CAST and PPFIA3

Number of citations of the paper that reports this interaction (PMID 12923177)
33

Data Source:
HPRD (in vitro, two hybrid)

		CAST	PPFIA3
Gene Name		calpastatin	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Membrane	Cytosol Cell Surface Presynaptic Active Zone
	Molecular Function	Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Poly(A) RNA Binding	Protein Binding
	Biological Process	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Type B Pancreatic Cell Apoptotic Process	Synaptic Transmission Neurotransmitter Secretion Glutamate Secretion Regulation Of Short-term Neuronal Synaptic Plasticity
Pathways			Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs		Calcium
Diseases
GWAS		Alcohol dependence ( 19581569)
Protein-Protein Interactions		10 interactors: CAPN1 CAPNS1 CASP1 CASP3 CASP7 HTRA1 PPFIA1 PPFIA2 PPFIA3 PPFIA4	12 interactors: CAST ERC2 GIT1 PPFIA1 PPFIA2 PPFIBP1 PPFIBP2 PTPRD PTPRF PTPRG PTPRS PTPRU
Entrez ID		831	8541
HPRD ID		00233	04393
Ensembl ID		ENSG00000153113	ENSG00000177380
Uniprot IDs		P20810 Q59HE3 Q86YM9	O75145
PDB IDs
Enriched GO Terms of Interacting Partners?		Glutamate Secretion Acid Secretion Dicarboxylic Acid Transport Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Amino Acid Transport Neurotransmitter Transport Execution Phase Of Apoptosis Carboxylic Acid Transport Organic Acid Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Extracellular Matrix Disassembly Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Organic Anion Transport Positive Regulation Of Peptidase Activity Secretion By Cell Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Synaptic Transmission Regulation Of Cysteine-type Endopeptidase Activity Secretion Anion Transport Protein Processing Positive Regulation Of Proteolysis Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell-cell Signaling Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Mitochondrial Depolarization Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Dentinogenesis Positive Regulation Of Cell Death Cell-matrix Adhesion Regulation Of Proteolysis Regulation Of Cell Proliferation Positive Regulation Of Interleukin-1 Alpha Production Pyroptosis Signaling Intrinsic Apoptotic Signaling Pathway Cell Communication Glial Cell Apoptotic Process	Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Peptidyl-tyrosine Dephosphorylation Protein Dephosphorylation Cell Adhesion Enzyme Linked Receptor Protein Signaling Pathway Dephosphorylation Signaling Cell Communication Glutamate Secretion Signal Transduction Acid Secretion Dicarboxylic Acid Transport Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Amino Acid Transport Neurotransmitter Transport Cell-matrix Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Negative Regulation Of Cell Migration Negative Regulation Of Receptor Binding Cell-substrate Adhesion Presynaptic Membrane Assembly Negative Regulation Of Cell Motility Phosphate-containing Compound Metabolic Process Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Cellular Component Movement Response To Stimulus Presynaptic Membrane Organization Negative Regulation Of Locomotion Negative Regulation Of Actin Filament Bundle Assembly Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Cellular Protein Modification Process Corpus Callosum Development Carboxylic Acid Transport Organic Acid Transport Protein Localization To Cell Surface Negative Regulation Of Protein Localization To Plasma Membrane Membrane Assembly RRNA Transcription Regulation Of Neuron Projection Development Nervous System Development Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Membrane Biogenesis
Tagcloud ?		absent antiserum b1 cardiomyocyte discs doubt dreifuss dystrophy edmd emerin emery explanation intercalated intranuclear lamin lamina lap1 lap2 lbr libraries localize mabs muscular myocyte nuclei phage recognize rim spots
Tagcloud (Difference) ?		absent antiserum b1 cardiomyocyte discs doubt dreifuss dystrophy edmd emerin emery explanation intercalated intranuclear lamin lamina lap1 lap2 lbr libraries localize mabs muscular myocyte nuclei phage recognize rim spots
Tagcloud (Intersection) ?