CAST and CASP1

Number of citations of the paper that reports this interaction (PMID 9705209)
28

Data Source:
HPRD (in vitro)

		CAST	CASP1
Gene Name		calpastatin	caspase 1, apoptosis-related cysteine peptidase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Membrane	Extracellular Region Cytoplasm Cytosol IPAF Inflammasome Complex NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex
	Molecular Function	Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Poly(A) RNA Binding	Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
	Biological Process	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Type B Pancreatic Cell Apoptotic Process	Response To Hypoxia Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Regulation Of Autophagy Response To Lipopolysaccharide Interleukin-1 Beta Production Response To ATP Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Inflammatory Response Mitochondrial Depolarization Membrane Hyperpolarization Pyroptosis Cellular Response To Mechanical Stimulus Cellular Response To Organic Substance Execution Phase Of Apoptosis Programmed Necrotic Cell Death Toxin Transport
Pathways			Signaling by Interleukins The NLRP3 inflammasome Inflammasomes NOD1/2 Signaling Pathway The AIM2 inflammasome Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Interleukin-1 processing The IPAF inflammasome Cytokine Signaling in Immune system Innate Immune System
Drugs		Calcium	Minocycline 1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE 3-[2-(2-BENZYLOXYCARBONYLAMINO-3-METHYL-BUTYRYLAMINO)-PROPIONYLAMINO]-4-OXO-PENTANOIC ACID 3-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACID
Diseases
GWAS		Alcohol dependence ( 19581569)
Protein-Protein Interactions		10 interactors: CAPN1 CAPNS1 CASP1 CASP3 CASP7 HTRA1 PPFIA1 PPFIA2 PPFIA3 PPFIA4	42 interactors: AR ATN1 ATXN3 BCAP31 BCL2L1 BID CARD16 CARD17 CARD8 CASP10 CASP14 CASP4 CASP8 CAST CDK11B EGFR FGF2 HTT IL18 IL1A IL1B IL33 IL37 LMNA MAPT NEDD4 NFE2L2 NLRC4 NLRP1 NOD1 PAK1 PARK2 PARP1 PLA2G4A PLA2G4B PSEN1 PSEN2 PYCARD RIPK2 TFAP2A TIRAP VAC14
Entrez ID		831	834
HPRD ID		00233	00977
Ensembl ID		ENSG00000153113	ENSG00000137752
Uniprot IDs		P20810 Q59HE3 Q86YM9	A8K249 A8K257 P29466
PDB IDs			1BMQ 1IBC 1ICE 1RWK 1RWM 1RWN 1RWO 1RWP 1RWV 1RWW 1RWX 1SC1 1SC3 1SC4 2FQQ 2H48 2H4W 2H4Y 2H51 2H54 2HBQ 2HBR 2HBY 2HBZ 3D6F 3D6H 3D6M 3E4C 3NS7
Enriched GO Terms of Interacting Partners?		Glutamate Secretion Acid Secretion Dicarboxylic Acid Transport Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Amino Acid Transport Neurotransmitter Transport Execution Phase Of Apoptosis Carboxylic Acid Transport Organic Acid Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Extracellular Matrix Disassembly Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Organic Anion Transport Positive Regulation Of Peptidase Activity Secretion By Cell Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Synaptic Transmission Regulation Of Cysteine-type Endopeptidase Activity Secretion Anion Transport Protein Processing Positive Regulation Of Proteolysis Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell-cell Signaling Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Mitochondrial Depolarization Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Dentinogenesis Positive Regulation Of Cell Death Cell-matrix Adhesion Regulation Of Proteolysis Regulation Of Cell Proliferation Positive Regulation Of Interleukin-1 Alpha Production Pyroptosis Signaling Intrinsic Apoptotic Signaling Pathway Cell Communication Glial Cell Apoptotic Process	Apoptotic Process Programmed Cell Death Regulation Of Cell Death Cell Death Death Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Response To Stress Immune Response Signaling Regulation Of Signaling Cell Communication Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Proteolysis Cellular Response To Stimulus Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Organic Substance Negative Regulation Of Cell Death Regulation Of Proteolysis Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Regulation Of Cellular Localization Cellular Response To Organic Substance Regulation Of Catalytic Activity Positive Regulation Of Apoptotic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Programmed Cell Death Immune System Process Signal Transduction Positive Regulation Of Cell Death Negative Regulation Of Programmed Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Protein Localization Regulation Of Establishment Of Protein Localization Protein Processing Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Defense Response Positive Regulation Of Cysteine-type Endopeptidase Activity
Tagcloud ?		absent antiserum b1 cardiomyocyte discs doubt dreifuss dystrophy edmd emerin emery explanation intercalated intranuclear lamin lamina lap1 lap2 lbr libraries localize mabs muscular myocyte nuclei phage recognize rim spots	10ko acp5 aia arthritic arthritis autoinflammatory blockade driven erosions ex exogenous focal hence histological histopathology il1b il33 inflammasome investigative joint neutralization nlrp3 osteoclast osteoclastogenesis pathology radiographic synovial synovium tartrate
Tagcloud (Difference) ?		absent antiserum b1 cardiomyocyte discs doubt dreifuss dystrophy edmd emerin emery explanation intercalated intranuclear lamin lamina lap1 lap2 lbr libraries localize mabs muscular myocyte nuclei phage recognize rim spots	10ko acp5 aia arthritic arthritis autoinflammatory blockade driven erosions ex exogenous focal hence histological histopathology il1b il33 inflammasome investigative joint neutralization nlrp3 osteoclast osteoclastogenesis pathology radiographic synovial synovium tartrate
Tagcloud (Intersection) ?