ZFYVE9 and LRP12

Number of citations of the paper that reports this interaction (PMID 12809483)
4

Data Source:
HPRD (in vivo, two hybrid)

		ZFYVE9	LRP12
Gene Name		zinc finger, FYVE domain containing 9	low density lipoprotein receptor-related protein 12
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Early Endosome Early Endosome Membrane	Integral Component Of Plasma Membrane Coated Pit Integral Component Of Membrane
	Molecular Function	Protein Binding 1-phosphatidylinositol Binding Serine-type Peptidase Activity Metal Ion Binding	Low-density Lipoprotein Receptor Activity Protein Binding
	Biological Process	Proteolysis Endocytosis Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly SMAD Protein Import Into Nucleus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway	Endocytosis Receptor-mediated Endocytosis Signal Transduction Regulation Of Growth
Pathways			Visual phototransduction Diseases associated with visual transduction Retinoid metabolism and transport
Drugs
Diseases
GWAS			Glaucoma (primary open-angle) ( 22570617) Vascular endothelial growth factor levels ( 21757650)
Protein-Protein Interactions		38 interactors: ANKLE2 BAG6 BMP4 CHD6 CLTC CTNNB1 DAZAP2 EIF4G1 ERBB2IP ETS2 FAM46A FHL2 JUP LRP12 NIT1 NUP155 PML PPP1CA PPP1CB PPP1CC PPP2R1A RBBP6 RHOT2 RNF11 RNPEP SCYL2 SMAD2 SMAD3 SPG20 ST7 SUMF2 SUPT5H SVEP1 TGFBR1 TGFBR2 UBC UBXN11 ZMYND8	6 interactors: ACTN2 GNB2L1 MYOT NMRK2 SNAPIN ZFYVE9
Entrez ID		9372	29967
HPRD ID		04782	17447
Ensembl ID		ENSG00000157077	ENSG00000147650
Uniprot IDs		O95405	Q59H02 Q9Y561
PDB IDs		1DEV 1MK2 4BKW
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Common-partner SMAD Protein Phosphorylation Cell Cycle Trachea Formation Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Embryonic Skeletal System Morphogenesis Entrainment Of Circadian Clock By Photoperiod Embryonic Cranial Skeleton Morphogenesis Cellular Response To Organic Substance Response To Organic Substance Photoperiodism Entrainment Of Circadian Clock Embryonic Skeletal System Development Lens Development In Camera-type Eye Cell Cycle Process Regulation Of Growth Signal Transduction Trachea Morphogenesis Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Embryonic Foregut Morphogenesis Regulation Of Gene Expression Foregut Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Lung Development Negative Regulation Of Growth Negative Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Morphogenesis Respiratory Tube Development Glycogen Metabolic Process Regulation Of Chondrocyte Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Signaling Skeletal System Morphogenesis Tube Morphogenesis Negative Regulation Of Biosynthetic Process Positive Regulation Of Cell Death	Positive Regulation Of Late Endosome To Lysosome Transport Positive Regulation Of CAMP Catabolic Process Terminal Button Organization Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Autophagic Vacuole Maturation Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Muscle Contraction Microspike Assembly Regulation Of Cellular Localization Negative Regulation Of Oxidative Stress-induced Neuron Death Muscle System Process Negative Regulation Of Protein Localization To Cell Surface SMAD Protein Import Into Nucleus Positive Regulation Of Protein Homooligomerization Positive Regulation Of Gastrulation Negative Regulation Of Hydrogen Peroxide-induced Cell Death Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Mitochondrial Depolarization Synaptic Vesicle Fusion To Presynaptic Membrane Exocytosis Regulation Of Hydrogen Peroxide-induced Cell Death SMAD Protein Complex Assembly Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Phagocytosis Synaptic Vesicle Maturation Negative Regulation Of Potassium Ion Transmembrane Transport Vesicle-mediated Transport Negative Regulation Of Transport Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Mitochondrial Depolarization Positive Regulation Of Protein Oligomerization Regulation Of Protein Localization To Cell Surface Anterograde Synaptic Vesicle Transport Melanosome Organization Pigment Granule Organization Negative Regulation Of Potassium Ion Transport Negative Regulation Of Myoblast Differentiation Secretion By Cell Negative Regulation Of Oxidative Stress-induced Cell Death Regulation Of Protein Oligomerization Regulation Of Potassium Ion Transmembrane Transporter Activity Anterograde Axon Cargo Transport NAD Biosynthetic Process Regulation Of Response To Reactive Oxygen Species Positive Regulation Of Potassium Ion Transport Viral Process Endosome To Lysosome Transport Positive Regulation Of Embryonic Development Actin-myosin Filament Sliding
Tagcloud ?		calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes	as1 atoh7 beadchip cav1 cav2 cdkn2b cnvs cyp1b1 duplications fndc3b galc gas7 glaugen human660w interrogated kilobases merit myoc neighbor optn penncnv poag quad six1 six6 srbd1 tmco1 wdr36 zfpm2
Tagcloud (Difference) ?		calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes	as1 atoh7 beadchip cav1 cav2 cdkn2b cnvs cyp1b1 duplications fndc3b galc gas7 glaugen human660w interrogated kilobases merit myoc neighbor optn penncnv poag quad six1 six6 srbd1 tmco1 wdr36 zfpm2
Tagcloud (Intersection) ?