SPSB1 and DDX4

Number of citations of the paper that reports this interaction (PMID 20561531)
9

Data Source:
BioGRID (unspecified method)

		SPSB1	DDX4
Gene Name		splA/ryanodine receptor domain and SOCS box containing 1	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleus Cytoplasm Chromatoid Body Perinuclear Region Of Cytoplasm Pi-body PiP-body
	Molecular Function	Protein Binding	Nucleic Acid Binding Helicase Activity ATP Binding
	Biological Process	Protein Ubiquitination Intracellular Signal Transduction	Male Meiosis I Multicellular Organismal Development Spermatogenesis Gene Expression Sperm Motility Regulation Of Protein Localization PiRNA Metabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	PIWI-interacting RNA (piRNA) biogenesis Regulatory RNA pathways
Drugs
Diseases
GWAS		Dental caries ( 23064961) Immune response to anthrax vaccine ( 22658931) Response to tocilizumab in rheumatoid arthritis ( 22491018)
Protein-Protein Interactions		10 interactors: ATM DDX4 KDM1A MET NOS2 PAWR PRMT1 PRMT6 RASA1 SUV39H1	5 interactors: PIWIL2 RANBP9 SPSB1 SPSB2 SPSB4
Entrez ID		80176	54514
HPRD ID		18106	05593
Ensembl ID		ENSG00000171621	ENSG00000152670
Uniprot IDs		Q96BD6	Q9NQI0
PDB IDs		2JK9 3F2O
Enriched GO Terms of Interacting Partners?		Histone Modification Peptidyl-amino Acid Modification Chromatin Modification Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Organelle Organization RNA Metabolic Process Chromatin Organization Peptidyl-arginine N-methylation Histone H4-R3 Methylation Histone Methylation Negative Regulation Of B Cell Proliferation Histone Arginine Methylation Peptidyl-arginine Methylation Regulation Of Megakaryocyte Differentiation Chromosome Organization Cell Development Protein Methylation Regulation Of RNA Metabolic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Nucleobase-containing Compound Metabolic Process Cellular Protein Modification Process Negative Regulation Of Cellular Metabolic Process Regulation Of Hematopoietic Progenitor Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Immune System Process Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of B Cell Activation Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Response To Hypoxia Regulation Of Cell Death Regulation Of Metabolic Process Developmental Process Nitrogen Compound Metabolic Process Protein Metabolic Process Regulation Of B Cell Proliferation Regulation Of Organelle Organization Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Immune System Process Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Regulation Of Primitive Erythrocyte Differentiation Negative Regulation Of Leukocyte Proliferation Response To Stimulus Cellular Protein Metabolic Process	Protein Ubiquitination Protein Modification By Small Protein Conjugation RNA 5'-end Processing Positive Regulation Of Meiosis I Germ-line Stem Cell Maintenance Regulation Of Meiosis I
Tagcloud ?		attributable contributes define downregulation emphasizes engineered genetically identifies implicating mammary mediator met neu overexpressing pharmacologic positively potentiation preexisting principal principally promoting protect recurrence relapse spontaneously sufficient turn upregulated	122c 2012cb944901 9qh azoospermia blimp1 dazl declare dppa3 envisioned fam122c funds grants hef ikbkg ipsc ipscs lin28 poi poi1 poi2 prdm1 q26 rbmx stella sublines talents vasa xq znf
Tagcloud (Difference) ?		attributable contributes define downregulation emphasizes engineered genetically identifies implicating mammary mediator met neu overexpressing pharmacologic positively potentiation preexisting principal principally promoting protect recurrence relapse spontaneously sufficient turn upregulated	122c 2012cb944901 9qh azoospermia blimp1 dazl declare dppa3 envisioned fam122c funds grants hef ikbkg ipsc ipscs lin28 poi poi1 poi2 prdm1 q26 rbmx stella sublines talents vasa xq znf
Tagcloud (Intersection) ?