ACVR2A and SYNJ2BP

Number of citations of the paper that reports this interaction (PMID 11882656)
9

Data Source:
HPRD (two hybrid, in vitro)

		ACVR2A	SYNJ2BP
Gene Name		activin A receptor, type IIA	synaptojanin 2 binding protein
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Inhibin-betaglycan-ActRII Complex Receptor Complex	Mitochondrion Cell Surface Integral Component Of Mitochondrial Outer Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Coreceptor Activity Activin-activated Receptor Activity Growth Factor Binding PDZ Domain Binding Inhibin Binding Protein Self-association Metal Ion Binding Activin Binding	Protein C-terminus Binding Type II Activin Receptor Binding
	Biological Process	Gastrulation With Mouth Forming Second Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Spermatogenesis Determination Of Left/right Symmetry Mesoderm Development Anterior/posterior Pattern Specification Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Signal Transduction By Phosphorylation Positive Regulation Of Bone Mineralization BMP Signaling Pathway Regulation Of BMP Signaling Pathway Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Sperm Ejaculation Penile Erection Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Osteoblast Differentiation Embryonic Skeletal System Development Regulation Of Nitric-oxide Synthase Activity Sertoli Cell Proliferation Cellular Response To BMP Stimulus	Positive Regulation Of Receptor Internalization Negative Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Intracellular Distribution Of Mitochondria Positive Regulation Of Protein Localization To Cell Surface
Pathways		Signaling by Activin Regulation of signaling by NODAL Signaling by BMP Signaling by NODAL
Drugs
Diseases
GWAS		Response to statin therapy ( 20339536) Urate levels ( 23263486)
Protein-Protein Interactions		17 interactors: ACVRL1 BMP10 BMP6 BMP7 ENG ERBB2IP GDF2 GDF5 GDF9 IGSF1 INHBA INHBB INHBC MAGI2 SYNJ2BP TCTEX1D4 TGFBR3	10 interactors: ACTB ACVR2A ACVR2B APP LRP1 LRP2 LRP8 RALBP1 SYNJ2 USHBP1
Entrez ID		92	55333
HPRD ID		00025	15455
Ensembl ID		ENSG00000121989
Uniprot IDs		B4DWQ2 P27037	P57105
PDB IDs		3Q4T 3SOC 4ASX	2ENO 2JIK 2JIN
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Protein Signal Transduction BMP Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Growth Positive Regulation Of Signal Transduction Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Activin Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Phosphorylation Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Cell Development Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Proliferation Signal Transduction Negative Regulation Of Cell Migration Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Motility Cell Differentiation Negative Regulation Of Cell Proliferation Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Component Movement Signaling Cell Communication Negative Regulation Of Locomotion Regulation Of Protein Metabolic Process Negative Regulation Of Epithelial Cell Proliferation Tissue Development Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Migration Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Growth Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Response To Organic Substance Cellular Response To Stimulus Response To Growth Factor	Endocytosis Phototransduction, Visible Light Positive Regulation Of Activin Receptor Signaling Pathway Retinoid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Response To Light Stimulus Phototransduction Detection Of Light Stimulus Isoprenoid Metabolic Process Response To External Stimulus Response To Radiation Regulation Of Activin Receptor Signaling Pathway Detection Of Abiotic Stimulus Signal Transduction Lipid Metabolic Process Activin Receptor Signaling Pathway Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Signaling Vesicle-mediated Transport Cell Communication Steroid Metabolic Process Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Brain Development System Development Head Development Mating Gastrulation With Mouth Forming Second Regulation Of Protein Tyrosine Kinase Activity Alcohol Metabolic Process Organ Development Cellular Response To Stimulus Receptor-mediated Endocytosis Artery Development Regulation Of Signaling Cellular Lipid Metabolic Process Central Nervous System Development Cell Surface Receptor Signaling Pathway Multicellular Organismal Development Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Anatomical Structure Development Ammon Gyrus Development Beta-amyloid Clearance Regulation Of Protein Phosphorylation Transport Blood Coagulation
Tagcloud ?		5p alters applying bmp bmp1a cleaves cluster copyright dies1 furin impairs interferes mapk3 micrornas mineralization mir osteoblast osteoblasts protected reprogramming reserved rights ski smad smad5 smurf1 systematically tgfbr3 zfp423
Tagcloud (Difference) ?		5p alters applying bmp bmp1a cleaves cluster copyright dies1 furin impairs interferes mapk3 micrornas mineralization mir osteoblast osteoblasts protected reprogramming reserved rights ski smad smad5 smurf1 systematically tgfbr3 zfp423
Tagcloud (Intersection) ?