ACVR2A and IGSF1

Number of citations of the paper that reports this interaction (PMID 11266516)
5

Data Source:
HPRD (in vivo)

		ACVR2A	IGSF1
Gene Name		activin A receptor, type IIA	immunoglobulin superfamily, member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Inhibin-betaglycan-ActRII Complex Receptor Complex	Extracellular Region Membrane Integral Component Of Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Coreceptor Activity Activin-activated Receptor Activity Growth Factor Binding PDZ Domain Binding Inhibin Binding Protein Self-association Metal Ion Binding Activin Binding	Receptor Activity Protein Binding Coreceptor Activity Inhibin Binding
	Biological Process	Gastrulation With Mouth Forming Second Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Spermatogenesis Determination Of Left/right Symmetry Mesoderm Development Anterior/posterior Pattern Specification Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Signal Transduction By Phosphorylation Positive Regulation Of Bone Mineralization BMP Signaling Pathway Regulation Of BMP Signaling Pathway Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Sperm Ejaculation Penile Erection Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Osteoblast Differentiation Embryonic Skeletal System Development Regulation Of Nitric-oxide Synthase Activity Sertoli Cell Proliferation Cellular Response To BMP Stimulus	Regulation Of Transcription, DNA-templated Signal Transduction
Pathways		Signaling by Activin Regulation of signaling by NODAL Signaling by BMP Signaling by NODAL
Drugs
Diseases
GWAS		Response to statin therapy ( 20339536) Urate levels ( 23263486)
Protein-Protein Interactions		17 interactors: ACVRL1 BMP10 BMP6 BMP7 ENG ERBB2IP GDF2 GDF5 GDF9 IGSF1 INHBA INHBB INHBC MAGI2 SYNJ2BP TCTEX1D4 TGFBR3	8 interactors: ACVR1 ACVR1B ACVR2A ACVR2B HECTD1 IGF1 INHBB RANBP10
Entrez ID		92	3547
HPRD ID		00025	02138
Ensembl ID		ENSG00000121989	ENSG00000147255
Uniprot IDs		B4DWQ2 P27037	Q8N6C5
PDB IDs		3Q4T 3SOC 4ASX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Protein Signal Transduction BMP Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Growth Positive Regulation Of Signal Transduction Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Activin Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Phosphorylation Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Cell Development Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Proliferation Signal Transduction Negative Regulation Of Cell Migration Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Motility Cell Differentiation Negative Regulation Of Cell Proliferation Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Component Movement Signaling Cell Communication Negative Regulation Of Locomotion Regulation Of Protein Metabolic Process Negative Regulation Of Epithelial Cell Proliferation Tissue Development Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Migration Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Growth Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Response To Organic Substance Cellular Response To Stimulus Response To Growth Factor	Activin Receptor Signaling Pathway Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Activin Receptor Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Positive Regulation Of Protein Phosphorylation Regulation Of Osteoblast Differentiation Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Positive Regulation Of Bone Mineralization Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Biomineral Tissue Development Regulation Of Ossification Positive Regulation Of Protein Metabolic Process Gastrulation With Mouth Forming Second Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Signal Transduction By Phosphorylation Developmental Process Involved In Reproduction Regulation Of Phosphorus Metabolic Process Regulation Of Bone Mineralization BMP Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Cell Differentiation Tissue Development Regulation Of Signaling Determination Of Left/right Symmetry Determination Of Bilateral Symmetry Tube Morphogenesis Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Epithelium Development Mesoderm Development Embryo Development Regulation Of Protein Metabolic Process Positive Regulation Of Erythrocyte Differentiation Reproductive Process Gastrulation Embryonic Morphogenesis System Development Positive Regulation Of Cellular Metabolic Process Tube Development Development Of Primary Sexual Characteristics Regulation Of Cell Differentiation Regulation Of Erythrocyte Differentiation
Tagcloud ?		5p alters applying bmp bmp1a cleaves cluster copyright dies1 furin impairs interferes mapk3 micrornas mineralization mir osteoblast osteoblasts protected reprogramming reserved rights ski smad smad5 smurf1 systematically tgfbr3 zfp423	boys ch congenital definitive exome greatly harbored heterozygous hypothyroidism japanese lacks missense mothers nonsense prolactin q645x r1189x sequencing severely stature superfamily t3 t4 thereafter thrive traffic unexplained v1082e
Tagcloud (Difference) ?		5p alters applying bmp bmp1a cleaves cluster copyright dies1 furin impairs interferes mapk3 micrornas mineralization mir osteoblast osteoblasts protected reprogramming reserved rights ski smad smad5 smurf1 systematically tgfbr3 zfp423	boys ch congenital definitive exome greatly harbored heterozygous hypothyroidism japanese lacks missense mothers nonsense prolactin q645x r1189x sequencing severely stature superfamily t3 t4 thereafter thrive traffic unexplained v1082e
Tagcloud (Intersection) ?