GPR50 and MTNR1A

Number of citations of the paper that reports this interaction (PMID 16778767)
48

Data Source:
HPRD (in vivo, in vitro)

		GPR50	MTNR1A
Gene Name		G protein-coupled receptor 50	melatonin receptor 1A
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	G-protein Coupled Receptor Activity Protein Binding Melatonin Receptor Activity Identical Protein Binding	Protein Binding Melatonin Receptor Activity Hormone Binding Organic Cyclic Compound Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Mating Behavior Circadian Rhythm Positive Regulation Of CGMP Biosynthetic Process
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Ramelteon Melatonin Agomelatine
Diseases
GWAS			Obesity ( 21552555)
Protein-Protein Interactions		4 interactors: ARRB1 MTNR1A MTNR1B ZNF572	26 interactors: CALR CANX CNP DPM1 EEF1G FLNA GNA11 GNA13 GNAI1 GNAI2 GNAI3 GNB1 GNB4 GPR50 HNRNPA0 HSPA5 IRS4 LRRC59 MTNR1B PDIA6 PGRMC1 RAB10 RAC1 RAP1A TMEM33 VAPB
Entrez ID		9248	4543
HPRD ID		02194	02812
Ensembl ID		ENSG00000102195	ENSG00000168412
Uniprot IDs		Q13585	P48039
PDB IDs
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Regulation Of Hormone Secretion Positive Regulation Of Histone H4 Acetylation Regulation Of Protein Secretion G-protein Coupled Receptor Internalization Negative Regulation Of Interleukin-8 Production Stress Fiber Assembly Regulation Of Histone H4 Acetylation Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of CGMP Biosynthetic Process Positive Regulation Of Receptor Internalization Positive Regulation Of CGMP Metabolic Process Positive Regulation Of Histone Acetylation Regulation Of CGMP Biosynthetic Process Regulation Of Protein Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Peptidyl-lysine Acetylation Regulation Of Secretion Positive Regulation Of Protein Acetylation Regulation Of Establishment Of Protein Localization Regulation Of Receptor Internalization Regulation Of CGMP Metabolic Process	Platelet Activation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Blood Coagulation Hemostasis Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Signaling Cell Communication Response To Stimulus G-protein Coupled Receptor Signaling Pathway Signal Transduction Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Response To Organic Substance Positive Regulation Of Nuclease Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Kinase Activity Vesicle-mediated Transport Positive Regulation Of Transferase Activity Response To Stress Synaptic Transmission Cell-cell Signaling Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Stimulus Cellular Response To Topologically Incorrect Protein Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Kinase Activity Dopamine Receptor Signaling Pathway Substantia Nigra Development Cellular Response To Organic Substance Response To Unfolded Protein Regulation Of Kinase Activity Membrane Organization Positive Regulation Of Phosphorylation Response To Endoplasmic Reticulum Stress Cell Surface Receptor Signaling Pathway Neural Nucleus Development Positive Regulation Of Protein Modification Process Ras Protein Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Response To Peptide Hormone Midbrain Development G-protein Coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		12q23 12q24 14q22 15q11 18p11 22q13 chmp1 citron cux2 drd1 fkbp5 flj32356 g72 gabra5 gchi grm3 grm4 htr2a httlpr impa2 mlc1 napg ncam1 pdlim5 period3 slc12a6 syngr1 timeless tph2
Tagcloud (Difference) ?		12q23 12q24 14q22 15q11 18p11 22q13 chmp1 citron cux2 drd1 fkbp5 flj32356 g72 gabra5 gchi grm3 grm4 htr2a httlpr impa2 mlc1 napg ncam1 pdlim5 period3 slc12a6 syngr1 timeless tph2
Tagcloud (Intersection) ?