NEIL1 and LIG3

Number of citations of the paper that reports this interaction (PMID 15260972)
132

Data Source:
BioGRID (two hybrid)

		NEIL1	LIG3
Gene Name		nei endonuclease VIII-like 1 (E. coli)	ligase III, DNA, ATP-dependent
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Microtubule Organizing Center	Synaptonemal Complex Nucleus Nucleoplasm Chromosome Mitochondrion DNA Ligase III-XRCC1 Complex
	Molecular Function	Damaged DNA Binding DNA-(apurinic Or Apyrimidinic Site) Lyase Activity Protein C-terminus Binding Zinc Ion Binding Hydrolase Activity, Acting On Glycosyl Bonds DNA N-glycosylase Activity	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding Zinc Ion Binding
	Biological Process	DNA Catabolic Process, Endonucleolytic Base-excision Repair Nucleotide-excision Repair Response To Oxidative Stress Negative Regulation Of Nuclease Activity	DNA Ligation Lagging Strand Elongation DNA Repair Base-excision Repair Base-excision Repair, DNA Ligation Nucleotide-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Mitochondrion Organization Cell Cycle V(D)J Recombination Mitochondrial DNA Repair Negative Regulation Of DNA Recombination Cell Division DNA Biosynthetic Process
Pathways			Base Excision Repair Resolution of AP sites via the single-nucleotide replacement pathway Resolution of Abasic Sites (AP sites)
Drugs			Bleomycin
Diseases
GWAS			QT interval ( 19305408)
Protein-Protein Interactions		4 interactors: APP LIG3 POLB XRCC1	9 interactors: APP JTB NEIL1 PARP1 PNKP TDP1 XRCC1 XRCC5 XRCC6
Entrez ID		79661	3980
HPRD ID		12314	02966
Ensembl ID		ENSG00000140398	ENSG00000005156
Uniprot IDs		Q96FI4	E5KLB5 E5KLB6 P49916
PDB IDs		1TDH	1IMO 1IN1 1UW0 3L2P 3PC7 3PC8 3QVG
Enriched GO Terms of Interacting Partners?		Base-excision Repair Neuron Apoptotic Process Neuron Death DNA Repair DNA-dependent DNA Replication DNA Biosynthetic Process Cellular Response To DNA Damage Stimulus Synaptic Growth At Neuromuscular Junction DNA Metabolic Process Response To Stress Collateral Sprouting In Absence Of Injury Base-excision Repair, DNA Ligation Otolith Morphogenesis Collateral Sprouting Axon Midline Choice Point Recognition Base-excision Repair, Gap-filling DNA Replication Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Lagging Strand Elongation Cellular Response To Stress Otolith Development Axon Choice Point Recognition Mitochondrial DNA Repair DNA Ligation Involved In DNA Repair Nucleobase-containing Compound Metabolic Process Neuron Remodeling Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Pyrimidine Dimer Repair DNA Ligation Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Single Strand Break Repair Cellular Copper Ion Homeostasis Mitochondrial DNA Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of DNA Recombination Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA Strand Elongation Involved In DNA Replication Mitochondrial Genome Maintenance Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity DNA Strand Elongation Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Stimulus RNA Polyadenylation	DNA Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cellular Hyperosmotic Salinity Response Cellular Response To Stress Double-strand Break Repair Cellular Response To X-ray Base-excision Repair Response To Stress Telomere Maintenance Establishment Of Integrated Proviral Latency DNA Damage Response, Detection Of DNA Damage Cellular Hyperosmotic Response Hyperosmotic Salinity Response Establishment Of Viral Latency Cellular Response To Salt Stress Single Strand Break Repair Response To Oxidative Stress Nucleobase-containing Compound Metabolic Process Response To Radiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Cellular Nitrogen Compound Metabolic Process Hyperosmotic Response Cellular Response To Osmotic Stress Response To X-ray Nitrogen Compound Metabolic Process Response To Salt Stress Nucleic Acid Phosphodiester Bond Hydrolysis Cellular Response To Ionizing Radiation Cellular Response To Stimulus DNA Duplex Unwinding DNA Geometric Change Positive Regulation Of Type I Interferon Production Response To Abiotic Stimulus Response To Osmotic Stress Negative Regulation Of Cellular Metabolic Process Nucleotide-excision Repair Regulation Of Type I Interferon Production Synaptic Growth At Neuromuscular Junction Negative Regulation Of Nuclease Activity Polynucleotide 3' Dephosphorylation Homeostatic Process Collateral Sprouting In Absence Of Injury Regulation Of Growth Rate Protein Poly-ADP-ribosylation DNA Catabolic Process Cellular Response To Radiation Response To Stimulus
Tagcloud ?		absent allowing apex1 arrest arresting brdu bromodeoxyuridine delay excision exerts glycosylase hepatectomy hours incompletely ko ogg1 oxidized oxodgtpase pcna ph proliferating reaching repair restoration seventy udg vital wt	ageing ascribes atm attrition brca1 complexity ctip ends fusions homologous instability insufficient joining ku70 lig4 mechanistically nhej overhang parp1 rampant relies repeats telomere telomeres telomeric trf2 unanticipated uncapped underlining
Tagcloud (Difference) ?		absent allowing apex1 arrest arresting brdu bromodeoxyuridine delay excision exerts glycosylase hepatectomy hours incompletely ko ogg1 oxidized oxodgtpase pcna ph proliferating reaching repair restoration seventy udg vital wt	ageing ascribes atm attrition brca1 complexity ctip ends fusions homologous instability insufficient joining ku70 lig4 mechanistically nhej overhang parp1 rampant relies repeats telomere telomeres telomeric trf2 unanticipated uncapped underlining
Tagcloud (Intersection) ?