NAPA and NSF

Number of citations of the paper that reports this interaction (PMID 9362506)
41

Data Source:
HPRD (in vivo)

		NAPA	NSF
Gene Name		N-ethylmaleimide-sensitive factor attachment protein, alpha	N-ethylmaleimide-sensitive factor
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Vacuolar Membrane Cytosol Membrane SNARE Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Extracellular Vesicular Exosome	Cytoplasm Lysosomal Membrane Golgi Stack Cytosol Plasma Membrane Postsynaptic Density Dendritic Shaft Extracellular Vesicular Exosome
	Molecular Function	Soluble NSF Attachment Protein Activity Protein Binding Syntaxin Binding	Protein Binding ATP Binding ATPase Activity Syntaxin-1 Binding Rab GTPase Binding Protein Kinase Binding PDZ Domain Binding Protein Complex Binding ATPase Activity, Coupled Metal Ion Binding
	Biological Process	Intracellular Protein Transport Intra-Golgi Vesicle-mediated Transport Post-Golgi Vesicle-mediated Transport Brain Development Regulation Of Synaptic Vesicle Priming Neuron Differentiation Synaptic Transmission, Glutamatergic SNARE Complex Disassembly Apical Protein Localization Membrane Organization Membrane Fusion	Positive Regulation Of Receptor Recycling Potassium Ion Transport Exocytosis Intra-Golgi Vesicle-mediated Transport Synaptic Transmission Vesicle-mediated Transport Regulation Of Exocytosis Golgi To Plasma Membrane Protein Transport Plasma Membrane Fusion Golgi Vesicle Docking
Pathways		Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding	Trafficking of GluR2-containing AMPA receptors Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Parkinson's disease ( 19915575 21812969)
Protein-Protein Interactions		17 interactors: APP BNIP1 GNA12 GOSR1 GOSR2 NSF RTN4 SNAP23 SNAP25 STX12 STX1A STX4 STX5 STX7 STX8 TRPC3 VAMP8	25 interactors: ARRB1 C14orf1 CD28 DRD2 EIF3E FUNDC2 GABARAP GABARAPL2 GABBR1 GABBR2 GOSR1 GRIA2 GRIA3 KIAA1377 LUC7L2 NAPA NAPG PTPN9 RAMP3 RPLP1 STX1A STX4 STX8 USO1 VAPA
Entrez ID		8775	4905
HPRD ID		04447	03380
Ensembl ID		ENSG00000105402	ENSG00000073969
Uniprot IDs		P54920	P46459
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Fusion Organelle Fusion Vesicle Fusion Vesicle Organization Membrane Organization Vesicle-mediated Transport Vesicle Docking Membrane Docking Establishment Of Localization In Cell Intracellular Transport Synaptic Vesicle Fusion To Presynaptic Membrane Cellular Localization Protein Transport Golgi Vesicle Transport Establishment Of Protein Localization Exocytosis Post-Golgi Vesicle-mediated Transport Transport Protein Localization Secretion By Cell Regulation Of Protein Localization To Plasma Membrane Synaptic Vesicle Exocytosis Intracellular Protein Transport Organelle Organization Secretion Regulation Of Cellular Localization Neurotransmitter Secretion Synaptic Vesicle Transport Cellular Protein Localization Regulation Of Cellular Component Organization Regulation Of Neurotransmitter Levels Regulation Of Exocytosis Neurotransmitter Transport Intra-Golgi Vesicle-mediated Transport Organelle Localization Platelet Activation Positive Regulation Of Exocytosis Establishment Of Vesicle Localization Regulation Of Protein Localization Endosomal Transport Vesicle Localization Retrograde Transport, Endosome To Golgi Synaptic Vesicle Docking Vesicle Fusion With Golgi Apparatus SNARE Complex Assembly Synaptic Vesicle Priming Regulation Of Hormone Secretion Regulation Of Body Fluid Levels ER To Golgi Vesicle-mediated Transport Synaptic Transmission	Membrane Fusion Membrane Organization Intracellular Transport Golgi Vesicle Transport Protein Localization Establishment Of Localization In Cell Protein Transport Synaptic Transmission Vesicle-mediated Transport Establishment Of Protein Localization Cellular Localization Cell-cell Signaling Intracellular Protein Transport Vesicle Fusion Intra-Golgi Vesicle-mediated Transport Cellular Protein Localization Neuron-neuron Synaptic Transmission Organelle Fusion Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Vesicle Organization Negative Regulation Of CAMP Biosynthetic Process Transport Mitochondrion Degradation Negative Regulation Of CAMP Metabolic Process Negative Regulation Of Nucleotide Metabolic Process Organelle Disassembly Synaptic Transmission, Glutamatergic Receptor Internalization Regulation Of Synaptic Vesicle Priming Regulation Of Protein Localization To Plasma Membrane Regulation Of Adenylate Cyclase Activity Regulation Of Vesicle-mediated Transport Regulation Of Cyclase Activity Regulation Of Insulin Secretion Synaptic Vesicle Fusion To Presynaptic Membrane Cytoplasmic Transport Regulation Of Cellular Localization G-protein Coupled Receptor Internalization Regulation Of Peptide Hormone Secretion Cellular Component Assembly Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Receptor Metabolic Process Vesicle Docking Post-Golgi Vesicle-mediated Transport Regulation Of CAMP Biosynthetic Process Membrane Docking Regulation Of Protein Localization Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway
Tagcloud ?		account activate alter beta cat construct contains cotransfected delta demonstrating element half independence inducing neuroblastoma phenylacetate promoting ra rar rare re reporter retinoic sodium sv synergize synergy upregulating vector	acetate alkylating amount apical associate attachment bound caco cellubrevin coimmunoprecipitation colocalizes connection define docking epithelium ethylmaleimide munc myristate phorbol predominantly quantity sec1 snap snare snares syntaxin thought verified vesicles
Tagcloud (Difference) ?		account activate alter beta cat construct contains cotransfected delta demonstrating element half independence inducing neuroblastoma phenylacetate promoting ra rar rare re reporter retinoic sodium sv synergize synergy upregulating vector	acetate alkylating amount apical associate attachment bound caco cellubrevin coimmunoprecipitation colocalizes connection define docking epithelium ethylmaleimide munc myristate phorbol predominantly quantity sec1 snap snare snares syntaxin thought verified vesicles
Tagcloud (Intersection) ?