PTPN5 and VTI1B

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PTPN5	VTI1B
Gene Name		protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)	vesicle transport through interaction with t-SNAREs 1B
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Synaptic Vesicle ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane SNARE Complex Late Endosome Membrane Vesicle Neuronal Cell Body Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Phosphotyrosine Binding Protein Tyrosine Phosphatase Activity	SNARE Binding SNAP Receptor Activity Chloride Channel Inhibitor Activity
	Biological Process	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation	Autophagic Vacuole Fusion Protein Targeting To Vacuole ER To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Golgi To Vacuole Transport Vesicle Docking Involved In Exocytosis Cell Proliferation Vesicle-mediated Transport Retrograde Transport, Endosome To Golgi Vesicle Fusion With Golgi Apparatus Membrane Fusion Regulation Of Protein Localization To Plasma Membrane
Pathways
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065)
Protein-Protein Interactions		11 interactors: CUL5 CXCL9 FAM58A FYN MAPK1 MAPK3 SNX4 TERF1 TMEM51 VTI1B ZBTB5	10 interactors: GOLGB1 KRTAP10-7 LDLRAD1 PTPN5 STX4 STX7 STX8 SYNE4 TNK2 TRIM59
Entrez ID		84867	10490
HPRD ID		01472	04440
Ensembl ID		ENSG00000110786	ENSG00000100568
Uniprot IDs		B7Z2F8 B7ZAF5 P54829 Q86TL3	Q9UEU0
PDB IDs		2BIJ 2BV5 2CJZ	2V8S
Enriched GO Terms of Interacting Partners?		Regulation Of Golgi Inheritance Caveolin-mediated Endocytosis Regulation Of Cellular Localization Regulation Of Golgi Organization Sensory Perception Of Pain Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune System Process Regulation Of Intracellular Transport Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Response To Epidermal Growth Factor Viral Process Platelet Activation Response To Fibroblast Growth Factor Regulation Of Cellular Response To Heat Regulation Of Cellular Component Organization Neurotrophin TRK Receptor Signaling Pathway Chemotaxis Lipopolysaccharide-mediated Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Signal Transduction Positive Regulation Of Immune Response Response To Growth Hormone Regulation Of Immune System Process Phagocytosis Response To Exogenous DsRNA Fc Receptor Signaling Pathway Cell Proliferation Immune Response-activating Cell Surface Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway JAK-STAT Cascade Vesicle-mediated Transport Toll-like Receptor 10 Signaling Pathway Cellular Response To Peptide Hormone Stimulus Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Response To Lipopolysaccharide Toll-like Receptor 2 Signaling Pathway	Vesicle Fusion Regulation Of Protein Localization To Plasma Membrane Organelle Fusion Membrane Fusion Vesicle Organization Vesicle Docking Positive Regulation Of Receptor Localization To Synapse Membrane Docking Positive Regulation Of Eosinophil Degranulation Vesicle-mediated Transport Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of Protein Localization Membrane Organization Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization To Cell Surface Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Intracellular Protein Transport Positive Regulation Of Immunoglobulin Secretion SNARE Complex Assembly Establishment Of Monopolar Cell Polarity Synaptic Vesicle Fusion To Presynaptic Membrane Regulation Of Cellular Localization Regulation Of Clathrin-mediated Endocytosis Regulation Of Immunoglobulin Secretion Establishment Of Epithelial Cell Polarity Regulation Of Vesicle-mediated Transport Regulation Of Protein Localization To Cell Surface Positive Regulation Of Regulated Secretory Pathway Early Endosome To Late Endosome Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Response To Hydroperoxide Organelle Localization Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Morphogenesis Of A Polarized Epithelium Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Cellular Protein Localization Positive Regulation Of Protein Localization To Plasma Membrane Protein Transport Establishment Or Maintenance Of Apical/basal Cell Polarity Endosome To Lysosome Transport Establishment Of Protein Localization Intracellular Transport Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Immunoglobulin Production Regulation Of Regulated Secretory Pathway Organelle Organization
Tagcloud ?		ad aggregated aggregates amyloid beneficial biology burden called discovery disrupts economic enriched hyperphosphorylated making millions modulating neurofibrillary neuropathology nfts plaques representing reviews step striatal substantial tangles trafficking turn worldwide	autophagic autophagolysosomal bacterium biogenesis burnetii chloramphenicol colocalization coxiella crv crvs endocytic endolysosomal facilitating favours heterotypic homotypic lysosomes nt phagolysosomal phagosomes replicative snare snares vacuole vacuoles vamp3 vamp7 vamp8 vti1a
Tagcloud (Difference) ?		ad aggregated aggregates amyloid beneficial biology burden called discovery disrupts economic enriched hyperphosphorylated making millions modulating neurofibrillary neuropathology nfts plaques representing reviews step striatal substantial tangles trafficking turn worldwide	autophagic autophagolysosomal bacterium biogenesis burnetii chloramphenicol colocalization coxiella crv crvs endocytic endolysosomal facilitating favours heterotypic homotypic lysosomes nt phagolysosomal phagosomes replicative snare snares vacuole vacuoles vamp3 vamp7 vamp8 vti1a
Tagcloud (Intersection) ?