DIS3 and EXOSC5

Number of citations of the paper that reports this interaction (PMID 11719186)
268

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		DIS3	EXOSC5
Gene Name		DIS3 exosome endoribonuclease and 3-5 exoribonuclease	exosome component 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytosol Membrane	Exosome (RNase Complex) Nucleus Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Endonuclease Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing Gene Expression RRNA Catabolic Process Positive Regulation Of GTPase Activity Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay CUT Catabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Defense Response To Virus RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA	Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 MPP6 NTMT1 SKIV2L2 ZBTB17	32 interactors: BIRC2 CALCOCO2 CDK5RAP1 DHRS2 DIS3 DOCK8 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FCHO1 GOLGA2 IKZF3 KIAA1217 KRT13 LIPG LSM5 MPP6 NUP210 PA2G4 PKM POLR2L REL SFPQ SKIV2L2 TNFAIP1 TRIM54 ZNF558
Entrez ID		22894	56915
HPRD ID		06338	16222
Ensembl ID		ENSG00000083520	ENSG00000077348
Uniprot IDs		G3V1J5 Q9Y2L1	M0R050 Q9NQT4
PDB IDs			2NN6
Enriched GO Terms of Interacting Partners?		RRNA Processing RRNA Metabolic Process Ribosome Biogenesis Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Ribonucleoprotein Complex Biogenesis Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay NcRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic RNA Catabolic Process Maturation Of 5.8S RRNA MRNA Metabolic Process Nuclear MRNA Surveillance RNA Surveillance RNA Phosphodiester Bond Hydrolysis Aromatic Compound Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Cellular Macromolecule Catabolic Process RNA Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis DNA Deamination RRNA Catabolic Process Nucleobase-containing Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Catabolic Process Nitrogen Compound Metabolic Process CUT Catabolic Process Histone MRNA Catabolic Process DNA Modification Intracellular MRNA Localization Positive Regulation Of Cell Growth Cellular Metabolic Process Histone MRNA Metabolic Process Positive Regulation Of Growth N-terminal Peptidyl-proline Dimethylation N-terminal Peptidyl-alanine Trimethylation Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription N-terminal Peptidyl-serine Dimethylation N-terminal Peptidyl-serine Trimethylation Regulation Of Cell Growth Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing Metabolic Process	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RRNA Processing RRNA Metabolic Process Ribosome Biogenesis Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay NcRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process Ribonucleoprotein Complex Biogenesis MRNA Catabolic Process RNA Catabolic Process MRNA Metabolic Process RRNA Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic RNA Metabolic Process Maturation Of 5.8S RRNA Nuclear MRNA Surveillance Aromatic Compound Catabolic Process RNA Surveillance Cellular Macromolecule Catabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression RNA Phosphodiester Bond Hydrolysis Cellular Nitrogen Compound Metabolic Process Catabolic Process Nitrogen Compound Metabolic Process Intracellular MRNA Localization Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing Nucleic Acid Phosphodiester Bond Hydrolysis TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' RNA Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) SnoRNA Metabolic Process RRNA 3'-end Processing Cellular Metabolic Process RNA Localization DNA Deamination Immune System Process Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Immune Response Leukocyte Activation Isotype Switching
Tagcloud ?		braf copy decisions deletions determining discovered emphasize fam46c heterogeneity heterozygosity homozygous kras massively modeling mutated myeloma nonhyperdiploid nonmutated nras paired parallel partial particularly predicts promotion putative subclonal subclones tp53
Tagcloud (Difference) ?		braf copy decisions deletions determining discovered emphasize fam46c heterogeneity heterozygosity homozygous kras massively modeling mutated myeloma nonhyperdiploid nonmutated nras paired parallel partial particularly predicts promotion putative subclonal subclones tp53
Tagcloud (Intersection) ?