PKP4 and PGAM1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		PKP4	PGAM1
Gene Name		plakophilin 4	phosphoglycerate mutase 1 (brain)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Pole Cytoplasm Cytoskeleton Plasma Membrane Cell-cell Junction Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Desmosome Midbody Cell-cell Contact Zone Perinuclear Region Of Cytoplasm Spindle Midzone Mitotic Spindle	Cytoplasm Cytosol Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Bisphosphoglycerate Mutase Activity Bisphosphoglycerate 2-phosphatase Activity Phosphoglycerate Mutase Activity Protein Binding Protein Kinase Binding
	Biological Process	Cell-cell Junction Assembly Cell-cell Signaling Single Organismal Cell-cell Adhesion Regulation Of Cell Adhesion Positive Regulation Of Rho GTPase Activity Positive Regulation Of Cytokinesis	Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Glycolytic Process Regulation Of Glycolytic Process Pathogenesis Dephosphorylation Regulation Of Pentose-phosphate Shunt Small Molecule Metabolic Process Respiratory Burst
Pathways			Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Glycolysis Metabolism of carbohydrates
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		18 interactors: ATPAF2 CDH1 CDH2 CDH5 DSC3 DSP ERBB2IP GABARAP GOLGA2 LNX1 LZTS2 MINK1 OSGEP PAXIP1 PDZD2 PGAM1 PSEN1 TRIM23	5 interactors: ARL4D DCTN1 PCNA PKP4 XRCC6
Entrez ID		8502	5223
HPRD ID		05043	01392
Ensembl ID		ENSG00000144283	ENSG00000171314
Uniprot IDs		Q99569	P18669 Q6FHU2
PDB IDs			1LJD 1YFK 1YJX 4GPI 4GPZ
Enriched GO Terms of Interacting Partners?		Cell Adhesion Adherens Junction Organization Single Organismal Cell-cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Bundle Of His Cell To Purkinje Myocyte Communication Cell-cell Junction Organization Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Cellular Component Assembly Ventricular Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Cellular Response To Starvation Negative Regulation Of Canonical Wnt Signaling Pathway Cardiac Muscle Cell Action Potential Involved In Contraction Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cellular Response To Nutrient Levels Response To Starvation Cardiovascular System Development Cardiac Muscle Cell Action Potential Negative Regulation Of Wnt Signaling Pathway Autophagic Vacuole Assembly Cell Junction Assembly Regulation Of Protein Ubiquitination Intermediate Filament Cytoskeleton Organization Blood Vessel Development Intermediate Filament-based Process Cellular Response To Extracellular Stimulus Regulation Of Cardiac Muscle Cell Contraction Vasculature Development Cardiac Conduction Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Stress Macroautophagy Cajal-Retzius Cell Differentiation Positive Regulation Of Histone H3-K36 Methylation Regulation Of Pentose-phosphate Shunt Beta-amyloid Formation Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Membrane Potential Organelle Organization Cytoskeleton Organization Regulation Of Wnt Signaling Pathway Execution Phase Of Apoptosis Regulation Of Heart Rate Regulation Of Cellular Component Movement Regulation Of Cardiac Muscle Contraction Threonylcarbamoyladenosine Biosynthetic Process Basal Protein Localization	Positive Regulation Of Nuclease Activity Telomere Maintenance Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation Cellular Hyperosmotic Salinity Response Positive Regulation Of Hydrolase Activity DNA Recombination Cellular Response To X-ray Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Establishment Of Integrated Proviral Latency Establishment Of Viral Latency Cellular Hyperosmotic Response Hyperosmotic Salinity Response Positive Regulation Of Metabolic Process Translesion Synthesis Cellular Response To Stress Cellular Response To Salt Stress Positive Regulation Of Catalytic Activity DNA Ligation Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Postreplication Repair Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Hyperosmotic Response Nuclear DNA Replication Telomere Maintenance Via Recombination DNA Repair V(D)J Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Cellular Response To Osmotic Stress DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Melanosome Transport Response To X-ray Pigment Granule Transport Establishment Of Melanosome Localization Mitotic Cell Cycle Process Positive Regulation Of Cytokinesis Melanosome Localization Response To Salt Stress Transcription-coupled Nucleotide-excision Repair Regulation Of Catalytic Activity Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cellular Response To DNA Damage Stimulus Regulation Of Cytokinesis
Tagcloud ?			acly anabolism bioenergetic bioenergetics chemoresistance clarified clearer complexified concepts dialog dysfunctional facets flexibility glutamine hk2 ldha likewise microenvironmental modulators mycn oncometabolites owing progressed proof remodel stroma symbiosis translated warburg
Tagcloud (Difference) ?			acly anabolism bioenergetic bioenergetics chemoresistance clarified clearer complexified concepts dialog dysfunctional facets flexibility glutamine hk2 ldha likewise microenvironmental modulators mycn oncometabolites owing progressed proof remodel stroma symbiosis translated warburg
Tagcloud (Intersection) ?