NEIL1 and XRCC1

Number of citations of the paper that reports this interaction (PMID 15260972)
132

Data Source:
HPRD (in vitro)

		NEIL1	XRCC1
Gene Name		nei endonuclease VIII-like 1 (E. coli)	X-ray repair complementing defective repair in Chinese hamster cells 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Microtubule Organizing Center	Nucleus Nucleoplasm
	Molecular Function	Damaged DNA Binding DNA-(apurinic Or Apyrimidinic Site) Lyase Activity Protein C-terminus Binding Zinc Ion Binding Hydrolase Activity, Acting On Glycosyl Bonds DNA N-glycosylase Activity	Damaged DNA Binding Protein Binding Enzyme Binding
	Biological Process	DNA Catabolic Process, Endonucleolytic Base-excision Repair Nucleotide-excision Repair Response To Oxidative Stress Negative Regulation Of Nuclease Activity	Single Strand Break Repair DNA Repair Base-excision Repair
Pathways			Base Excision Repair Resolution of AP sites via the single-nucleotide replacement pathway Resolution of Abasic Sites (AP sites)
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: APP LIG3 POLB XRCC1	16 interactors: APEX1 APLF APTX BRCA1 CSNK2A1 CSNK2A2 LIG3 NEIL1 OGG1 PARP1 PARP2 PCNA PNKP POLB RNF146 SUMO1
Entrez ID		79661	7515
HPRD ID		12314	01909
Ensembl ID		ENSG00000140398	ENSG00000073050
Uniprot IDs		Q96FI4	B2RCY5 P18887 Q59HH7
PDB IDs		1TDH	1CDZ 1XNA 1XNT 2D8M 2W3O 3K75 3K77 3LQC
Enriched GO Terms of Interacting Partners?		Base-excision Repair Neuron Apoptotic Process Neuron Death DNA Repair DNA-dependent DNA Replication DNA Biosynthetic Process Cellular Response To DNA Damage Stimulus Synaptic Growth At Neuromuscular Junction DNA Metabolic Process Response To Stress Collateral Sprouting In Absence Of Injury Base-excision Repair, DNA Ligation Otolith Morphogenesis Collateral Sprouting Axon Midline Choice Point Recognition Base-excision Repair, Gap-filling DNA Replication Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Lagging Strand Elongation Cellular Response To Stress Otolith Development Axon Choice Point Recognition Mitochondrial DNA Repair DNA Ligation Involved In DNA Repair Nucleobase-containing Compound Metabolic Process Neuron Remodeling Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Pyrimidine Dimer Repair DNA Ligation Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Single Strand Break Repair Cellular Copper Ion Homeostasis Mitochondrial DNA Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of DNA Recombination Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA Strand Elongation Involved In DNA Replication Mitochondrial Genome Maintenance Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity DNA Strand Elongation Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Stimulus RNA Polyadenylation	DNA Repair Base-excision Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cellular Response To Stress Nucleotide-excision Repair DNA Catabolic Process Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Stimulus Nitrogen Compound Metabolic Process Response To Stress DNA-dependent DNA Replication DNA Replication Nucleic Acid Phosphodiester Bond Hydrolysis Response To Stimulus Response To Oxidative Stress DNA Catabolic Process, Endonucleolytic Aromatic Compound Catabolic Process Polynucleotide 3' Dephosphorylation Cellular Macromolecule Catabolic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Cellular Metabolic Process Positive Regulation Of DNA Metabolic Process Response To Inorganic Substance DNA Damage Response, Detection Of DNA Damage DNA Recombination Telomere Maintenance Cellular Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Chromosome Organization DNA Ligation Regulation Of Nitrogen Compound Metabolic Process DNA Biosynthetic Process Nucleotide-excision Repair, DNA Gap Filling Catabolic Process Telomere Maintenance Via Semi-conservative Replication Postreplication Repair Single Strand Break Repair Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nuclear DNA Replication Telomere Maintenance Via Recombination Protein ADP-ribosylation Cell Cycle Metabolic Process
Tagcloud ?		absent allowing apex1 arrest arresting brdu bromodeoxyuridine delay excision exerts glycosylase hepatectomy hours incompletely ko ogg1 oxidized oxodgtpase pcna ph proliferating reaching repair restoration seventy udg vital wt	apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd prkcg psg1 pw39 tnnt1
Tagcloud (Difference) ?		absent allowing apex1 arrest arresting brdu bromodeoxyuridine delay excision exerts glycosylase hepatectomy hours incompletely ko ogg1 oxidized oxodgtpase pcna ph proliferating reaching repair restoration seventy udg vital wt	apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd prkcg psg1 pw39 tnnt1
Tagcloud (Intersection) ?