TCL1A and AKT2

Number of citations of the paper that reports this interaction (PMID 10983986)
50

Data Source:
HPRD (in vitro, in vivo)

		TCL1A	AKT2
Gene Name		T-cell leukemia/lymphoma 1A	v-akt murine thymoma viral oncogene homolog 2
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Cell Cortex Pronucleus	Nucleus Nucleoplasm Cytosol Plasma Membrane Cell Cortex Ruffle Membrane
	Molecular Function	Protein Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity
	Biological Process	Multicellular Organismal Development Stem Cell Maintenance	Positive Regulation Of Protein Phosphorylation Glycogen Biosynthetic Process Glucose Metabolic Process Regulation Of Translation Cellular Protein Modification Process Protein Phosphorylation Apoptotic Process Signal Transduction Insulin Receptor Signaling Pathway Carbohydrate Transport Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Positive Regulation Of Glucose Metabolic Process Regulation Of Cell Migration Positive Regulation Of Vesicle Fusion Positive Regulation Of Fatty Acid Beta-oxidation Peripheral Nervous System Myelin Maintenance Activation Of Ral GTPase Activity Cellular Response To Insulin Stimulus Fat Cell Differentiation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Mammary Gland Epithelial Cell Differentiation Membrane Organization Intracellular Protein Transmembrane Transport Regulation Of Cell Cycle Arrest Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Cell Motility Positive Regulation Of Glucose Import In Response To Insulin Stimulus
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease Activation of BH3-only proteins mTOR signalling Signaling by Wnt Activation of PKB Signaling by EGFRvIII in Cancer AKT phosphorylates targets in the cytosol Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Regulation of beta-cell development PI3K/AKT activation PI-3K cascade RNF mutants show enhanced WNT signaling and proliferation PDE3B signalling PKB-mediated events PI3K Cascade Signaling by PDGF Downregulation of ERBB2:ERBB3 signaling DAP12 interactions GAB1 signalosome misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling G-protein beta:gamma signalling CD28 co-stimulation CD28 dependent PI3K/Akt signaling PDE3B signalling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 Activation of BAD and translocation to mitochondria Signaling by EGFR GPCR downstream signaling Signaling by VEGF AKT phosphorylates targets in the nucleus Downstream signal transduction Regulation of gene expression in beta cells Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Adaptive Immune System Inhibition of TSC complex formation by PKB Activation of PKB Costimulation by the CD28 family IRS-mediated signalling PIP3 activates AKT signaling mTOR signalling Translocation of GLUT4 to the plasma membrane IGF1R signaling cascade deactivation of the beta-catenin transactivating complex VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling VEGFR2 mediated vascular permeability Downstream signaling of activated FGFR Programmed Cell Death XAV939 inhibits tankyrase, stabilizing AXIN Intrinsic Pathway for Apoptosis Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade CTLA4 inhibitory signaling AKT-mediated inactivation of FOXO1A Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events NGF signalling via TRKA from the plasma membrane Negative regulation of the PI3K/AKT network Signaling by Overexpressed Wild-Type EGFR in Cancer Inhibition of TSC complex formation by PKB Signaling by FGFR IRS-mediated signalling TCF dependent signaling in response to WNT Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) GPVI-mediated activation cascade Signaling by WNT in cancer PKB-mediated events PI3K Cascade
Drugs			N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
Diseases
GWAS		Adverse response to aromatase inhibitors ( 21172079 20876420)
Protein-Protein Interactions		21 interactors: AKT1 AKT2 AKT3 ALS2CR12 ATM CADPS CALCOCO2 CARD9 CEP55 DNMT3A GOLGA2 HIST3H2A LSM3 PRTFDC1 TCF4 TP53BP2 TRAF1 TTC33 TXLNA TXLNB WDR47	38 interactors: ABCG8 AKT1 AKT1S1 APOA1 APOB APP APPL1 CCL14 CHUK CLIP3 ESR1 FOXO4 FSHR GSK3B HIST1H3A HSP90AA1 MAP3K5 MTCP1 NAMPT PDPK1 PLEKHO1 PNPLA3 POFUT1 POLR1B PRKDC RAB3D SH3RF1 SLC2A4 SNX27 SORBS2 SPRR2A STEAP4 TCL1A TCL1B TMED2 TRIB3 TSC2 XIAP
Entrez ID		8115	208
HPRD ID		01744	01262
Ensembl ID		ENSG00000100721	ENSG00000105221
Uniprot IDs		P56279	B4DG79 P31751
PDB IDs		1JSG	1GZK 1GZN 1GZO 1MRV 1MRY 1O6K 1O6L 1P6S 2JDO 2JDR 2UW9 2X39 2XH5 3D0E 3E87 3E88 3E8D
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Glucose Metabolic Process Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Glycogen Metabolic Process Polysaccharide Metabolic Process Peripheral Nervous System Myelin Maintenance Positive Regulation Of Glycogen Biosynthetic Process Glial Cell Development Regulation Of Glucose Metabolic Process Regulation Of Fatty Acid Beta-oxidation Myelin Maintenance Mammary Gland Epithelial Cell Differentiation Energy Reserve Metabolic Process Negative Regulation Of Lipid Transport Glucose Metabolic Process Glycogen Biosynthetic Process Regulation Of Carbohydrate Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Fatty Acid Oxidation Response To Radiation Glial Cell Differentiation Regulation Of Fatty Acid Transport Cell Cycle Myelination In Peripheral Nervous System Positive Regulation Of Glucose Import Intrinsic Apoptotic Signaling Pathway Cellular Polysaccharide Biosynthetic Process Regulation Of Glycogen Metabolic Process Schwann Cell Development Positive Regulation Of Glucose Transport Regulation Of Extrinsic Apoptotic Signaling Pathway Polysaccharide Biosynthetic Process Regulation Of Cell Cycle Hexose Metabolic Process Apoptotic Process Negative Regulation Of Ion Transmembrane Transport Positive Regulation Of Intracellular Transport Cellular Carbohydrate Metabolic Process Regulation Of Myelination Gliogenesis Programmed Cell Death Schwann Cell Differentiation Monosaccharide Metabolic Process Negative Regulation Of Transmembrane Transport Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Glycogen Cell Differentiation Involved In Embryonic Placenta Development Cell Death Regulation Of Glucose Import Death Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Biosynthetic Process	Phosphatidylinositol-mediated Signaling Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Innate Immune Response Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Hormone Stimulus Response To Insulin Negative Regulation Of Catalytic Activity Cellular Response To Peptide Hormone Stimulus Immune Response-regulating Signaling Pathway Immune Response Cellular Response To Peptide Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Apoptotic Signaling Pathway Response To Hormone Insulin Receptor Signaling Pathway Immune System Process Response To Organic Substance Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Response To Peptide Hormone Defense Response Response To Abiotic Stimulus Chemical Homeostasis Negative Regulation Of Protein Phosphorylation Cellular Response To Organonitrogen Compound Signal Transduction Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Protein Metabolic Process Response To Peptide Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Apoptotic Process Cellular Response To Stimulus Negative Regulation Of Kinase Activity Regulation Of Protein Localization To Plasma Membrane Programmed Cell Death Cellular Response To Organic Substance
Tagcloud ?		14q atm coexpression cutaneous cutis epidermotropism gains immunophenotype infiltrates institution integral inversion involvement irregular karyotype lactate lymphoid manifestations papules periadnexal perivascular pll plls prolymphocytic purpura rash rearrangement sized ulcers	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Difference) ?		14q atm coexpression cutaneous cutis epidermotropism gains immunophenotype infiltrates institution integral inversion involvement irregular karyotype lactate lymphoid manifestations papules periadnexal perivascular pll plls prolymphocytic purpura rash rearrangement sized ulcers	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Intersection) ?