PRRC2A and PRMT2

Number of citations of the paper that reports this interaction (PMID 14667819)
24

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PRRC2A	PRMT2
Gene Name		proline-rich coiled-coil 2A	protein arginine methyltransferase 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Rb-E2F Complex
	Molecular Function	Protein Binding Poly(A) RNA Binding	Transcription Coactivator Activity Signal Transducer Activity Protein Binding Histone-arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Estrogen Receptor Binding Progesterone Receptor Binding Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Protein Homodimerization Activity Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Thyroid Hormone Receptor Binding Androgen Receptor Binding
	Biological Process		Protein Methylation Signal Transduction Histone Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Negative Regulation Of NF-kappaB Transcription Factor Activity Histone Arginine Methylation Positive Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Developmental Cell Growth Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Drugs
Diseases
GWAS		Menopause (age at onset) ( 22267201) Schizophrenia ( 23894747)
Protein-Protein Interactions		27 interactors: ATN1 ATXN1 C1QBP CCR10 CPSF1 DDX20 EIF3E EWSR1 FGA GANAB GORASP2 GRB2 HNRNPA1 HNRNPM IFT88 IMMT JUN MAD2L2 MAN2C1 P4HA2 PRMT2 PSMA3 QARS RBFOX1 RERE SSR3 UBAP2L	18 interactors: BAG6 CPSF7 DMRTB1 ESR1 ESR2 FIP1L1 HNRNPA1 HNRNPUL1 NCOA1 NCOA6 PGR PRRC2A PSMB3 RB1 RIPK2 RXRA SPAG8 THRB
Entrez ID		7916	3275
HPRD ID		00807	09060
Ensembl ID		ENSG00000204469	ENSG00000160310
Uniprot IDs		P48634	B7U630 B7U631 P55345 Q5U7D4
PDB IDs			1X2P
Enriched GO Terms of Interacting Partners?		Gene Expression MRNA Metabolic Process RNA Splicing RNA Metabolic Process RNA Processing MRNA Processing Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Nucleocytoplasmic Transport Nuclear Transport Heterocycle Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Cytoplasmic Transport MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Signal Transduction In Response To DNA Damage Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of RNA Biosynthetic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Nuclear Export Nuclear Import Negative Regulation Of Protein Metabolic Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading RNA Transport Negative Regulation Of Mitotic Cell Cycle Phase Transition RNA Localization Regulation Of Substrate Adhesion-dependent Cell Spreading Cellular Metabolic Process Ribonucleoprotein Complex Assembly Negative Regulation Of Signal Transduction Glutaminyl-tRNA Aminoacylation Negative Regulation Of Blood Coagulation, Common Pathway Blood Coagulation, Common Pathway Cellular Response To Potassium Ion Starvation Negative Regulation Of DNA Binding Negative Regulation Of Signaling Regulation Of Cell Morphogenesis Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle	Intracellular Receptor Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Gene Expression Transcription Initiation From RNA Polymerase II Promoter Steroid Hormone Mediated Signaling Pathway RNA Metabolic Process DNA-templated Transcription, Initiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Hormone-mediated Signaling Pathway Transcription, DNA-templated Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Cellular Nitrogen Compound Metabolic Process Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Lipid Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Response To Steroid Hormone Multicellular Organismal Reproductive Process Reproductive Structure Development Reproductive System Development Multicellular Organism Reproduction Heterocycle Metabolic Process Response To Lipid Cellular Aromatic Compound Metabolic Process Ovulation Cycle Regulation Of Gene Expression Response To Organic Cyclic Compound Reproductive Process Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Hormone Stimulus Response To Hormone Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Reproduction Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Response To Organic Cyclic Compound Developmental Process Involved In Reproduction Single Organism Reproductive Process Cellular Metabolic Process
Tagcloud ?			bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt3 prmt4 prmt5 prmt6 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized
Tagcloud (Difference) ?			bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt3 prmt4 prmt5 prmt6 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized
Tagcloud (Intersection) ?