AOC3 and PRRG4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		AOC3	PRRG4
Gene Name		amine oxidase, copper containing 3	proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Microvillus Cell Surface Integral Component Of Membrane	Extracellular Region Integral Component Of Membrane
	Molecular Function	Cation Channel Activity Copper Ion Binding Calcium Ion Binding Protein Binding Primary Amine Oxidase Activity Protein Homodimerization Activity Protein Heterodimerization Activity Quinone Binding Tryptamine:oxygen Oxidoreductase (deaminating) Activity Aminoacetone:oxygen Oxidoreductase(deaminating) Activity Aliphatic-amine Oxidase Activity Phenethylamine:oxygen Oxidoreductase (deaminating) Activity	Molecular_function Calcium Ion Binding
	Biological Process	Cation Transport Inflammatory Response Cell Adhesion Amine Metabolic Process Response To Antibiotic Oxidation-reduction Process Cation Transmembrane Transport	Biological_process
Pathways
Drugs		Phenelzine Hydralazine 6-hydroxydopa quinone
Diseases
GWAS			Parkinson's disease (age of onset) ( 19772629)
Protein-Protein Interactions		2 interactors: PRRG4 VAV1	7 interactors: AOC3 BCL10 HDAC1 HLA-C RBBP8 UBE2K VEGFA
Entrez ID		8639	79056
HPRD ID		04770	15187
Ensembl ID		ENSG00000131471	ENSG00000135378
Uniprot IDs		K7ESB3 L0L8N9 Q16853 Q9UEU7	Q9BZD6
PDB IDs		1PU4 1US1 2C10 2C11 2Y73 2Y74 3ALA
Enriched GO Terms of Interacting Partners?			Response To Stress Embryo Development Positive Regulation Of Protein Kinase D Signaling Basophil Chemotaxis Positive Regulation Of Mast Cell Cytokine Production Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Retinal Ganglion Cell Axon Guidance Coronary Vein Morphogenesis Primitive Erythrocyte Differentiation VEGF-activated Neuropilin Signaling Pathway Lymphotoxin A Biosynthetic Process Interleukin-6 Biosynthetic Process Response To Stimulus Regulation Of Proteolysis Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Histone Deacetylase Activity Tube Formation Negative Regulation Of Transcription From RNA Polymerase II Promoter Chordate Embryonic Development Positive Regulation Of Lymphangiogenesis Cardiac Vascular Smooth Muscle Cell Development Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Positive Regulation Of Mast Cell Chemotaxis Negative Regulation Of Mature B Cell Apoptotic Process Regulation Of Retinal Ganglion Cell Axon Guidance Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Histone Deacetylase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Immune System Process Interleukin-6 Production Positive Regulation Of Deacetylase Activity Coronary Artery Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Cardiac Vascular Smooth Muscle Cell Differentiation Apoptotic Process Negative Regulation Of Cell Death Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Axon Extension Involved In Axon Guidance Cardiac Muscle Fiber Development Programmed Cell Death
Tagcloud ?		adipocytes amine aoc1 aoc2 aos benzylamine diamine glycerol histamine histaminergic ileum invalidation ko lipolysis lipolytic mao maoa maob oxidases oxidation oxidized peroxide reaching rodent semicarbazide ssao visceral
Tagcloud (Difference) ?		adipocytes amine aoc1 aoc2 aos benzylamine diamine glycerol histamine histaminergic ileum invalidation ko lipolysis lipolytic mao maoa maob oxidases oxidation oxidized peroxide reaching rodent semicarbazide ssao visceral
Tagcloud (Intersection) ?