TCL1A and AKT3

Number of citations of the paper that reports this interaction (PMID 11707444)
15

Data Source:
HPRD (in vitro, in vivo)

		TCL1A	AKT3
Gene Name		T-cell leukemia/lymphoma 1A	v-akt murine thymoma viral oncogene homolog 3
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Cell Cortex Pronucleus	Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane
	Molecular Function	Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Multicellular Organismal Development Stem Cell Maintenance	Mitochondrial Genome Maintenance Protein Phosphorylation Signal Transduction
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease Activation of BH3-only proteins Signaling by EGFRvIII in Cancer AKT phosphorylates targets in the cytosol Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Regulation of beta-cell development PI3K/AKT activation PI-3K cascade Signaling by PDGF Downregulation of ERBB2:ERBB3 signaling DAP12 interactions GAB1 signalosome G-protein beta:gamma signalling CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 Activation of BAD and translocation to mitochondria Signaling by EGFR GPCR downstream signaling Signaling by VEGF AKT phosphorylates targets in the nucleus Downstream signal transduction Regulation of gene expression in beta cells Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Adaptive Immune System Costimulation by the CD28 family PIP3 activates AKT signaling VEGFA-VEGFR2 Pathway G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling Downstream signaling of activated FGFR VEGFR2 mediated vascular permeability Programmed Cell Death Intrinsic Pathway for Apoptosis Innate Immune System Signalling by NGF CTLA4 inhibitory signaling AKT-mediated inactivation of FOXO1A Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Negative regulation of the PI3K/AKT network Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR GPVI-mediated activation cascade
Drugs
Diseases
GWAS		Adverse response to aromatase inhibitors ( 21172079 20876420)	Diabetic retinopathy ( 21441570) Menarche (age at onset) ( 23599027) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) RR interval (heart rate) ( 20031603)
Protein-Protein Interactions		21 interactors: AKT1 AKT2 AKT3 ALS2CR12 ATM CADPS CALCOCO2 CARD9 CEP55 DNMT3A GOLGA2 HIST3H2A LSM3 PRTFDC1 TCF4 TP53BP2 TRAF1 TTC33 TXLNA TXLNB WDR47	8 interactors: GSK3B NEDD4 NEDD4L PDPK1 PRKCD PRKCZ TCL1A TSC2
Entrez ID		8115	10000
HPRD ID		01744	06441
Ensembl ID		ENSG00000100721	ENSG00000117020
Uniprot IDs		P56279	Q9Y243
PDB IDs		1JSG	2X18
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Glucose Metabolic Process Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Glycogen Metabolic Process Polysaccharide Metabolic Process Peripheral Nervous System Myelin Maintenance Positive Regulation Of Glycogen Biosynthetic Process Glial Cell Development Regulation Of Glucose Metabolic Process Regulation Of Fatty Acid Beta-oxidation Myelin Maintenance Mammary Gland Epithelial Cell Differentiation Energy Reserve Metabolic Process Negative Regulation Of Lipid Transport Glucose Metabolic Process Glycogen Biosynthetic Process Regulation Of Carbohydrate Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Fatty Acid Oxidation Response To Radiation Glial Cell Differentiation Regulation Of Fatty Acid Transport Cell Cycle Myelination In Peripheral Nervous System Positive Regulation Of Glucose Import Intrinsic Apoptotic Signaling Pathway Cellular Polysaccharide Biosynthetic Process Regulation Of Glycogen Metabolic Process Schwann Cell Development Positive Regulation Of Glucose Transport Regulation Of Extrinsic Apoptotic Signaling Pathway Polysaccharide Biosynthetic Process Regulation Of Cell Cycle Hexose Metabolic Process Apoptotic Process Negative Regulation Of Ion Transmembrane Transport Positive Regulation Of Intracellular Transport Cellular Carbohydrate Metabolic Process Regulation Of Myelination Gliogenesis Programmed Cell Death Schwann Cell Differentiation Monosaccharide Metabolic Process Negative Regulation Of Transmembrane Transport Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Glycogen Cell Differentiation Involved In Embryonic Placenta Development Cell Death Regulation Of Glucose Import Death Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Biosynthetic Process	Negative Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Negative Regulation Of Signaling Response To Growth Factor Negative Regulation Of Protein Phosphorylation Positive Regulation Of Transport Negative Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Cellular Component Organization Negative Regulation Of Insulin Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Neurotrophin Signaling Pathway Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Response To Organic Substance Positive Regulation Of Phospholipase Activity Regulation Of Protein Kinase Activity Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Transferase Activity Regulation Of Phospholipase Activity Negative Regulation Of Catalytic Activity Positive Regulation Of Lipase Activity Regulation Of Kinase Activity Regulation Of Signal Transduction Negative Regulation Of MAP Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Immune Response Negative Regulation Of Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Signaling Negative Regulation Of Cellular Response To Growth Factor Stimulus Cell Surface Receptor Signaling Pathway Negative Regulation Of Sodium Ion Transport Positive Regulation Of Hydrolase Activity Regulation Of Cellular Localization Regulation Of Protein Phosphorylation
Tagcloud ?		14q atm coexpression cutaneous cutis epidermotropism gains immunophenotype infiltrates institution integral inversion involvement irregular karyotype lactate lymphoid manifestations papules periadnexal perivascular pll plls prolymphocytic purpura rash rearrangement sized ulcers	aberrant blot candidate downregulated dysregulation effectively exact forced hcc hepatocellular invasion inversely luciferase metastasis micrornas migration mir144 mirnas numerous overexpression remains reversed suppressed suppressive suppressor targeting tissues transfected unclear
Tagcloud (Difference) ?		14q atm coexpression cutaneous cutis epidermotropism gains immunophenotype infiltrates institution integral inversion involvement irregular karyotype lactate lymphoid manifestations papules periadnexal perivascular pll plls prolymphocytic purpura rash rearrangement sized ulcers	aberrant blot candidate downregulated dysregulation effectively exact forced hcc hepatocellular invasion inversely luciferase metastasis micrornas migration mir144 mirnas numerous overexpression remains reversed suppressed suppressive suppressor targeting tissues transfected unclear
Tagcloud (Intersection) ?