HELB and POLA2

Number of citations of the paper that reports this interaction (PMID 12181327)
11

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		HELB	POLA2
Gene Name		helicase (DNA) B	polymerase (DNA directed), alpha 2, accessory subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Alpha DNA Polymerase:primase Complex Cytoplasm	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytoplasm
	Molecular Function	ATP-dependent RNA Helicase Activity ATP Binding Single-stranded DNA-dependent ATP-dependent DNA Helicase Activity ATP-dependent 5'-3' DNA Helicase Activity Poly(A) RNA Binding	Molecular_function DNA Binding DNA-directed DNA Polymerase Activity Protein Heterodimerization Activity
	Biological Process	DNA Replication DNA Replication, Synthesis Of RNA Primer RNA Processing DNA Duplex Unwinding	Protein Import Into Nucleus, Translocation G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process
Pathways			Activation of the pre-replicative complex Extension of Telomeres Activation of the pre-replicative complex Leading Strand Synthesis DNA strand elongation Polymerase switching DNA replication initiation Telomere Maintenance G1/S Transition Mitotic G1-G1/S phases E2F mediated regulation of DNA replication Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Processive synthesis on the lagging strand DNA Replication Pre-Initiation M/G1 Transition Telomere C-strand (Lagging Strand) Synthesis S Phase Cell Cycle, Mitotic Removal of the Flap Intermediate Inhibition of replication initiation of damaged DNA by RB1/E2F1
Drugs			Dacarbazine
Diseases
GWAS
Protein-Protein Interactions		3 interactors: POLA1 POLA2 RPA1	31 interactors: AKTIP APP ASCC2 ATP5C1 CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 NHP2L1 NR4A1 PARP1 POLA1 PRPF38A RBM23 SETDB1 STK40 ULK2 XPNPEP1
Entrez ID		92797	23649
HPRD ID		09979	10160
Ensembl ID		ENSG00000127311
Uniprot IDs		Q8NG08	Q14181
PDB IDs			2KEB 4E2I
Enriched GO Terms of Interacting Partners?		Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Telomere Maintenance DNA-dependent DNA Replication G1/S Transition Of Mitotic Cell Cycle DNA Recombination Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Replication DNA Replication Initiation Mitotic Cell Cycle Process Cellular Homeostasis Mitotic Cell Cycle DNA Biosynthetic Process Chromosome Organization Cell Cycle Process DNA Metabolic Process Double-strand Break Repair Cell Cycle Homeostatic Process Leading Strand Elongation DNA Recombinase Assembly Lagging Strand Elongation DNA Replication, Synthesis Of RNA Primer DNA Repair Nucleotide-excision Repair, DNA Gap Filling Nucleotide-excision Repair, DNA Damage Removal Organelle Organization Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Nonhomologous End Joining Cellular Macromolecule Biosynthetic Process Cellular Response To DNA Damage Stimulus Protein Import Into Nucleus, Translocation Regulation Of Cellular Response To Heat Macromolecule Biosynthetic Process Homeostasis Of Number Of Cells Within A Tissue Transcription-coupled Nucleotide-excision Repair Nucleobase-containing Compound Metabolic Process Mismatch Repair Base-excision Repair Cellular Response To Heat Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process	RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Developmental Growth Growth MRNA Metabolic Process DNA Replication, Synthesis Of RNA Primer Regulation Of Growth Cellular Response To Reactive Oxygen Species Regulation Of Binding Regulation Of Receptor Activity Organ Development Metabolic Process RNA Processing Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Development Positive Regulation Of Programmed Cell Death Developmental Growth Involved In Morphogenesis Regulation Of Protein Binding Positive Regulation Of Cell Death Histone H3-K9 Modification Negative Regulation Of Epithelial Cell Differentiation Cellular Protein Modification Process Cellular Protein Metabolic Process Chromosome Organization Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Hepatocyte Differentiation Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Hsp90 Deacetylation Response To Oxidative Stress MRNA Processing RNA Biosynthetic Process Cochlea Development Response To Reactive Oxygen Species Negative Regulation Of Cell Differentiation Cellular Response To Oxidative Stress Lung Alveolus Development Macroautophagy Regulation Of Cell Differentiation System Development Cellular Response To Hydrogen Peroxide Positive Regulation Of Chaperone-mediated Protein Complex Assembly Leading Strand Elongation Synaptic Growth At Neuromuscular Junction Polyubiquitinated Misfolded Protein Transport
Tagcloud ?			beadchip ca125 carboplatin cdkn1b chek2 ck7 cyfra21 cytokinesis deserve exceptional fancd2 illumina krt7 lig3 mesothelioma nt5c obscure pemetrexed phosphorylase platinum pold1 prpf19 recq5 sensitize smrp sparcl1 transendothelial ts tymp
Tagcloud (Difference) ?			beadchip ca125 carboplatin cdkn1b chek2 ck7 cyfra21 cytokinesis deserve exceptional fancd2 illumina krt7 lig3 mesothelioma nt5c obscure pemetrexed phosphorylase platinum pold1 prpf19 recq5 sensitize smrp sparcl1 transendothelial ts tymp
Tagcloud (Intersection) ?