CBR3 and ARIH2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CBR3	ARIH2
Gene Name		carbonyl reductase 3	ariadne RBR E3 ubiquitin protein ligase 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleoplasm Cytoplasm Cytosol	Nucleus Cytoplasm
	Molecular Function	3-keto Sterol Reductase Activity Carbonyl Reductase (NADPH) Activity NADPH Binding	Nucleic Acid Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity
	Biological Process	Phylloquinone Catabolic Process Cognition Oxidation-reduction Process	Protein Polyubiquitination Multicellular Organismal Development Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Developmental Cell Growth Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Hematopoietic Stem Cell Proliferation
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Bone mineral density ( 22504420)
Protein-Protein Interactions		4 interactors: ARIH2 RAB35 SDCBP UBC	44 interactors: ARAP1 BUB1 CBR3 CCDC33 CUL5 DISC1 DLST EEF1A1 EEF1G EML4 ENSA IL4R KAT5 KCNQ2 KIAA1377 LOC147791 NEDD8 PHF7 PPP2R1A PTN REL RHEB RPL8 SCAMP2 SGCE SLC1A6 TP53 TRIM27 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2L6 UBE2N UBE2R2 UBE2T UBE2V1 UGP2 UTP14A WDR91
Entrez ID		874	10425
HPRD ID		07222	09286
Ensembl ID		ENSG00000159231	ENSG00000177479
Uniprot IDs		O75828	O95376 Q6IBL8
PDB IDs		2HRB
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Endosomal Transport Ras Protein Signal Transduction Positive Regulation Of Extracellular Vesicular Exosome Assembly Antigen Processing And Presentation Regulation Of Extracellular Vesicular Exosome Assembly Intracellular Transport Plasma Membrane To Endosome Transport Protein Localization To Endosome Cell Development Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Viral Protein Processing Intracellular Signal Transduction Substrate-dependent Cell Migration, Cell Extension Positive Regulation Of MAPK Cascade Establishment Of Localization In Cell Hematopoietic Stem Cell Proliferation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Immune System Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Cellular Response To Growth Factor Stimulus Response To Growth Factor Notch Receptor Processing Protein Modification By Small Protein Conjugation Protein Catabolic Process Endocytic Recycling Virion Assembly Cellular Localization Regulation Of MAPK Cascade Small GTPase Mediated Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Organelle Assembly Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Response To Nerve Growth Factor Stimulus Glycogen Biosynthetic Process Intracellular Transport Of Virus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Protein K63-linked Ubiquitination Substrate-dependent Cell Migration Protein K48-linked Ubiquitination Cellular Polysaccharide Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Neuron Projection Development Polysaccharide Biosynthetic Process Cellular Macromolecule Catabolic Process	Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein K63-linked Ubiquitination Protein K11-linked Ubiquitination Modification-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cell Cycle Process ISG15-protein Conjugation Catabolic Process Cellular Protein Metabolic Process Cellular Protein Modification Process Toll-like Receptor 4 Signaling Pathway Protein Monoubiquitination Cell Cycle Toll-like Receptor Signaling Pathway Mitotic Cell Cycle Process Pattern Recognition Receptor Signaling Pathway Mitotic Cell Cycle Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Activation Of Innate Immune Response Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein Metabolic Process Positive Regulation Of Innate Immune Response Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Stimulus Response To Stimulus Regulation Of Chromosome Organization Regulation Of Protein Ubiquitination Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Proteolysis Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Mitotic Spindle Assembly Checkpoint Regulation Of Mitotic Cell Cycle Phase Transition Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Immune Response Regulation Of Cell Cycle Phase Transition
Tagcloud ?		abcb1 abcb5 abcc5 abcg2 adriamycin anthracycline caesius cardiomyopathy cbr1 comprehensively disposition doxorubicin fuelled glycoside individualizing maximize metabolizing neo peucetius pharmacogenetics pharmacogenomics polygenic pregnane pxr rlip76 slc22a16 streptomyces tailoring var	aldo1 anxa2 cdna cerebral characterize coding cortical ddit3 egr1 endoplasmic ero1l fold gadd153 gas5 giig11 gpi1 hig1 hypoxia microarray ndr1 neuronal p4hb profiling reinforce repressed reticulum sac1p ubiquitination vdac2
Tagcloud (Difference) ?		abcb1 abcb5 abcc5 abcg2 adriamycin anthracycline caesius cardiomyopathy cbr1 comprehensively disposition doxorubicin fuelled glycoside individualizing maximize metabolizing neo peucetius pharmacogenetics pharmacogenomics polygenic pregnane pxr rlip76 slc22a16 streptomyces tailoring var	aldo1 anxa2 cdna cerebral characterize coding cortical ddit3 egr1 endoplasmic ero1l fold gadd153 gas5 giig11 gpi1 hig1 hypoxia microarray ndr1 neuronal p4hb profiling reinforce repressed reticulum sac1p ubiquitination vdac2
Tagcloud (Intersection) ?