ZBTB17 and DIS3

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
HPRD (two hybrid)

		ZBTB17	DIS3
Gene Name		zinc finger and BTB domain containing 17	DIS3 exosome endoribonuclease and 3-5 exoribonuclease
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytosol Membrane
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Metal Ion Binding	3'-5'-exoribonuclease Activity RNA Binding Endonuclease Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Gastrulation With Mouth Forming Second Transcription, DNA-templated Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Ectoderm Development Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process Negative Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing Gene Expression RRNA Catabolic Process Positive Regulation Of GTPase Activity Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay CUT Catabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		IRE1alpha activates chaperones XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)	Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS		Dilated cardiomyopathy ( 21459883)
Protein-Protein Interactions		19 interactors: CDKN2B CREBBP DIS3 DNMT3A EP300 ESR1 ESR2 GTF2I HCFC1 HK2 HK3 IRF8 ITGB5 MAX MSX2 MYC PGR TMPRSS11A TOPBP1	12 interactors: EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 MPP6 NTMT1 SKIV2L2 ZBTB17
Entrez ID		7709	22894
HPRD ID		04968	06338
Ensembl ID		ENSG00000116809	ENSG00000083520
Uniprot IDs		Q13105	G3V1J5 Q9Y2L1
PDB IDs		2LVR 2LVT 2LVU 2M0D 2M0E 2M0F 2Q81 3M52
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Negative Regulation Of Gene Expression Gene Expression Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Cellular Response To Organic Substance Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Organic Substance Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gland Development N-terminal Peptidyl-lysine Acetylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Rhythmic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Chromatin Modification Multicellular Organismal Development Gland Morphogenesis Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Gene Expression Anatomical Structure Development Mammary Gland Development Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Chromatin Organization Cellular Response To Lipid Positive Regulation Of Cellular Biosynthetic Process Mammary Gland Duct Morphogenesis Branching Morphogenesis Of An Epithelial Tube Mammary Gland Branching Involved In Pregnancy	RRNA Processing RRNA Metabolic Process Ribosome Biogenesis Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Ribonucleoprotein Complex Biogenesis Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay NcRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic RNA Catabolic Process Maturation Of 5.8S RRNA MRNA Metabolic Process Nuclear MRNA Surveillance RNA Surveillance RNA Phosphodiester Bond Hydrolysis Aromatic Compound Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Cellular Macromolecule Catabolic Process RNA Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis DNA Deamination RRNA Catabolic Process Nucleobase-containing Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Catabolic Process Nitrogen Compound Metabolic Process CUT Catabolic Process Histone MRNA Catabolic Process DNA Modification Intracellular MRNA Localization Positive Regulation Of Cell Growth Cellular Metabolic Process Histone MRNA Metabolic Process Positive Regulation Of Growth N-terminal Peptidyl-proline Dimethylation N-terminal Peptidyl-alanine Trimethylation Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription N-terminal Peptidyl-serine Dimethylation N-terminal Peptidyl-serine Trimethylation Regulation Of Cell Growth Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing Metabolic Process
Tagcloud ?		10k 1p35 1p36 aboriginal affymetrix annotated arrangements cataract descent dysmorphism encompasses epha2 ephb2 erythematous harbour lod merlin monosomy overlaps pedigree penetrant positional rash rs1441834 rs966321 ruled segregating spans volkmann	braf copy decisions deletions determining discovered emphasize fam46c heterogeneity heterozygosity homozygous kras massively modeling mutated myeloma nonhyperdiploid nonmutated nras paired parallel partial particularly predicts promotion putative subclonal subclones tp53
Tagcloud (Difference) ?		10k 1p35 1p36 aboriginal affymetrix annotated arrangements cataract descent dysmorphism encompasses epha2 ephb2 erythematous harbour lod merlin monosomy overlaps pedigree penetrant positional rash rs1441834 rs966321 ruled segregating spans volkmann	braf copy decisions deletions determining discovered emphasize fam46c heterogeneity heterozygosity homozygous kras massively modeling mutated myeloma nonhyperdiploid nonmutated nras paired parallel partial particularly predicts promotion putative subclonal subclones tp53
Tagcloud (Intersection) ?