VRK1 and HIST2H3C

Number of citations of the paper that reports this interaction (PMID 17938195)
28

Data Source:
BioGRID (pull down, enzymatic study)

		VRK1	HIST2H3C
Gene Name		vaccinia related kinase 1	histone cluster 2, H3c
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Stack Spindle Cytosol	Nucleosome Extracellular Region Nucleus Nucleoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Nucleosomal Histone Binding Histone Kinase Activity (H3-S10 Specific) Histone Kinase Activity (H3-T3 Specific)	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Mitotic Cell Cycle Protein Phosphorylation Endocytosis Mitotic Nuclear Division Mitotic Nuclear Envelope Disassembly Mitotic Nuclear Envelope Reassembly Regulation Of Cell Shape Wnt Signaling Pathway Histone H3-S10 Phosphorylation Protein Autophosphorylation Cell Division Histone H3-T3 Phosphorylation Golgi Disassembly	Chromatin Silencing At RDNA Blood Coagulation Gene Expression DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic
Pathways		Mitotic Prophase Nuclear Envelope Breakdown Nuclear Envelope Reassembly Clearance of Nuclear Envelope Membranes from Chromatin Mitotic Anaphase Initiation of Nuclear Envelope Reformation Cell Cycle, Mitotic M Phase Mitotic Metaphase and Anaphase	RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression Factors involved in megakaryocyte development and platelet production PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS		Neutrophil count ( 21507922)
Protein-Protein Interactions		5 interactors: HIST2H2BE HIST2H3C PLK3 SRPK2 TP53	61 interactors: ARID4A ATRX AURKB BIRC5 BRD1 BRD4 BRD7 BRPF1 CDCA8 CDK8 CHUK COPRS DDB2 DNMT3L EHMT2 ELP3 EP300 HDGFRP2 INCENP ING1 JADE1 KAT2A KAT2B KAT5 KAT6A KDM1A KDM2A KDM3A KDM4C KDM6A KMT2A KMT2B KMT2C KMT2D MSL2 MUM1 NAP1L4 NASP NCOA6 NRD1 PHF21A PIM1 PKN1 PRMT6 PTMA RBBP4 RBBP5 RERE RNF20 RNF4 RPS6KA5 SETD1A SETD1B SETD7 SMARCA4 SMYD2 STAT6 TBL1X UHRF1 VRK1 WHSC1
Entrez ID		7443	126961
HPRD ID		03701	11822
Ensembl ID		ENSG00000100749
Uniprot IDs		Q99986	Q71DI3
PDB IDs		2KTY 2KUL 2LAV 3OP5	2IIJ 2X4W 2X4X 2X4Y 3AV1 3DB3 3MO8 3QO2 3R93
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Neuron Apoptotic Process Response To Stress Mitotic G1/S Transition Checkpoint Positive Regulation Of Neuron Death Response To Osmotic Stress Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Nuclear Speck Organization Cellular Response To Oxygen Levels Chromatin Assembly Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Involved In Cellular Response To Hypoxia Chromatin Assembly Or Disassembly Mitotic Cell Cycle Checkpoint Regulation Of Cell Cycle DNA Packaging Golgi Disassembly Endomitotic Cell Cycle Negative Regulation Of Helicase Activity Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Cell Cycle Checkpoint Regulation Of Neuron Apoptotic Process Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Intracellular Transport Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Aging Positive Regulation Of Thymocyte Apoptotic Process DNA Conformation Change Mitochondrial DNA Repair Positive Regulation Of Cell Cycle Organelle Organization Regulation Of Neuron Death Immune Response Response To Hypoxia Regulation Of Mitochondrion Degradation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment Golgi Inheritance Glial Cell Apoptotic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Oxidative Stress-induced Premature Senescence ER Overload Response Regulation Of Apoptotic Process Negative Regulation Of Macroautophagy Stress-induced Premature Senescence Regulation Of Cell Death DNA Methylation On Cytosine	Chromatin Modification Chromatin Organization Histone Modification Chromosome Organization Peptidyl-lysine Modification Organelle Organization Peptidyl-amino Acid Modification Transcription, DNA-templated RNA Biosynthetic Process Cellular Protein Modification Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression RNA Metabolic Process Histone Methylation Gene Expression Peptidyl-lysine Methylation Methylation Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Protein Methylation Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Histone Lysine Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Protein Acetylation Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Protein Metabolic Process Histone H3 Acetylation Positive Regulation Of Cellular Biosynthetic Process Histone H3-K4 Methylation Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression
Tagcloud ?		affects ashkenazi atrophy dead electroporation founder homozygosity hypoplasia impairs infantile jews manifestations microcephaly migration muscular neuronal noncatalytic nonsense origins partly pch pontocerebellar r358x rescues shrna sma threonine utero vaccinia
Tagcloud (Difference) ?		affects ashkenazi atrophy dead electroporation founder homozygosity hypoplasia impairs infantile jews manifestations microcephaly migration muscular neuronal noncatalytic nonsense origins partly pch pontocerebellar r358x rescues shrna sma threonine utero vaccinia
Tagcloud (Intersection) ?