FXR1 and FMR1

Number of citations of the paper that reports this interaction (PMID 8668200)
56

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		FXR1	FMR1
Gene Name		fragile X mental retardation, autosomal homolog 1	fragile X mental retardation 1
Image
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Polysome Membrane Costamere	Nucleoplasm Nucleolus Cytoplasm MRNA Cap Binding Complex Microtubule Cytoplasmic Stress Granule Membrane Cytoplasmic Ribonucleoprotein Granule Polysomal Ribosome Dendritic Spine Dendritic Shaft Cell Body Synapse Neuronal Ribonucleoprotein Granule
	Molecular Function	G-quadruplex RNA Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Poly(A) RNA Binding	RNA Binding MRNA Binding Protein Binding Microtubule Binding Poly(A) RNA Binding
	Biological Process	Apoptotic Process Muscle Organ Development Negative Regulation Of Translation Cell Differentiation	Central Nervous System Development Negative Regulation Of Translation Negative Regulation Of Translational Initiation MRNA Transport
Pathways
Drugs
Diseases
GWAS		Schizophrenia ( 19571811)	Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956)
Protein-Protein Interactions		11 interactors: C14orf1 CRMP1 CSNK2A1 CYFIP2 FMR1 FXR2 GBP2 KIAA1377 LRIF1 LUC7L2 PRSS23	15 interactors: CYFIP1 CYFIP2 FSD2 FXR1 FXR2 INCA1 MEOX1 NCL NUFIP1 NUFIP2 RANBP9 SPAG5 STAU1 UBE2I YBX1
Entrez ID		8087	2332
HPRD ID		02892	02398
Ensembl ID		ENSG00000114416	ENSG00000102081
Uniprot IDs		B4DXZ6 E9PFF5 P51114	G3V0J0 G8JL90 G8JLE9 Q06787 Q8IXW7 R9WQY1
PDB IDs		2CPQ 3KUF 3O8V	2BKD 2FMR 2LA5 2QND
Enriched GO Terms of Interacting Partners?			Positive Regulation Of SUMO Transferase Activity Negative Regulation Of Translation Positive Regulation Of Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter Positive Regulation By Virus Of Viral Protein Levels In Host Cell Box C/D SnoRNP Assembly Posttranscriptional Regulation Of Gene Expression Regulation Of Cellular Process Sclerotome Development CRD-mediated MRNA Stabilization Somite Specification Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Positive Regulation Of Actin Nucleation Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase I Promoter Intracellular MRNA Localization Chromosome Segregation Positive Regulation Of Macromolecule Biosynthetic Process Hematopoietic Stem Cell Differentiation Positive Regulation Of Gene Expression Regulation Of Gene Expression
Tagcloud ?		address adhesion arm comprised coprecipitated cytoplasm cytoplasmic desmoplakin desmosomes destabilized g3bp gain mrnas outside pabpc1 particles pkp1 pkp2 pkp3 plakophilins posttranscriptional regulators repeat ribonucleoprotein rnase serve stabilized unaffected upf1	17beta cav1 caveolae caveolin cgg cingulate copyright coupling demonstration electrophysiological eralpha facilitation fear fmrp fragile fxs glua1 inherited interacted ko plasticity potentiation raft recording rescued reserved retardation rights shrna
Tagcloud (Difference) ?		address adhesion arm comprised coprecipitated cytoplasm cytoplasmic desmoplakin desmosomes destabilized g3bp gain mrnas outside pabpc1 particles pkp1 pkp2 pkp3 plakophilins posttranscriptional regulators repeat ribonucleoprotein rnase serve stabilized unaffected upf1	17beta cav1 caveolae caveolin cgg cingulate copyright coupling demonstration electrophysiological eralpha facilitation fear fmrp fragile fxs glua1 inherited interacted ko plasticity potentiation raft recording rescued reserved retardation rights shrna
Tagcloud (Intersection) ?