F2RL3 and F2RL2

Number of citations of the paper that reports this interaction (PMID 10766244)
79

Data Source:
HPRD (in vivo)

		F2RL3	F2RL2
Gene Name		coagulation factor II (thrombin) receptor-like 3	coagulation factor II (thrombin) receptor-like 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane
	Molecular Function	Thrombin Receptor Activity	Phosphatidylinositol Phospholipase C Activity Protein Binding Thrombin Receptor Activity
	Biological Process	Signal Transduction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Blood Coagulation Response To Wounding Platelet Activation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Platelet Dense Granule Organization Thrombin Receptor Signaling Pathway	Blood Coagulation Metabolic Process Response To Wounding Platelet Activation Thrombin Receptor Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs) GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Platelet activation, signaling and aggregation	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs) GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: F2 F2RL2	8 interactors: CDH5 CTSG ECT2 F11R F2 F2RL3 JAM2 JAM3
Entrez ID		9002	2151
HPRD ID		04148	03561
Ensembl ID			ENSG00000164220
Uniprot IDs		Q96RI0	O00254
PDB IDs		2ZPK 3QDZ
Enriched GO Terms of Interacting Partners?		Platelet Activation Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Negative Regulation Of Fibrinolysis Cell Activation Response To Wounding Thrombin Receptor Signaling Pathway Peptidyl-glutamic Acid Carboxylation Regulation Of Fibrinolysis Blood Coagulation, Intrinsic Pathway Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Platelet Activation Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Metabolic Process Regulation Of Astrocyte Differentiation Fibrinolysis Regulation Of Platelet Activation Positive Regulation Of Blood Coagulation Negative Regulation Of Glial Cell Differentiation Regulation Of Collagen Metabolic Process Positive Regulation Of Calcium Ion Transport Into Cytosol Acute-phase Response Positive Regulation Of Coagulation Positive Regulation Of Wound Healing Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Wound Healing Acute Inflammatory Response Regulation Of Glial Cell Differentiation Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Calcium Ion Transport Regulation Of Blood Coagulation Regulation Of Gliogenesis Positive Regulation Of Cell Growth Regulation Of Wound Healing Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Cell Shape Regulation Of Ion Homeostasis Protein Activation Cascade Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Cytosolic Calcium Ion Homeostasis	Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Leukocyte Migration Response To Wounding Extracellular Matrix Organization Extracellular Structure Organization Response To Stress Cell Junction Assembly Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell-cell Junction Organization Positive Regulation Of Intracellular Transport Positive Regulation Of Calcium Ion Transport Into Cytosol Cell Migration Tight Junction Assembly Cell Motility Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Stimulus Apical Junction Assembly Immune System Process Inflammatory Response Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Intracellular Transport Regulation Of Actin Cytoskeleton Organization By Cell-cell Adhesion Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Cell Adhesion Positive Regulation Of Calcium Ion Transport Locomotion Regulation Of Cytoskeleton Organization Defense Response Neutrophil Mediated Killing Of Gram-positive Bacterium Cell-cell Junction Assembly Movement Of Cell Or Subcellular Component Regulation Of Ion Homeostasis Positive Regulation Of Transport Regulation Of Blood Pressure Cell Surface Receptor Signaling Pathway Regulation Of Calcium Ion Transport Platelet Activation Positive Regulation Of Ion Transport Establishment Of Endothelial Intestinal Barrier Regulation Of Cellular Component Organization Killing By Host Of Symbiont Cells Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Organelle Organization Myeloid Progenitor Cell Differentiation Signaling Platelet Dense Granule Organization Blood Vessel Maturation
Tagcloud ?			al7a1 arhgap1 c25h16orf71 conceptus ddx58 degs endometria ensbtat00000050193 estrus fbxl7 herc6 ifi16 ifnt insemination lims2 loc507810 mgc127874 mgc128929 parp12 rnaseq rnf213 samd9 serbp1 srgap2 tbc1d1 wbscr17 znfx1 zswim4 zxfx1
Tagcloud (Difference) ?			al7a1 arhgap1 c25h16orf71 conceptus ddx58 degs endometria ensbtat00000050193 estrus fbxl7 herc6 ifi16 ifnt insemination lims2 loc507810 mgc127874 mgc128929 parp12 rnaseq rnf213 samd9 serbp1 srgap2 tbc1d1 wbscr17 znfx1 zswim4 zxfx1
Tagcloud (Intersection) ?