PRKCI and PARD6B

Number of citations of the paper that reports this interaction (PMID 14676191)
42

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		PRKCI	PARD6B
Gene Name		protein kinase C, iota	par-6 family cell polarity regulator beta
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Endosome Cytosol Plasma Membrane Tight Junction Microtubule Cytoskeleton Apical Plasma Membrane Cell Leading Edge Schmidt-Lanterman Incisure Protein Complex Intercellular Bridge Extracellular Vesicular Exosome	Nucleus Cytoplasm Cytosol Plasma Membrane Tight Junction Cell Cortex Protein Complex Apical Part Of Cell Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Binding ATP Binding Phospholipid Binding Protein Domain Specific Binding Metal Ion Binding	Protein Binding
	Biological Process	Protein Phosphorylation Protein Targeting To Membrane Cytoskeleton Organization Actin Filament Organization Positive Regulation Of Neuron Projection Development Vesicle-mediated Transport Cell Migration Cellular Response To Insulin Stimulus Cell Junction Assembly Negative Regulation Of Glial Cell Apoptotic Process Establishment Of Apical/basal Cell Polarity Intracellular Signal Transduction Eye Photoreceptor Cell Development Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell-cell Junction Organization Positive Regulation Of Glucose Import Secretion Neurotrophin TRK Receptor Signaling Pathway Golgi Vesicle Budding Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Glial Cell Proliferation Membrane Organization Response To Interleukin-1 Tight Junction Assembly Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Endothelial Cell Apoptotic Process	Protein Complex Assembly Cell-cell Junction Assembly Cell Cycle Establishment Or Maintenance Of Cell Polarity Axonogenesis Regulation Of Cell Migration Cell Junction Assembly Cell-cell Junction Organization Cell Division Tight Junction Assembly
Pathways		Cell junction organization Cell-cell junction organization Signalling by NGF p75NTR recruits signalling complexes Tight junction interactions p75NTR signals via NF-kB p75 NTR receptor-mediated signalling	Cell junction organization Cell-cell junction organization Tight junction interactions
Drugs
Diseases
GWAS			Bipolar disorder ( 21771265)
Protein-Protein Interactions		41 interactors: ADAP1 ANXA1 APP BAD CASP8 CDC42 CDK7 CHUK FABP4 FRS2 FRS3 GAPDH HRAS IKBKG IL1RAP IRAK1 MAP2K1 MAP2K5 MARK4 MBP NFKBIA PARD3 PARD6A PARD6B PARD6G PDPK1 PNMA1 RAB2A RAB4A RAC1 RHOQ SMG1 SQSTM1 SRC TSC22D1 TTR UBC USP20 VHL YWHAH YWHAZ	22 interactors: APP CDC42 CEP76 GMCL1 GOLGA2 HTRA1 MPP5 PARD3 PARD3B PARD6A PNMA1 PRKCG PRKCI PRKCZ RAC1 RHOJ RHOQ TCP10 WDR83 YWHAB YWHAH YWHAZ
Entrez ID		5584	84612
HPRD ID		02105	18703
Ensembl ID		ENSG00000163558	ENSG00000124171
Uniprot IDs		P41743	Q9BYG5
PDB IDs		1VD2 1WMH 1ZRZ 3A8W 3A8X 3ZH8
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Defense Response Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Immune Response Regulation Of Cell Death Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Apoptotic Process Immune System Process Response To Stress Response To Stimulus Intracellular Signal Transduction Signaling Cellular Response To Organic Substance Signal Transduction Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cell Communication Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Regulation Of Kinase Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Organic Substance Positive Regulation Of Programmed Cell Death Regulation Of Phosphorylation Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Cell Death Positive Regulation Of Kinase Activity MyD88-independent Toll-like Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Toll-like Receptor 3 Signaling Pathway Apoptotic Process Response To Fibroblast Growth Factor Negative Regulation Of Cell Death	Cell-cell Junction Organization Enzyme Linked Receptor Protein Signaling Pathway Tight Junction Assembly Regulation Of Cellular Component Organization Membrane Organization Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Apical Junction Assembly Wound Healing Response To Growth Factor Platelet Activation Positive Regulation Of Cell Death Actin Filament-based Process Cellular Protein Localization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Intracellular Signal Transduction Blood Coagulation Regulation Of Cellular Localization Hemostasis Response To Wounding Cellular Component Assembly Regulation Of Apoptotic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Transport Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Regulation Of Protein Localization Cell-cell Junction Assembly Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Glucose Import Neurogenesis Positive Regulation Of Glucose Transport Regulation Of Body Fluid Levels Nervous System Development Regulation Of Organelle Organization Actin Cytoskeleton Organization Defense Response Establishment Of Golgi Localization Neuron Development Protein Localization To Membrane Cellular Localization Neuron Projection Morphogenesis Anatomical Structure Morphogenesis Establishment Or Maintenance Of Cell Polarity Protein Localization Regulation Of Glucose Import Positive Regulation Of Mitochondrion Organization
Tagcloud ?		abcc4 aberrations amplification amplifications amplified array azd6244 comparative comprehensive ctsb erbb2 fgfr2 focal gastric genome knocked kras mek1 met opportunities pak1 specimens stard13 summary targeted therapeutics whole worldwide worse	adm adriamycin arrb2 bigger cblb chip cryopreservation doubling effectors endoperoxide exocytosis exudation gliomas impulse ingestion mdr medip ontology pgp pkcalpha rh123 sgh snap47 tgfb1 vamp3 vamp4 verify vps4b wizened
Tagcloud (Difference) ?		abcc4 aberrations amplification amplifications amplified array azd6244 comparative comprehensive ctsb erbb2 fgfr2 focal gastric genome knocked kras mek1 met opportunities pak1 specimens stard13 summary targeted therapeutics whole worldwide worse	adm adriamycin arrb2 bigger cblb chip cryopreservation doubling effectors endoperoxide exocytosis exudation gliomas impulse ingestion mdr medip ontology pgp pkcalpha rh123 sgh snap47 tgfb1 vamp3 vamp4 verify vps4b wizened
Tagcloud (Intersection) ?