GPR50 and MTNR1B

Number of citations of the paper that reports this interaction (PMID 16778767)
48

Data Source:
HPRD (in vivo, in vitro)

		GPR50	MTNR1B
Gene Name		G protein-coupled receptor 50	melatonin receptor 1B
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	G-protein Coupled Receptor Activity Protein Binding Melatonin Receptor Activity Identical Protein Binding	G-protein Coupled Receptor Activity Protein Binding Melatonin Receptor Activity
	Biological Process	G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Synaptic Transmission Glucose Homeostasis Regulation Of Insulin Secretion
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Ramelteon Melatonin Agomelatine
Diseases
GWAS			Adverse response to radiation therapy ( 23719583) Diabetes (gestational) ( 22233651) Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) Fasting plasma glucose ( 19060907 19060909 19651812 22508271) Glycated hemoglobin levels ( 20858683) Glycemic traits ( 23575436) Insomnia (caffeine-induced) ( 22754043) Metabolic syndrome ( 22399527) Metabolic traits ( 19060910) Metabolite levels ( 21909109 22286219) Obesity-related traits ( 23251661) Type 2 diabetes ( 20581827)
Protein-Protein Interactions		4 interactors: ARRB1 MTNR1A MTNR1B ZNF572	20 interactors: CANX COPA CTNND1 FLNA GNAI1 GNAI2 GNAI3 GNB1 GNB4 GPR50 HNRNPA0 HSPA5 IRS4 ITM2C MTNR1A PDIA6 PI4KA PPM1G VPS35 YWHAQ
Entrez ID		9248	4544
HPRD ID		02194	02882
Ensembl ID		ENSG00000102195	ENSG00000134640
Uniprot IDs		Q13585	P49286
PDB IDs
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Regulation Of Hormone Secretion Positive Regulation Of Histone H4 Acetylation Regulation Of Protein Secretion G-protein Coupled Receptor Internalization Negative Regulation Of Interleukin-8 Production Stress Fiber Assembly Regulation Of Histone H4 Acetylation Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of CGMP Biosynthetic Process Positive Regulation Of Receptor Internalization Positive Regulation Of CGMP Metabolic Process Positive Regulation Of Histone Acetylation Regulation Of CGMP Biosynthetic Process Regulation Of Protein Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Peptidyl-lysine Acetylation Regulation Of Secretion Positive Regulation Of Protein Acetylation Regulation Of Establishment Of Protein Localization Regulation Of Receptor Internalization Regulation Of CGMP Metabolic Process	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Signaling Cell Communication Substantia Nigra Development Signal Transduction Wound Healing Vesicle-mediated Transport Neural Nucleus Development Cell Activation Response To Wounding G-protein Coupled Receptor Signaling Pathway Midbrain Development G-protein Coupled Acetylcholine Receptor Signaling Pathway Cell-cell Signaling Cellular Response To Stimulus Synaptic Transmission Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Response To Stimulus Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Dopamine Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Peptide Hormone Cellular Response To Glucagon Stimulus Negative Regulation Of Nucleotide Metabolic Process Membrane Organization Response To Peptide Vesicle Organization Vesicle Fusion Regulation Of Protein Folding In Endoplasmic Reticulum Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Response To Glucagon Positive Regulation Of Nuclease Activity Regulation Of Adenylate Cyclase Activity Regulation Of Signal Transduction Regulation Of Cellular Process Regulation Of Cyclase Activity Platelet Degranulation Secretion Cerebellum Structural Organization Negative Regulation Of Late Endosome To Lysosome Transport Organelle Fusion Cellular Response To Peptide Hormone Stimulus
Tagcloud ?		12q23 12q24 14q22 15q11 18p11 22q13 chmp1 citron cux2 drd1 fkbp5 flj32356 g72 gabra5 gchi grm3 grm4 htr2a httlpr impa2 mlc1 napg ncam1 pdlim5 period3 slc12a6 syngr1 timeless tph2	china cnki database electronic embase employed estimate gdm genetic gestational inclusion inconclusive infrastructure irs1 medline melatonin mellitus polymorphisms pubmed risks rs10830963 rs1387153 rs1801278 searched ten value variant variants
Tagcloud (Difference) ?		12q23 12q24 14q22 15q11 18p11 22q13 chmp1 citron cux2 drd1 fkbp5 flj32356 g72 gabra5 gchi grm3 grm4 htr2a httlpr impa2 mlc1 napg ncam1 pdlim5 period3 slc12a6 syngr1 timeless tph2	china cnki database electronic embase employed estimate gdm genetic gestational inclusion inconclusive infrastructure irs1 medline melatonin mellitus polymorphisms pubmed risks rs10830963 rs1387153 rs1801278 searched ten value variant variants
Tagcloud (Intersection) ?