ARHGEF1 and CNKSR1

Number of citations of the paper that reports this interaction (PMID 15753034)
17

Data Source:
HPRD (in vivo)

		ARHGEF1	CNKSR1
Gene Name		Rho guanine nucleotide exchange factor (GEF) 1	connector enhancer of kinase suppressor of Ras 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Plasma Membrane Cell-cell Junction Cell Cortex
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Poly(A) RNA Binding	Protein Binding, Bridging
	Biological Process	Rho Protein Signal Transduction Cell Proliferation Positive Regulation Of Rho GTPase Activity Termination Of G-protein Coupled Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Axonogenesis Negative Regulation Of Axonogenesis	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Rho Protein Signal Transduction
Pathways		Signaling by GPCR GPCR downstream signaling Signalling by NGF Axonal growth inhibition (RHOA activation) p75NTR regulates axonogenesis G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: ATR CD44 CNKSR1 CSNK1E GNA13 HRAS PRKCA RAP1A RHOA SREBF2 TCF4	18 interactors: ARHGEF1 BRAP CADM4 CYTH3 CYTH4 MAP2K2 MAP2K7 MAP3K10 PIN1 RAF1 RALGDS RASSF1 RHOA RHPN1 SMAD4 STK3 STK4 ZDHHC17
Entrez ID		9138	10256
HPRD ID		03511	11937
Ensembl ID		ENSG00000076928	ENSG00000142675
Uniprot IDs		Q6NX52 Q92888	Q53GM7 Q969H4
PDB IDs		1IAP 1SHZ 3AB3 3ODO 3ODW 3ODX 3P6A	1WWV
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Blood Coagulation Hemostasis Positive Regulation Of Intracellular Signal Transduction Ras Protein Signal Transduction Response To Stress Regulation Of Body Fluid Levels Wound Healing Positive Regulation Of ERK1 And ERK2 Cascade Response To Wounding Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of ERK1 And ERK2 Cascade Platelet Activation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Rho Protein Signal Transduction Signal Transduction Cell Cycle Process Tissue Development Regulation Of Intracellular Signal Transduction Epithelium Development Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signal Transduction Small GTPase Mediated Signal Transduction Signaling Cell Communication Positive Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Stimulus Regulation Of Signaling Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Cycle Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Peptidyl-serine Phosphorylation Anatomical Structure Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Energy Reserve Metabolic Process Tube Morphogenesis Response To Organic Substance Positive Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Regulation Of Cell Morphogenesis Morphogenesis Of An Epithelium Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus	Regulation Of Signal Transduction Regulation Of Signaling Ras Protein Signal Transduction Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Signal Transduction By Phosphorylation Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Modification Process Regulation Of Catalytic Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Positive Regulation Of Signal Transduction Signaling Endocardium Development Small GTPase Mediated Signal Transduction Cell Communication Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Phosphorylation Neurotrophin Signaling Pathway MAPK Cascade Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Protein Metabolic Process Regulation Of Stress-activated MAPK Cascade Regulation Of Protein Kinase Activity Activation Of MAPKK Activity Positive Regulation Of MAPK Cascade Regulation Of Kinase Activity Protein Autophosphorylation Primitive Hemopoiesis Response To Stimulus Cellular Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		activates angiotensin arterial arteries causative elusive environmental exchange feature frequent guanine hypertension ii inactivation industrialized monomeric muscle pathologies phosphorylates recognized remains responsible rhoa smooth specifically tyr738 unclear undescribed world
Tagcloud (Difference) ?		activates angiotensin arterial arteries causative elusive environmental exchange feature frequent guanine hypertension ii inactivation industrialized monomeric muscle pathologies phosphorylates recognized remains responsible rhoa smooth specifically tyr738 unclear undescribed world
Tagcloud (Intersection) ?