TMSB10 and ALAS1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		TMSB10	ALAS1
Gene Name		thymosin beta 10	5-aminolevulinate synthase 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Actin Monomer Binding	5-aminolevulinate Synthase Activity Pyridoxal Phosphate Binding
	Biological Process	Actin Filament Organization Sequestering Of Actin Monomers	Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Organelle Organization Mitochondrion Organization Cellular Lipid Metabolic Process Small Molecule Metabolic Process
Pathways			PPARA activates gene expression Heme biosynthesis Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Metabolism of porphyrins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis Mitochondrial biogenesis
Drugs			Pyridoxal Phosphate Glycine
Diseases
GWAS			Bipolar disorder ( 21926972)
Protein-Protein Interactions		7 interactors: ALAS1 KRTAP9-2 POT1 TERF1 TERF2 TERF2IP TMOD1	40 interactors: BCL7A C2orf42 C8orf33 CCHCR1 CDC73 CDK5 CDKN1A CERK DUSP19 EP400 FAM127C GNL3L KLHL35 LONRF1 MTFR2 NUDT3 PIK3CB PLAU POLDIP2 PPL RAP1B SH2D4A SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564
Entrez ID		9168	211
HPRD ID		01779	00505
Ensembl ID		ENSG00000034510	ENSG00000023330
Uniprot IDs		P63313	P13196 Q5JAM2
PDB IDs
Enriched GO Terms of Interacting Partners?		Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Telomere Capping Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of Chromosome Organization Telomeric Loop Formation Age-dependent Telomere Shortening Negative Regulation Of DNA Replication Telomere Maintenance Via Telomere Shortening Protection From Non-homologous End Joining At Telomere DNA Replication Regulation Of Organelle Organization Negative Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome, Telomeric Region Replicative Cell Aging Negative Regulation Of Telomerase Activity Positive Regulation Of Telomere Maintenance Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Telomere Maintenance Via Telomerase Regulation Of DNA Replication Regulation Of Telomerase Activity Organelle Organization Negative Regulation Of DNA Biosynthetic Process Regulation Of Cellular Component Organization Protein Localization To Chromosome Chromosome Organization DNA Metabolic Process Regulation Of DNA Biosynthetic Process Positive Regulation Of Organelle Organization Cell Aging Homeostatic Process Positive Regulation Of DNA Strand Elongation Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of DNA Metabolic Process Telomere Formation Via Telomerase Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Helicase Activity Positive Regulation Of Telomerase Activity Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process	Sequestering Of Actin Monomers Blood Coagulation Hemostasis Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity
Tagcloud ?		acidic arrest chemoresistance coil coiled diminished dramatically ep2 g2 hela inactivated mediating mmp9 mtacc mtacc3 overexpressed paclitaxel pecam plk ppia prostaglandin proteome rab31 synergistic tacc tacc3 transactivation transforming uhrf1	adequate arf1 candidate eif2b1 fbxw2 genorm gusb housekeeping hprt1 hysterectomy ideal leiomyoma menopausal menstrual mrpl19 myometrial myometrium normalization normfinder phases proliferative pum1 regardless secretory softwares standards taqman trim27 ube2d2
Tagcloud (Difference) ?		acidic arrest chemoresistance coil coiled diminished dramatically ep2 g2 hela inactivated mediating mmp9 mtacc mtacc3 overexpressed paclitaxel pecam plk ppia prostaglandin proteome rab31 synergistic tacc tacc3 transactivation transforming uhrf1	adequate arf1 candidate eif2b1 fbxw2 genorm gusb housekeeping hprt1 hysterectomy ideal leiomyoma menopausal menstrual mrpl19 myometrial myometrium normalization normfinder phases proliferative pum1 regardless secretory softwares standards taqman trim27 ube2d2
Tagcloud (Intersection) ?