POLA2 and ASCC2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		POLA2	ASCC2
Gene Name		polymerase (DNA directed), alpha 2, accessory subunit	activating signal cointegrator 1 complex subunit 2
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytoplasm
	Molecular Function	Molecular_function DNA Binding DNA-directed DNA Polymerase Activity Protein Heterodimerization Activity
	Biological Process	Protein Import Into Nucleus, Translocation G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways		Activation of the pre-replicative complex Extension of Telomeres Activation of the pre-replicative complex Leading Strand Synthesis DNA strand elongation Polymerase switching DNA replication initiation Telomere Maintenance G1/S Transition Mitotic G1-G1/S phases E2F mediated regulation of DNA replication Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Processive synthesis on the lagging strand DNA Replication Pre-Initiation M/G1 Transition Telomere C-strand (Lagging Strand) Synthesis S Phase Cell Cycle, Mitotic Removal of the Flap Intermediate Inhibition of replication initiation of damaged DNA by RB1/E2F1
Drugs		Dacarbazine
Diseases
GWAS
Protein-Protein Interactions		31 interactors: AKTIP APP ASCC2 ATP5C1 CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 NHP2L1 NR4A1 PARP1 POLA1 PRPF38A RBM23 SETDB1 STK40 ULK2 XPNPEP1	38 interactors: ASS1 CKAP4 CUTC DEAF1 EEF1D ELAC2 FAF1 FBP1 FUNDC2 GADD45A GFER GNL3 GTF3C1 IGSF9 IMMT JUN KDM1A LPL MED31 MYH9 OLA1 PCBD2 PIK3CD PIN4 PJA1 POLA2 POLDIP2 RADIL RELA RNF11 RPA1 RPLP1 SNRPB SNW1 SRF TBC1D17 TRIP4 URM1
Entrez ID		23649	84164
HPRD ID		10160	16515
Ensembl ID			ENSG00000100325
Uniprot IDs		Q14181	Q9H1I8
PDB IDs		2KEB 4E2I	2DI0
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Developmental Growth Growth MRNA Metabolic Process DNA Replication, Synthesis Of RNA Primer Regulation Of Growth Cellular Response To Reactive Oxygen Species Regulation Of Binding Regulation Of Receptor Activity Organ Development Metabolic Process RNA Processing Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Development Positive Regulation Of Programmed Cell Death Developmental Growth Involved In Morphogenesis Regulation Of Protein Binding Positive Regulation Of Cell Death Histone H3-K9 Modification Negative Regulation Of Epithelial Cell Differentiation Cellular Protein Modification Process Cellular Protein Metabolic Process Chromosome Organization Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Hepatocyte Differentiation Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Hsp90 Deacetylation Response To Oxidative Stress MRNA Processing RNA Biosynthetic Process Cochlea Development Response To Reactive Oxygen Species Negative Regulation Of Cell Differentiation Cellular Response To Oxidative Stress Lung Alveolus Development Macroautophagy Regulation Of Cell Differentiation System Development Cellular Response To Hydrogen Peroxide Positive Regulation Of Chaperone-mediated Protein Complex Assembly Leading Strand Elongation Synaptic Growth At Neuromuscular Junction Polyubiquitinated Misfolded Protein Transport	Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Myeloid Leukocyte Differentiation RNA Metabolic Process Nitrogen Compound Metabolic Process Myeloid Cell Differentiation Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation By Host Of Viral Transcription Leukocyte Differentiation RNA Biosynthetic Process Metabolic Process Response To Abiotic Stimulus Mitochondrion Organization Hemopoiesis Monocyte Differentiation Transcription, DNA-templated Telomere Maintenance Via Semi-conservative Replication Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Platelet Formation Protein Tetramerization Response To Radiation Platelet Morphogenesis Immune System Development Macromolecule Biosynthetic Process Telomere Maintenance Via Recombination Regulation Of Histone H3-K4 Methylation Nuclear DNA Replication Positive Regulation Of Transcription, DNA-templated Response To CAMP Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Response To Drug DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Response To Stress Gene Expression Blood Vessel Endothelial Cell Migration Interaction With Symbiont Learning Membrane Protein Proteolysis Aging Regulation Of Cell Proliferation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Organophosphorus Positive Regulation Of Macromolecule Biosynthetic Process
Tagcloud ?		beadchip ca125 carboplatin cdkn1b chek2 ck7 cyfra21 cytokinesis deserve exceptional fancd2 illumina krt7 lig3 mesothelioma nt5c obscure pemetrexed phosphorylase platinum pold1 prpf19 recq5 sensitize smrp sparcl1 transendothelial ts tymp
Tagcloud (Difference) ?		beadchip ca125 carboplatin cdkn1b chek2 ck7 cyfra21 cytokinesis deserve exceptional fancd2 illumina krt7 lig3 mesothelioma nt5c obscure pemetrexed phosphorylase platinum pold1 prpf19 recq5 sensitize smrp sparcl1 transendothelial ts tymp
Tagcloud (Intersection) ?