LRRCC1 and CAPNS1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		LRRCC1	CAPNS1
Gene Name		leucine rich repeat and coiled-coil centrosomal protein 1	calpain, small subunit 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Centriole	Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Vesicular Exosome
	Molecular Function		Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Mitotic Nuclear Division Cell Division	Proteolysis Positive Regulation Of Cell Proliferation Extracellular Matrix Disassembly Extracellular Matrix Organization
Pathways			Degradation of the extracellular matrix
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: C14orf119 CAPNS1 FADD	18 interactors: AGTRAP ARHGEF6 ARR3 ATP5J2 CAPN1 CAPN2 CAST CDK4 DRG1 GET4 GNB2 IL2RG LRRCC1 PPARGC1A RAB1A STAT3 TERF1 TRAF5
Entrez ID		85444	826
HPRD ID		11160	00240
Ensembl ID		ENSG00000133739	ENSG00000126247
Uniprot IDs		B4DTJ0 Q9C099	P04632
PDB IDs			1KFU 1KFX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Motor Neuron Apoptotic Process Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Cellular Extravasation Necroptotic Signaling Pathway Positive Regulation Of Macrophage Differentiation Negative Regulation Of Activation-induced Cell Death Of T Cells Positive Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Activation-induced Cell Death Of T Cells Negative Regulation Of Necroptotic Process Positive Regulation Of Cell Proliferation Lymph Node Development Negative Regulation Of Necrotic Cell Death Regulation Of Necroptotic Process Positive Regulation Of T Cell Migration Regulation Of T Cell Migration Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Activated T Cell Proliferation Regulation Of Necrotic Cell Death Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Regulation Of Lymphocyte Migration Positive Regulation Of Interleukin-8 Production Necroptotic Process Regulation Of Activated T Cell Proliferation T Cell Homeostasis Regulation Of Type I Interferon-mediated Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Spleen Development Regulation Of T Cell Apoptotic Process Programmed Necrotic Cell Death Necrotic Cell Death Regulation Of Cell Proliferation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Interferon-gamma Production Negative Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Tumor Necrosis Factor Production Neuron Apoptotic Process Thymus Development TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Lymphocyte Apoptotic Process Neuron Death MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway T Cell Differentiation In Thymus	Negative Regulation Of Glycolytic Process Signal Transduction Response To Hypoxia Regulation Of Cell Death Cellular Response To Stimulus Signaling Cell Communication Temperature Homeostasis Regulation Of Glycolytic Process Response To Stimulus Regulation Of Apoptotic Process Response To Drug Positive Regulation Of Cell Cycle Process Cellular Response To Nitrite Response To Abiotic Stimulus Positive Regulation Of Cell Cycle Energy Derivation By Oxidation Of Organic Compounds Regulation Of Generation Of Precursor Metabolites And Energy Response To Organic Substance Interleukin-8 Secretion Cargo Loading Into COPII-coated Vesicle Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Interleukin-7-mediated Signaling Pathway Positive Regulation Of ATP Biosynthetic Process Positive Regulation Of Mitochondrial DNA Metabolic Process Cellular Response To Organic Substance Response To Stress Mitotic Cell Cycle Positive Regulation Of Energy Homeostasis Response To Statin Telomeric Loop Formation Age-dependent Telomere Shortening Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Positive Regulation Of Cell Proliferation Response To Organonitrogen Compound Interleukin-8 Production Telomere Maintenance Via Telomere Shortening Interleukin-2-mediated Signaling Pathway Positive Regulation Of Cellular Respiration Cellular Response To Oxygen Levels Respiratory Electron Transport Chain Response To Amino Acid Generation Of Precursor Metabolites And Energy Positive Regulation Of Mitotic Cell Cycle Regulation Of Cellular Process Cell Division Regulation Of Cell Proliferation Regulation Of Protein Metabolic Process Endomembrane System Organization
Tagcloud ?			afp buffalo cadaveric calpain cd34 curing facilitates fetoprotein greatest hcc hepatectomy hepatoma implantation invasiveness largest lungs microscopic microvessel modalities occult partial project regeneration remnant resection resections sizes transplantation vegfr2
Tagcloud (Difference) ?			afp buffalo cadaveric calpain cd34 curing facilitates fetoprotein greatest hcc hepatectomy hepatoma implantation invasiveness largest lungs microscopic microvessel modalities occult partial project regeneration remnant resection resections sizes transplantation vegfr2
Tagcloud (Intersection) ?