LONP1 and MAST1

Number of citations of the paper that reports this interaction (PMID 21163940)
13

Data Source:
BioGRID (two hybrid)

		LONP1	MAST1
Gene Name		lon peptidase 1, mitochondrial	microtubule associated serine/threonine kinase 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Membrane Mitochondrial Nucleoid	Cytoplasm Cytoskeleton Plasma Membrane
	Molecular Function	Single-stranded DNA Binding Single-stranded RNA Binding ATP-dependent Peptidase Activity Serine-type Endopeptidase Activity Protein Binding ATP Binding ADP Binding Sequence-specific DNA Binding G-quadruplex DNA Binding DNA Polymerase Binding Mitochondrial Light Strand Promoter Anti-sense Binding Mitochondrial Heavy Strand Promoter Anti-sense Binding Mitochondrial Light Strand Promoter Sense Binding Mitochondrial Heavy Strand Promoter Sense Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Mitochondrial Genome Maintenance Response To Hypoxia Misfolded Or Incompletely Synthesized Protein Catabolic Process Mitochondrion Organization Aging Response To Hormone Response To Aluminum Ion Mitochondrial DNA Metabolic Process Cellular Response To Oxidative Stress Chaperone-mediated Protein Complex Assembly Protein Homooligomerization Proteolysis Involved In Cellular Protein Catabolic Process Oxidation-dependent Protein Catabolic Process Regulation Of Mitochondrial DNA Replication	Protein Phosphorylation Cytoskeleton Organization Intracellular Signal Transduction
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: A2M APOE CDC37 CYP2C8 ECSIT IFIT3 IFIT5 LOXL4 MAST1 RNF32	37 interactors: A2M AP1M2 APOE APP BLMH CDK5 CYP2C8 CYP2C9 DNAJB1 ECSIT EGFR ELAVL3 EXOC6 EXOSC1 FBXL12 FBXW4 GCDH IFIT3 IFIT5 LONP1 LOXL4 MGEA5 NOS3 PAXIP1 PRAM1 PRDX2 PSEN2 PTEN RAB3A RAB3D RAD23A RNF32 RNLS RPP30 SNTA1 SNTB2 STAMBPL1
Entrez ID		9361	22983
HPRD ID		05689	17469
Ensembl ID		ENSG00000196365	ENSG00000105613
Uniprot IDs		B3KPH8 F5GZ27 P36776 Q8N8K8	Q9Y2H9
PDB IDs		2X36	2M9X 3PS4
Enriched GO Terms of Interacting Partners?		Regulation Of Oxidoreductase Activity Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Dendritic Spine Maintenance Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Postsynaptic Membrane Organization Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Complement Activation, Lectin Pathway Negative Regulation Of Presynaptic Membrane Organization Positive Regulation Of Presynaptic Membrane Organization Positive Regulation Of Phospholipid Efflux Negative Regulation Of Cholesterol Biosynthetic Process Regulation Of Postsynaptic Membrane Organization Very-low-density Lipoprotein Particle Clearance Maintenance Of Location In Cell Defense Response To Virus Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Cholesterol Efflux N-methyl-D-aspartate Receptor Clustering Regulation Of Tau-protein Kinase Activity Regulation Of Presynaptic Membrane Organization Negative Regulation Of Dendritic Spine Development High-density Lipoprotein Particle Clearance Positive Regulation Of Inclusion Body Assembly Regulation Of Beta-amyloid Clearance Very-low-density Lipoprotein Particle Remodeling Innate Immune Response Positive Regulation Of Cholesterol Esterification Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering High-density Lipoprotein Particle Assembly Response To External Stimulus Positive Regulation Of Phospholipid Transport Omega-hydroxylase P450 Pathway Chylomicron Remnant Clearance Regulation Of Cholesterol Esterification Peripheral Nervous System Axon Regeneration Triglyceride-rich Lipoprotein Particle Remodeling Cellular Response To Interferon-alpha Regulation Of Innate Immune Response Negative Regulation Of Beta-amyloid Formation CGMP-mediated Signaling Exit From Mitosis Low-density Lipoprotein Particle Remodeling Cholesterol Catabolic Process Response To Virus Negative Regulation Of Cholesterol Transport Establishment Of Localization In Cell	Catabolic Process Synapse Organization Negative Regulation Of Protein Metabolic Process Response To Stress Negative Regulation Of Cellular Protein Metabolic Process Response To Abiotic Stimulus Negative Regulation Of Presynaptic Membrane Organization Regulation Of Synaptic Plasticity Regulation Of Synaptic Transmission Regulation Of Oxidoreductase Activity Synapse Assembly Exocytosis Regulation Of Cellular Protein Metabolic Process Axon Development Response To Stimulus Regulation Of Presynaptic Membrane Organization Regulation Of Nitric-oxide Synthase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Dendritic Spine Development Learning Or Memory Regulation Of Proteolysis Regulation Of Dendritic Spine Development Negative Regulation Of Cell Death Cognition Omega-hydroxylase P450 Pathway Synaptic Vesicle Exocytosis Anatomical Structure Morphogenesis Secretion By Cell Vesicle Docking Involved In Exocytosis Axonogenesis Positive Regulation Of Exocytosis Neuron Projection Development Vesicle-mediated Transport Glial Cell Differentiation Protein Metabolic Process Establishment Of Protein Localization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Morphogenesis Involved In Neuron Differentiation Negative Regulation Of Neuron Differentiation Membrane Organization Oxidative Demethylation Protein Catabolic Process Establishment Of Vesicle Localization Oligodendrocyte Differentiation Positive Regulation Of Catalytic Activity Regulation Of ERBB Signaling Pathway Vesicle Docking Regulation Of Cellular Amino Acid Metabolic Process Endothelial Cell Migration Vesicle Localization
Tagcloud ?		2161c aggregated amish ancestral anomalies arg721gly auricular backgrounds canada codas come exome german homo homohexameric localize lymphoblastoid mennonite mtdna oligomerizes pocket proteostasis recombinantly sanger spare substitutions swiss swollen
Tagcloud (Difference) ?		2161c aggregated amish ancestral anomalies arg721gly auricular backgrounds canada codas come exome german homo homohexameric localize lymphoblastoid mennonite mtdna oligomerizes pocket proteostasis recombinantly sanger spare substitutions swiss swollen
Tagcloud (Intersection) ?