KAT6A and HIST3H3

Number of citations of the paper that reports this interaction (PMID 22713874)
12

Data Source:
BioGRID (enzymatic study, pull down, enzymatic study, pull down)

		KAT6A	HIST3H3
Gene Name		K(lysine) acetyltransferase 6A	histone cluster 3, H3
Image
Gene Ontology Annotations	Cellular Component	Nucleosome Nucleus Nucleoplasm Nucleolus Golgi Apparatus PML Body MOZ/MORF Histone Acetyltransferase Complex	Nucleosome Nucleus Nucleoplasm Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Acetyltransferase Activity	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Heart Morphogenesis DNA Packaging Chromatin Organization Nucleosome Assembly Transcription, DNA-templated Protein Acetylation Histone Acetylation Myeloid Cell Differentiation Somatic Stem Cell Maintenance Embryonic Hemopoiesis Aorta Morphogenesis Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Histone H3 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Face Morphogenesis Cellular Senescence	Telomere Maintenance
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	DNA Damage/Telomere Stress Induced Senescence Meiotic recombination Chromosome Maintenance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Mitotic Prophase formation of the beta-catenin:TCF transactivating complex Cellular Senescence Meiotic synapsis Signaling by Wnt Cell Cycle, Mitotic M Phase Telomere Maintenance Packaging Of Telomere Ends TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: AKT1 ATN1 ATXN1 CREBBP H3F3C HIST1H3A HIST1H4A HIST1H4I HIST2H3C HIST3H3 HIST4H4 MAFK PML RERE RUNX1 SPI1 TP53 UBE2U	183 interactors: ADNP AFF1 AHDC1 ANP32A ASF1A ASH2L ATAD2 AURKA AURKB BIRC5 BMI1 BPTF BRD7 C11orf30 C17orf49 CBX1 CBX2 CBX3 CBX4 CBX5 CBX7 CBX8 CCDC101 CDYL CDYL2 CHAF1A CHAF1B CHAMP1 CHD1 CHD4 CHD6 CHUK CREBBP CTBP1 CTBP2 DEK DIDO1 DOT1L DPF2 DPY30 DYRK2 EGFR EHMT1 EHMT2 EP300 ERAP1 EZH2 FOXA1 GADD45A GATAD1 GLYR1 GTF3C4 HAT1 HDAC1 HDAC2 HDAC8 HIRIP3 HMGXB4 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPK HNRNPL HNRNPR ING2 ING4 IRAK1 JADE2 JADE3 JAK1 JAK2 KAT2A KAT2B KAT5 KAT6A KDM1A KDM2A KDM3B KDM5A KDM5D KDM6A KIF2A KIF2C KMT2A KPNA1 LRIF1 LRWD1 MBD3 MCM2 MCM7 MDM2 MEN1 MGA MIER1 MLLT1 MORF4L1 MSL3 MTA1 MTA2 NAP1L4 NCL NCOA2 NCOA3 NOC2L NONO NPM1 NSD1 ORC2 ORC3 ORC4 ORC5 PCGF6 PHC2 PHC3 PHF12 PHF7 PHF8 PIM1 POGZ PPIB PPM1G PRDM2 PRKCA PRKCZ PTBP1 PTMA RAG1 RBBP4 RBBP5 RBBP7 RBP5 RCOR1 RING1 RNF2 RPS6KA3 RPS6KA5 RREB1 SAP30 SET SETD2 SETD7 SETDB1 SFPQ SIN3A SIN3B SMN1 SMNDC1 SMYD3 SUPT20H SUPT3H SUV39H1 SUZ12 TADA1 TADA3 TAF1 TAF10 TAF11 TAF12 TAF13 TAF15 TAF1A TAF2 TAF3 TAF4 TAF4B TAF5 TAF5L TAF6 TAF6L TAF7 TAF8 TAF9 TAF9B TBP TDRD3 TNPO1 TRPM7 UHRF1 VPRBP WHSC1 ZMYM4 ZNF217 ZNF516
Entrez ID		7994	8290
HPRD ID		03244	04156
Ensembl ID		ENSG00000083168	ENSG00000168148
Uniprot IDs		A5PKX7 Q92794	Q16695
PDB IDs		1M36 2LN0 2OZU 2RC4 3V43	2V1D 2YBP 2YBS 3A6N 3T6R
Enriched GO Terms of Interacting Partners?		DNA Methylation On Cytosine Chromatin Silencing At RDNA Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Chromatin Silencing Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA Replication-dependent Nucleosome Assembly Gene Expression Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Chromosome Organization Chromatin Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Methylation Negative Regulation Of Cellular Metabolic Process Histone H4-K20 Demethylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process DNA Modification Regulation Of RNA Metabolic Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Megakaryocyte Differentiation Gene Silencing Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Chromatin Assembly Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Chromatin Assembly Or Disassembly Chromatin Modification Regulation Of Myeloid Cell Differentiation DNA Packaging Organelle Organization Histone Modification Telomere Maintenance DNA Metabolic Process Regulation Of Megakaryocyte Differentiation Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Cell Differentiation Regulation Of Cell Differentiation Nucleocytoplasmic Transport CENP-A Containing Nucleosome Assembly Nuclear Transport DNA Conformation Change Protein Import Into Nucleus	Chromatin Organization Chromatin Modification Chromosome Organization Histone Modification Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Peptidyl-lysine Modification Gene Expression Organelle Organization Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Biosynthetic Process Peptidyl-amino Acid Modification Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Protein Acetylation Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Regulation Of Cellular Process Metabolic Process Histone H3 Acetylation Histone Lysine Methylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Peptidyl-lysine Methylation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression
Tagcloud ?		acetyltransferase aggressive characteristically emu fusing haploinsufficient hence homeobox hox includes localizes lymphoma maintain maintaining maintains malignancy meis1 menin mll1 moz myst3 ncoa3 overlap progenitor progenitors proliferative tale tif2 translocations	alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest ticam1
Tagcloud (Difference) ?		acetyltransferase aggressive characteristically emu fusing haploinsufficient hence homeobox hox includes localizes lymphoma maintain maintaining maintains malignancy meis1 menin mll1 moz myst3 ncoa3 overlap progenitor progenitors proliferative tale tif2 translocations	alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest ticam1
Tagcloud (Intersection) ?