PARD6G and PRKCI

Number of citations of the paper that reports this interaction (PMID 11260256)
30

Data Source:
HPRD (in vitro, two hybrid)

		PARD6G	PRKCI
Gene Name		par-6 family cell polarity regulator gamma	protein kinase C, iota
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Tight Junction Protein Complex	Golgi Membrane Nucleus Cytoplasm Endosome Cytosol Plasma Membrane Tight Junction Microtubule Cytoskeleton Apical Plasma Membrane Cell Leading Edge Schmidt-Lanterman Incisure Protein Complex Intercellular Bridge Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Binding ATP Binding Phospholipid Binding Protein Domain Specific Binding Metal Ion Binding
	Biological Process	Cell Cycle Cell Junction Assembly Cell-cell Junction Organization Cell Division Tight Junction Assembly	Protein Phosphorylation Protein Targeting To Membrane Cytoskeleton Organization Actin Filament Organization Positive Regulation Of Neuron Projection Development Vesicle-mediated Transport Cell Migration Cellular Response To Insulin Stimulus Cell Junction Assembly Negative Regulation Of Glial Cell Apoptotic Process Establishment Of Apical/basal Cell Polarity Intracellular Signal Transduction Eye Photoreceptor Cell Development Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell-cell Junction Organization Positive Regulation Of Glucose Import Secretion Neurotrophin TRK Receptor Signaling Pathway Golgi Vesicle Budding Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Glial Cell Proliferation Membrane Organization Response To Interleukin-1 Tight Junction Assembly Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways		Cell junction organization Cell-cell junction organization Tight junction interactions	Cell junction organization Cell-cell junction organization Signalling by NGF p75NTR recruits signalling complexes Tight junction interactions p75NTR signals via NF-kB p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: CDC42 PARD3 PRKCI PRKCZ RAC1	41 interactors: ADAP1 ANXA1 APP BAD CASP8 CDC42 CDK7 CHUK FABP4 FRS2 FRS3 GAPDH HRAS IKBKG IL1RAP IRAK1 MAP2K1 MAP2K5 MARK4 MBP NFKBIA PARD3 PARD6A PARD6B PARD6G PDPK1 PNMA1 RAB2A RAB4A RAC1 RHOQ SMG1 SQSTM1 SRC TSC22D1 TTR UBC USP20 VHL YWHAH YWHAZ
Entrez ID		84552	5584
HPRD ID		10138	02105
Ensembl ID		ENSG00000178184	ENSG00000163558
Uniprot IDs		Q9BYG4	P41743
PDB IDs			1VD2 1WMH 1ZRZ 3A8W 3A8X 3ZH8
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Cell Polarity Actin Filament-based Process Cell-cell Junction Organization Cell Migration Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Neuron Development Neuron Differentiation Cytoskeleton Organization Protein Localization To Membrane Locomotion Cellular Protein Localization Vascular Endothelial Growth Factor Receptor Signaling Pathway Establishment Of Cell Polarity Positive Regulation Of Cell-substrate Adhesion Movement Of Cell Or Subcellular Component Generation Of Neurons Neurogenesis Cellular Response To Growth Factor Stimulus Actin Cytoskeleton Organization Wound Healing Response To Growth Factor Neuron Projection Morphogenesis Cell Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Component Assembly Protein Localization Response To Wounding Regulation Of Cell-substrate Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Epithelial Cell Development Neuron Projection Development Cell Projection Morphogenesis Membrane Organization Positive Regulation Of Cell Differentiation Cell Part Morphogenesis Nervous System Development Positive Regulation Of Cell-cell Adhesion Cellular Localization Establishment Or Maintenance Of Apical/basal Cell Polarity Anatomical Structure Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Projection Organization Regulation Of T Cell Activation Regulation Of Cellular Localization Positive Regulation Of Cell Activation Regulation Of Substrate Adhesion-dependent Cell Spreading Cell Morphogenesis	Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Defense Response Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Immune Response Regulation Of Cell Death Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Apoptotic Process Immune System Process Response To Stress Response To Stimulus Intracellular Signal Transduction Signaling Cellular Response To Organic Substance Signal Transduction Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cell Communication Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Regulation Of Kinase Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Organic Substance Positive Regulation Of Programmed Cell Death Regulation Of Phosphorylation Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Cell Death Positive Regulation Of Kinase Activity MyD88-independent Toll-like Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Toll-like Receptor 3 Signaling Pathway Apoptotic Process Response To Fibroblast Growth Factor Negative Regulation Of Cell Death
Tagcloud ?			abcc4 aberrations amplification amplifications amplified array azd6244 comparative comprehensive ctsb erbb2 fgfr2 focal gastric genome knocked kras mek1 met opportunities pak1 specimens stard13 summary targeted therapeutics whole worldwide worse
Tagcloud (Difference) ?			abcc4 aberrations amplification amplifications amplified array azd6244 comparative comprehensive ctsb erbb2 fgfr2 focal gastric genome knocked kras mek1 met opportunities pak1 specimens stard13 summary targeted therapeutics whole worldwide worse
Tagcloud (Intersection) ?