CLOCK

Gene Name		clock circadian regulator
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Chromosome Cytosol Chromatoid Body Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Core Promoter Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Histone Acetyltransferase Activity Signal Transducer Activity Protein Binding Chromatin DNA Binding Sequence-specific DNA Binding Protein Dimerization Activity E-box Binding
	Biological Process	DNA Damage Checkpoint Chromatin Organization Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Signal Transduction Spermatogenesis Circadian Rhythm Photoperiodism Histone Acetylation Circadian Regulation Of Gene Expression Regulation Of Hair Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Inflammatory Response Regulation Of Insulin Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Redox State Cellular Response To Ionizing Radiation Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glucocorticoid Receptor Signaling Pathway
Pathways		PPARA activates gene expression Chromatin modifying enzymes Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Chromatin organization Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) REV-ERBA represses gene expression HATs acetylate histones BMAL1:CLOCK,NPAS2 activates circadian gene expression RORA activates circadian gene expression
Drugs
Diseases
GWAS		Personality dimensions ( 18957941)
Protein-protein Interactions		7 interactors: ARNTL ARNTL2 EP300 KAT2B PER3 RARA RXRA
Entrez ID		9575
HPRD ID		03508
Ensembl ID		ENSG00000134852
Uniprot IDs		O15516 Q3ZCT4 Q53EU0
PDB IDs		4H10
Enriched GO Terms of Interacting Partners?		Rhythmic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Circadian Rhythm Transcription, DNA-templated RNA Biosynthetic Process N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Circadian Rhythm Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated N-terminal Protein Amino Acid Acetylation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Circadian Rhythm Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Retinoic Acid Receptor Signaling Pathway N-terminal Protein Amino Acid Modification Signal Transduction Ventricular Cardiac Muscle Cell Differentiation DNA-templated Transcription, Initiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Cell Communication Positive Regulation Of Metabolic Process Regulation Of Cell Cycle
Tagcloud ?		albuginea bothersome bump bumps corporal corpus correcting curvature disadvantages dorsum entails erection impotence intercourse neurovascular nonabsorbable palpable penis phenylephrine plication plications priapism recurred requested spongiosum straighter straightness sutures thickest tunica