MAP3K12 and RPL18A

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		MAP3K12	RPL18A
Gene Name		mitogen-activated protein kinase kinase kinase 12	ribosomal protein L18a
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Axon Growth Cone	Cytosol Membrane Cytosolic Large Ribosomal Subunit
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Homodimerization Activity	RNA Binding Structural Constituent Of Ribosome Poly(A) RNA Binding
	Biological Process	Activation Of MAPKK Activity Protein Phosphorylation JNK Cascade Histone Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Intracellular Signal Transduction Protein Autophosphorylation	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process
Pathways			Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: EGFR FRA10AC1 FTL MAP2K4 MAP2K7 MAP3K11 MAPK6 MAPK8IP1 MAPK8IP2 MBIP RGS1 RPL18A SH3RF1 TGM2 TSC22D1	10 interactors: AES JUN LPL MAP3K12 MDK NEDD4 RIBC2 RNF115 RPL36 TNK2
Entrez ID		7786	6142
HPRD ID		02709	16045
Ensembl ID		ENSG00000139625	ENSG00000105640
Uniprot IDs		Q12852	B4DM94 Q02543
PDB IDs			3J3B
Enriched GO Terms of Interacting Partners?		MAPK Cascade Signal Transduction By Phosphorylation Regulation Of JNK Cascade Regulation Of MAPK Cascade Regulation Of Stress-activated MAPK Cascade JNK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of MAP Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Kinase Activity Regulation Of JUN Kinase Activity Regulation Of Phosphorylation Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Death Regulation Of Signaling Regulation Of Protein Phosphorylation Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Catalytic Activity Activation Of JUN Kinase Activity Cellular Response To Sorbitol Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of Kinase Activity Peptidyl-amino Acid Modification Regulation Of Protein Metabolic Process Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Death Positive Regulation Of Transferase Activity Positive Regulation Of Apoptotic Process Activation Of Protein Kinase Activity Positive Regulation Of Programmed Cell Death Cellular Protein Modification Process Positive Regulation Of Protein Serine/threonine Kinase Activity Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Death Cellular Protein Metabolic Process Phosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Phosphorylation Positive Regulation Of JNK Cascade	Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein K63-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Outflow Tract Morphogenesis Establishment Of Protein Localization To Organelle Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Defecation Cellular Response To Potassium Ion Starvation Transmission Of Virus Development Involved In Symbiotic Interaction Protein Targeting Response To Radiation Response To Stress Signal Transduction Negative Regulation Of Binding Response To Drug Protein Localization To Organelle Leading Edge Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Response To Calcium Ion Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Signaling Cell Communication Chylomicron Remodeling Positive Regulation Of Anoikis Regulation Of Signal Transduction Protein Polyubiquitination Cytoplasmic Transport Negative Regulation Of Neuron Apoptotic Process Response To Cytokine Progesterone Receptor Signaling Pathway Positive Regulation Of Monocyte Differentiation Positive Regulation Of Sequestering Of Triglyceride Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stimulus Negative Regulation Of Neuron Death Protein Autophosphorylation Cellular Response To Extracellular Stimulus Regulation Of Signaling Catabolic Process Heart Morphogenesis Cell Surface Receptor Signaling Pathway Glucocorticoid Receptor Signaling Pathway SMAD Protein Import Into Nucleus Very-low-density Lipoprotein Particle Remodeling MAPK Cascade Cellular Macromolecule Catabolic Process
Tagcloud ?		adipocytes adipogenesis adipogenic adipose ascs bisphenol bpa ccaat cebpa disrupter dlk dye ebpalpha esr1 ici igf1 leucine lipase lpl peroxisome physiologically pparg ppargamma precursors proliferator retained temporally visualize zipper
Tagcloud (Difference) ?		adipocytes adipogenesis adipogenic adipose ascs bisphenol bpa ccaat cebpa disrupter dlk dye ebpalpha esr1 ici igf1 leucine lipase lpl peroxisome physiologically pparg ppargamma precursors proliferator retained temporally visualize zipper
Tagcloud (Intersection) ?