine Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Growth Regulation Of Phosphorus Metabolic Process Regulation Of Body Fluid Levels G-protein Coupled Acetylcholine Receptor Signaling Pathway Regulation Of Growth Generation Of Neurons Neurogenesis Negative Regulation Of Cell Proliferation Cell Activation Regulation Of Cell Growth Protein Refolding Regulation Of Catalytic Activity Response To Unfolded Protein Post-embryonic Development Locomotion Negative Regulation Of Catalytic Activity Regulation Of Metabolic Process Negative Regulation Of Cell Growth Regulation Of Cellular Response To Heat Regulation Of Myeloid Cell Differentiation Negative Regulation Of GTPase Activity Regulation Of Signal Transduction Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Catalytic Activity Skeletal System Development Regulation Of Gene Expression Nervous System Development Activation Of Phospholipase C Activity Regulation Of Signaling Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Positive Regulation Of Phospholipase C Activity
Tagcloud ?		acylamino aminoacylase aminohydrolase approximate assignment autosomal chromosome chromosomes conserved electrophoretic eliminating galactosidase gangliosidosis glb1 gm1 hamster hybrids inbred linkage mammals map q21 segment segregating somatic tf transferrin translocations
Tagcloud (Difference) ?		acylamino aminoacylase aminohydrolase approximate assignment autosomal chromosome chromosomes conserved electrophoretic eliminating galactosidase gangliosidosis glb1 gm1 hamster hybrids inbred linkage mammals map q21 segment segregating somatic tf transferrin translocations
Tagcloud (Intersection) ?