MAP3K12 and MAPK6

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		MAP3K12	MAPK6
Gene Name		mitogen-activated protein kinase kinase kinase 12	mitogen-activated protein kinase 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Axon Growth Cone	Nucleus Cytoplasm
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Homodimerization Activity	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Heterodimerization Activity
	Biological Process	Activation Of MAPKK Activity Protein Phosphorylation JNK Cascade Histone Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Intracellular Signal Transduction Protein Autophosphorylation	MAPK Cascade Protein Phosphorylation Cell Cycle Signal Transduction
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: EGFR FRA10AC1 FTL MAP2K4 MAP2K7 MAP3K11 MAPK6 MAPK8IP1 MAPK8IP2 MBIP RGS1 RPL18A SH3RF1 TGM2 TSC22D1	167 interactors: ACTG1 ACTR1B AMPH ANAPC5 ANK3 APBA2 APOA1 APOA1BP ARHGDIA ARPC3 ATG9A ATP5J BAG6 BARX1 BBS10 C21orf59 CA1 CA12 CALR CASP6 CCND3 CCT3 CDH13 CERS1 CFL1 CNTN1 CNTRL COPS6 CSE1L CYTH2 DBN1 DCTN2 DDOST DDR1 DGKZ DKC1 DNAJC28 DPPA4 DSCR3 DST EDF1 EEF1A2 EGLN3 EIF1 EIF3C EIF4A1 ELOF1 EMD FAM49B FBXL16 FOXO3 FXYD3 GALNT7 GATA1 GLRX3 GNB2L1 GORASP1 GPX1 HACL1 HAUS2 HDAC11 HIP1 HNRNPA0 HNRNPD HNRNPH3 HSP90AB1 HSP90B1 HSPD1 IDH3B INS ITGB3BP ITSN1 JUNB KDSR KLC1 KNSTRN LPXN MAP3K12 MAP3K7 MAPKAPK5 MASP1 MBIP MBOAT7 MCM3 MDK METTL17 METTL2A MGAT1 MIPEP MOK MON1A MTG2 MYBL2 MYOZ3 MZB1 NAT9 NDUFS6 NELFB NOL4 NRXN2 NUDT5 OSTF1 PDCD6IP PDLIM1 PHACTR3 PHC2 PHGDH PIH1D1 PLEKHM1 PLK1 PLSCR1 PPBP PPP1R7 PPP2R1A PRKAB1 PRKAR1A PRKCB PRPF38A PSAT1 PSIP1 PTPMT1 PVRL2 RAB2A RAB31 RANBP9 RAP1GAP RARA RBL1 RGS19 RPL10 RRP7A SEPT3 SEPT5 SERPINA4 SHC1 SLC20A1 SLC41A3 SMAD6 SMS SNAPC4 SNW1 SOCS3 SPG7 SPRR2D SPTAN1 SRSF5 STX7 TDP2 THAP4 TPI1 TTK TUBA1A UBA52 UBE2L3 URB1 WDR26 WDR34 WFS1 WWC1 XPO1 ZNF133 ZNF205 ZNF331 ZNF579 ZNF600 ZNF671 ZNF775
Entrez ID		7786	5597
HPRD ID		02709	04213
Ensembl ID		ENSG00000139625	ENSG00000069956
Uniprot IDs		Q12852	Q16659
PDB IDs			2I6L
Enriched GO Terms of Interacting Partners?		MAPK Cascade Signal Transduction By Phosphorylation Regulation Of JNK Cascade Regulation Of MAPK Cascade Regulation Of Stress-activated MAPK Cascade JNK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of MAP Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Kinase Activity Regulation Of JUN Kinase Activity Regulation Of Phosphorylation Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Death Regulation Of Signaling Regulation Of Protein Phosphorylation Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Catalytic Activity Activation Of JUN Kinase Activity Cellular Response To Sorbitol Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of Kinase Activity Peptidyl-amino Acid Modification Regulation Of Protein Metabolic Process Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Death Positive Regulation Of Transferase Activity Positive Regulation Of Apoptotic Process Activation Of Protein Kinase Activity Positive Regulation Of Programmed Cell Death Cellular Protein Modification Process Positive Regulation Of Protein Serine/threonine Kinase Activity Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Death Cellular Protein Metabolic Process Phosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Phosphorylation Positive Regulation Of JNK Cascade	Cell Cycle Cellular Process Organelle Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Mitotic Cell Cycle Cellular Metabolic Process Cell Cycle Process Gene Expression Regulation Of Metabolic Process Regulation Of Catalytic Activity Response To Organic Substance Cellular Component Assembly Regulation Of Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Process Cellular Response To Organic Substance Regulation Of Gene Expression Regulation Of Cellular Component Organization Regulation Of Apoptotic Process Positive Regulation Of Transferase Activity Regulation Of Phosphorus Metabolic Process Regulation Of Immune Response Regulation Of Immune System Process Cellular Macromolecule Biosynthetic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Biosynthetic Process Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Response To Wounding Negative Regulation Of Signal Transduction RNA Metabolic Process Regulation Of Cell Death Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Membrane Organization Positive Regulation Of Phosphorylation Heterocycle Metabolic Process Cell Division RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated
Tagcloud ?		adipocytes adipogenesis adipogenic adipose ascs bisphenol bpa ccaat cebpa disrupter dlk dye ebpalpha esr1 ici igf1 leucine lipase lpl peroxisome physiologically pparg ppargamma precursors proliferator retained temporally visualize zipper	astragalus barbata bcm berry bioflavonoid coptis coriolus dandelion diinodolymethane eleuthero ganoderma knotweed linteus lucidum mycelium nettle nr2f1 palmetto phellinus plau pomegranate prostacaid pumpkin pygeum sarsaparilla scutellaria sitosterolzinc skullcap stinging
Tagcloud (Difference) ?		adipocytes adipogenesis adipogenic adipose ascs bisphenol bpa ccaat cebpa disrupter dlk dye ebpalpha esr1 ici igf1 leucine lipase lpl peroxisome physiologically pparg ppargamma precursors proliferator retained temporally visualize zipper	astragalus barbata bcm berry bioflavonoid coptis coriolus dandelion diinodolymethane eleuthero ganoderma knotweed linteus lucidum mycelium nettle nr2f1 palmetto phellinus plau pomegranate prostacaid pumpkin pygeum sarsaparilla scutellaria sitosterolzinc skullcap stinging
Tagcloud (Intersection) ?