ARHGEF1 and TCF4

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ARHGEF1	TCF4
Gene Name		Rho guanine nucleotide exchange factor (GEF) 1	transcription factor 4
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Nucleus Transcription Factor Complex
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Poly(A) RNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase Recruiting Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription TFIIB-class Binding Transcription Factor Activity TFIIB-class Transcription Factor Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein C-terminus Binding Protein Heterodimerization Activity E-box Binding
	Biological Process	Rho Protein Signal Transduction Cell Proliferation Positive Regulation Of Rho GTPase Activity Termination Of G-protein Coupled Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Axonogenesis Negative Regulation Of Axonogenesis	DNA-templated Transcription, Initiation Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein-DNA Complex Assembly
Pathways		Signaling by GPCR GPCR downstream signaling Signalling by NGF Axonal growth inhibition (RHOA activation) p75NTR regulates axonogenesis G alpha (12/13) signalling events p75 NTR receptor-mediated signalling	CDO in myogenesis Myogenesis
Drugs
Diseases
GWAS			Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Diabetic retinopathy ( 21441570) Fuchs's corneal dystrophy ( 20825314) Obesity (early onset extreme) ( 23563609) Schizophrenia ( 21926974 19571808 19571811 22688191 23894747) Sclerosing cholangitis and ulcerative colitis (combined) ( 22821403)
Protein-Protein Interactions		11 interactors: ATR CD44 CNKSR1 CSNK1E GNA13 HRAS PRKCA RAP1A RHOA SREBF2 TCF4	173 interactors: AES AQP1 AR ARHGEF1 ARMC7 ASCL1 ASCL3 ASCL4 ASPSCR1 ATP6V1B2 BCAS2 BCL2L2 BZRAP1 C19orf66 C1orf109 C9orf171 CABP5 CALM1 CALM2 CALM3 CCDC101 CDC73 CDKN1A CDKN2C CHAF1A CHCHD2 CHIC2 CKS1B CTBP1 CTNNB1 DDX6 DEF6 DGCR6 DMRT3 EFHC1 EIF4E2 EIF4EBP1 EP300 EPB41L3 EPHB6 EXOSC1 FAH FAM124B FAM74A4 FERD3L FLAD1 FLNA FRS3 GEM GLRX3 GNG10 GOLGA8EP GOLGA8F GORASP2 GTF3C5 GUCD1 HAND2 HAT1 HBP1 HIC1 HSPB7 ID1 ID2 ID3 ID4 INS JUN JUP KCTD14 KLC3 KLHL32 LASP1 LENG1 LGALS14 LMO1 LMO4 LNPEP LYL1 MAD2L2 MAGOHB MAPKBP1 MATN3 MEMO1 MEN1 MLLT6 MORN4 MRFAP1L1 MRPL10 MSC MSRB3 MVP MYO5B MYOD1 NCK2 NDOR1 NEK6 NEK8 NEU4 NEUROD1 NEUROG1 NME7 NMUR2 NOL9 NR2C2AP NR4A1 NUDT10 ORC4 OSGIN1 OTUD4 PARK2 PARP1 PATE1 PBLD PIN1 PLEKHN1 POLR1A POLR1C PPIA PPIL1 PPP1R18 PRKAA2 PRKAB2 PSEN1 PSMA1 PSMG2 PTF1A PTGER3 RAB41 RABIF RECK RELA REXO1L6P RNF138 RSPH14 RUNX1T1 SCOC SEC14L4 SIGLEC6 SLC39A13 SLC4A1AP SMCP SMOC1 SPATC1L SPG21 SRSF2 STAMBPL1 STK16 STX11 SUMO1 SZT2 TAL1 TAL2 TAPBPL TCEA2 TCF3 TCL1A TLE1 TMEM213 TRAPPC2L TSSC4 TSSK3 TWIST2 TXNL4B USP4 UTP23 VPS28 XRCC5 XRCC6 ZDHHC24 ZNF124 ZNF205-AS1 ZNF417 ZNF587
Entrez ID		9138	6925
HPRD ID		03511	03780
Ensembl ID		ENSG00000076928	ENSG00000196628
Uniprot IDs		Q6NX52 Q92888	B3KVA4 E9PH57 H3BTP3 P15884
PDB IDs		1IAP 1SHZ 3AB3 3ODO 3ODW 3ODX 3P6A	2KWF
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Blood Coagulation Hemostasis Positive Regulation Of Intracellular Signal Transduction Ras Protein Signal Transduction Response To Stress Regulation Of Body Fluid Levels Wound Healing Positive Regulation Of ERK1 And ERK2 Cascade Response To Wounding Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of ERK1 And ERK2 Cascade Platelet Activation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Rho Protein Signal Transduction Signal Transduction Cell Cycle Process Tissue Development Regulation Of Intracellular Signal Transduction Epithelium Development Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signal Transduction Small GTPase Mediated Signal Transduction Signaling Cell Communication Positive Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Stimulus Regulation Of Signaling Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Cycle Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Peptidyl-serine Phosphorylation Anatomical Structure Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Energy Reserve Metabolic Process Tube Morphogenesis Response To Organic Substance Positive Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Regulation Of Cell Morphogenesis Morphogenesis Of An Epithelium Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus	Gene Expression Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Heterocycle Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Cell Cycle Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of DNA Binding Negative Regulation Of Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Multicellular Organismal Development Negative Regulation Of Cellular Protein Metabolic Process Organ Development Regulation Of Metabolic Process Regulation Of Binding System Development Regulation Of Nitrogen Compound Metabolic Process Developmental Process Regulation Of Gene Expression Central Nervous System Development Anatomical Structure Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Negative Regulation Of DNA Binding Positive Regulation Of Cellular Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Macromolecule Biosynthetic Process Cell Fate Commitment Enzyme Linked Receptor Protein Signaling Pathway
Tagcloud ?		activates angiotensin arterial arteries causative elusive environmental exchange feature frequent guanine hypertension ii inactivation industrialized monomeric muscle pathologies phosphorylates recognized remains responsible rhoa smooth specifically tyr738 unclear undescribed world	action activities agent beta biejiajian catenin cultured cyclin cytoplasmic d1 downstream expressions fed hepatocellular hepg2 immunofluorescence inhibiting invasiveness lowered luciferase mmp pills qrt sera serve suppress underlying whose wnt
Tagcloud (Difference) ?		activates angiotensin arterial arteries causative elusive environmental exchange feature frequent guanine hypertension ii inactivation industrialized monomeric muscle pathologies phosphorylates recognized remains responsible rhoa smooth specifically tyr738 unclear undescribed world	action activities agent beta biejiajian catenin cultured cyclin cytoplasmic d1 downstream expressions fed hepatocellular hepg2 immunofluorescence inhibiting invasiveness lowered luciferase mmp pills qrt sera serve suppress underlying whose wnt
Tagcloud (Intersection) ?