HIST2H2BE and USP12

Number of citations of the paper that reports this interaction (PMID 21183687)
19

Data Source:
BioGRID (enzymatic study)

		HIST2H2BE	USP12
Gene Name		histone cluster 2, H2be	ubiquitin specific peptidase 12
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Extracellular Space Nucleus Nucleoplasm Extracellular Vesicular Exosome	Cellular_component
	Molecular Function	DNA Binding Protein Heterodimerization Activity	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding
	Biological Process	Innate Immune Response In Mucosa Chromatin Organization Nucleosome Assembly Antibacterial Humoral Response Defense Response To Gram-positive Bacterium	Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Chromatin organization HDACs deacetylate histones misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS			Alcohol dependence ( 21314694) Ulcerative colitis ( 19915573)
Protein-Protein Interactions		74 interactors: AIRE AKT1 ANP32A ARID1B ATF2 ATXN7L3 BAZ1B BRD2 BRD7 CDK9 CHFR CREBBP DNMT3L DYRK2 EP300 GADD45A GATAD2A GATAD2B GZMA HDAC2 HIPK2 HIRA HIRIP3 HIST1H4A HIST2H2AC HSPD1 IL33 IL7R KAT2A KAT2B KPNA1 LALBA LOX MAP4K4 MDM2 MSL1 MSL2 MST1 NAP1L4 NCL NPM1 PARP10 PBRM1 PELP1 PRMT6 PTMA RAG1 RCC1 RNF20 RNF40 RNF8 RPS6KA5 SAP30 SART3 SIRT7 SMARCA4 SSRP1 STK4 TAF1A TAF1B TBL1X TBL1XR1 TCF20 TGM2 TNPO1 TSPY1 UBC UBE2A USP12 USP15 USP22 USP46 USP49 VRK1	5 interactors: APP HIST2H2AC HIST2H2BE NOTCH1 UBC
Entrez ID		8349	219333
HPRD ID		03494	15631
Ensembl ID		ENSG00000184678	ENSG00000152484
Uniprot IDs		Q16778	O75317
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Modification Chromosome Organization Histone Modification Organelle Organization Cellular Protein Modification Process Cellular Metabolic Process Regulation Of Gene Expression Gene Expression Positive Regulation Of Gene Expression Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Chromatin Remodeling Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Peptidyl-amino Acid Modification Cellular Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Chromatin Assembly Or Disassembly Protein Catabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Histone Acetylation Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Internal Peptidyl-lysine Acetylation Cellular Protein Catabolic Process Viral Process Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation	Notch Signaling Pathway Notch Receptor Processing Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Defense Response Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Venous Endothelial Cell Differentiation Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Cellular Response To Oxygen Levels Immune System Process Negative Regulation Of Catalytic Activity Developmental Growth Involved In Morphogenesis Innate Immune Response Negative Regulation Of Canonical Wnt Signaling Pathway Vasculogenesis Involved In Coronary Vascular Morphogenesis Synaptic Growth At Neuromuscular Junction Cardiac Right Atrium Morphogenesis Mitral Valve Formation Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Pro-B Cell Differentiation Growth Involved In Heart Morphogenesis Atrioventricular Node Development Collateral Sprouting In Absence Of Injury Coronary Vein Morphogenesis Apoptotic Process Negative Regulation Of Neuron Differentiation Negative Regulation Of Wnt Signaling Pathway Intracellular Receptor Signaling Pathway Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Cell Migration Involved In Endocardial Cushion Formation Cardiac Right Ventricle Formation Negative Regulation Of Endothelial Cell Chemotaxis Negative Regulation Of Photoreceptor Cell Differentiation Cell Death Death Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Canonical Wnt Signaling Pathway DNA-templated Transcription, Initiation Response To Abiotic Stimulus
Tagcloud ?		5p15 angiogenesis aza bdkrb2 biomarker dc encoding fgf7 gastric global heterozygosity hypermethylation immunoprecipitation invasion irx1 located locus lost microarray n87 nci partially restored restoring serve sgc susceptibility transfection tumorigenesis	androgen ar chip cofactors deubiquitinates deubiquitinating deubiquitination e3 enhancing enzymatic enzymes equally hence impacts interplay ligases mdm2 nedd4 offer prostate protease proteosomal screen stabilizing uaf ubiquitin ubiquitinated ubiquitination wdr20
Tagcloud (Difference) ?		5p15 angiogenesis aza bdkrb2 biomarker dc encoding fgf7 gastric global heterozygosity hypermethylation immunoprecipitation invasion irx1 located locus lost microarray n87 nci partially restored restoring serve sgc susceptibility transfection tumorigenesis	androgen ar chip cofactors deubiquitinates deubiquitinating deubiquitination e3 enhancing enzymatic enzymes equally hence impacts interplay ligases mdm2 nedd4 offer prostate protease proteosomal screen stabilizing uaf ubiquitin ubiquitinated ubiquitination wdr20
Tagcloud (Intersection) ?