STX16 and PTPN12

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (two hybrid)

		STX16	PTPN12
Gene Name		syntaxin 16	protein tyrosine phosphatase, non-receptor type 12
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleolus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Cytosol Focal Adhesion Endomembrane System Membrane Integral Component Of Membrane SNARE Complex Golgi Cisterna Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Podosome Cytoplasm Cytosol Plasma Membrane Cell Junction Cell Projection
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Syntaxin Binding	Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding SH3 Domain Binding
	Biological Process	Intracellular Protein Transport Intra-Golgi Vesicle-mediated Transport Vesicle Fusion Retrograde Transport, Endosome To Golgi Vesicle Docking Golgi Ribbon Formation	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation
Pathways
Drugs
Diseases
GWAS		Cardiovascular disease risk factors ( 20838585)
Protein-Protein Interactions		10 interactors: MEOX2 NAPB PTPN12 STX4 STX6 VAMP3 VAMP4 VAMP5 VPS45 VTI1A	37 interactors: ABL1 APP BAG6 BCAR1 CGA CSH1 CSH2 CSK EFS EGFR FLT3 GRB2 IFT20 INSR JAK2 LPXN MYCBP2 NEDD9 PRKACA PRKCA PSG9 PSTPIP1 PSTPIP2 PTK2 PTK2B PXN RBM19 SHC1 SMAD5 SORBS2 STX16 TEX10 TGFB1I1 THAP2 UTRN WAS ZFP2
Entrez ID		8675	5782
HPRD ID		04718	02513
Ensembl ID		ENSG00000124222	ENSG00000127947
Uniprot IDs		B4DJX9 O14662	A4D1C5 B4E105 E9PBR5 Q05209
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Fusion Vesicle Fusion Organelle Fusion Vesicle Organization Golgi Ribbon Formation SNARE Complex Assembly Vesicle-mediated Transport Membrane Organization Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Golgi Vesicle Transport Establishment Of Localization In Cell Exocytosis Cellular Protein Localization Protein Transport Establishment Of Protein Localization Cellular Localization Intracellular Transport Endomembrane System Organization Secretion By Cell Protein Localization Retrograde Transport, Endosome To Golgi Secretion Golgi Organization Vesicle Docking Membrane Docking Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Golgi To Plasma Membrane Protein Transport Neurotransmitter Transport Endosomal Transport Golgi To Plasma Membrane Transport Transport Regulation Of Establishment Of Protein Localization To Plasma Membrane Regulation Of Protein Localization To Plasma Membrane Vesicle Docking Involved In Exocytosis Cellular Protein Complex Assembly Establishment Of Protein Localization To Plasma Membrane Organelle Organization Positive Regulation Of Eosinophil Degranulation Skeletal Muscle Tissue Development Voluntary Musculoskeletal Movement Skeletal Muscle Organ Development Protein Localization To Plasma Membrane Cellular Macromolecular Complex Assembly SNARE Complex Disassembly Somite Specification Cytoplasmic Transport Positive Regulation Of Protein Localization To Cell Surface Golgi To Vacuole Transport	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Adhesion Protein Autophosphorylation Cellular Response To Organonitrogen Compound Peptidyl-tyrosine Phosphorylation Movement Of Cell Or Subcellular Component Response To Organonitrogen Compound Cell Activation Regulation Of Protein Kinase Activity Blood Coagulation Peptidyl-tyrosine Autophosphorylation Hemostasis Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Peptide Hormone Stimulus Cellular Response To Hormone Stimulus Positive Regulation Of MAPK Cascade Cellular Response To Peptide Signal Transduction Regulation Of Kinase Activity Regulation Of MAPK Cascade Innate Immune Response Cell Surface Receptor Signaling Pathway Signaling Positive Regulation Of Protein Phosphorylation Cell Communication Regulation Of MAP Kinase Activity Peptidyl-amino Acid Modification Response To Hormone Cellular Response To Growth Factor Stimulus Platelet Activation Regulation Of Body Fluid Levels Response To Growth Factor Wound Healing Locomotion Response To Peptide Hormone Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cell Migration Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Kinase Activity Protein Phosphorylation Immune System Process Regulation Of Immune System Process Regulation Of Phosphorylation Response To Peptide
Tagcloud ?		attachment cog cog4 cog8 defining ethylmalemide golgi gs27 initiate intermediates machinery namely oligomeric platforms redirection relocalization retrograde reveals snap29 snares sorting stx5 stx6 tethering tethers uncover vesicles vesicular vicinity	cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol inpp5d mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange pxd000984 reorganization ripk1 silac threonine tnfrsf
Tagcloud (Difference) ?		attachment cog cog4 cog8 defining ethylmalemide golgi gs27 initiate intermediates machinery namely oligomeric platforms redirection relocalization retrograde reveals snap29 snares sorting stx5 stx6 tethering tethers uncover vesicles vesicular vicinity	cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol inpp5d mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange pxd000984 reorganization ripk1 silac threonine tnfrsf
Tagcloud (Intersection) ?