PRRC2A and GANAB

Number of citations of the paper that reports this interaction (PMID 14667819)
24

Data Source:
HPRD (two hybrid)

		PRRC2A	GANAB
Gene Name		proline-rich coiled-coil 2A	glucosidase, alpha; neutral AB
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Endoplasmic Reticulum Lumen Golgi Apparatus Membrane Glucosidase II Complex Melanosome Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Poly(A) RNA Binding	Carbohydrate Binding Glucan 1,3-alpha-glucosidase Activity Poly(A) RNA Binding
	Biological Process		Protein Folding Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways			Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases of glycosylation Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective MOGS causes MOGS-CDG (CDG-2b) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) N-glycan trimming in the ER and Calnexin/Calreticulin cycle Defective ALG11 causes ALG11-CDG (CDG-1p) Diseases associated with N-glycosylation of proteins Calnexin/calreticulin cycle
Drugs
Diseases
GWAS		Menopause (age at onset) ( 22267201) Schizophrenia ( 23894747)
Protein-Protein Interactions		27 interactors: ATN1 ATXN1 C1QBP CCR10 CPSF1 DDX20 EIF3E EWSR1 FGA GANAB GORASP2 GRB2 HNRNPA1 HNRNPM IFT88 IMMT JUN MAD2L2 MAN2C1 P4HA2 PRMT2 PSMA3 QARS RBFOX1 RERE SSR3 UBAP2L	7 interactors: CCNH CREB3L4 MAPK8 PRKCSH PRRC2A PTPRC RAP1A
Entrez ID		7916	23193
HPRD ID		00807	03516
Ensembl ID		ENSG00000204469	ENSG00000089597
Uniprot IDs		P48634	B4DIW2 B4DSM6 B4DZ53 E9PKU7 F5H6X6 Q14697
PDB IDs
Enriched GO Terms of Interacting Partners?		Gene Expression MRNA Metabolic Process RNA Splicing RNA Metabolic Process RNA Processing MRNA Processing Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Nucleocytoplasmic Transport Nuclear Transport Heterocycle Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Cytoplasmic Transport MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Signal Transduction In Response To DNA Damage Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of RNA Biosynthetic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Nuclear Export Nuclear Import Negative Regulation Of Protein Metabolic Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading RNA Transport Negative Regulation Of Mitotic Cell Cycle Phase Transition RNA Localization Regulation Of Substrate Adhesion-dependent Cell Spreading Cellular Metabolic Process Ribonucleoprotein Complex Assembly Negative Regulation Of Signal Transduction Glutaminyl-tRNA Aminoacylation Negative Regulation Of Blood Coagulation, Common Pathway Blood Coagulation, Common Pathway Cellular Response To Potassium Ion Starvation Negative Regulation Of DNA Binding Negative Regulation Of Signaling Regulation Of Cell Morphogenesis Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle	Response To Stress Positive Regulation Of Metabolic Process Cellular Response To Stimulus Immunoglobulin Biosynthetic Process Positive Regulation Of Hematopoietic Stem Cell Migration Regulation Of Protein Kinase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Apoptotic Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway JUN Phosphorylation Neurotrophin Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Deacetylase Activity Negative Regulation Of T Cell Mediated Cytotoxicity Regulation Of Protein Phosphorylation Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Isotype Switching To IgG Isotypes Bone Marrow Development Response To Stimulus Positive Regulation Of Cellular Metabolic Process Cell Cycle Phase Transition Positive Regulation Of Determination Of Dorsal Identity Activation Of Protein Kinase Activity Positive Regulation Of Gamma-delta T Cell Differentiation N-glycan Processing Rap Protein Signal Transduction Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Regulation Of Isotype Switching To IgG Isotypes Positive Thymic T Cell Selection Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Gamma-delta T Cell Activation Regulation Of Phosphorylation Negative Regulation Of Protein Autophosphorylation Positive Regulation Of Vasculogenesis Defense Response Cellular Response To Nitric Oxide Nerve Growth Factor Signaling Pathway Regulation Of Gamma-delta T Cell Differentiation Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of T Cell Mediated Immunity Negative Thymic T Cell Selection Signaling Regulation Of Neuron Projection Development Negative Regulation Of Synaptic Vesicle Exocytosis Negative T Cell Selection Response To Nitric Oxide Positive Regulation Of Alpha-beta T Cell Proliferation
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