VRK1

Gene Name		vaccinia related kinase 1
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Stack Spindle Cytosol
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Nucleosomal Histone Binding Histone Kinase Activity (H3-S10 Specific) Histone Kinase Activity (H3-T3 Specific)
	Biological Process	Mitotic Cell Cycle Protein Phosphorylation Endocytosis Mitotic Nuclear Division Mitotic Nuclear Envelope Disassembly Mitotic Nuclear Envelope Reassembly Regulation Of Cell Shape Wnt Signaling Pathway Histone H3-S10 Phosphorylation Protein Autophosphorylation Cell Division Histone H3-T3 Phosphorylation Golgi Disassembly
Pathways		Mitotic Prophase Nuclear Envelope Breakdown Nuclear Envelope Reassembly Clearance of Nuclear Envelope Membranes from Chromatin Mitotic Anaphase Initiation of Nuclear Envelope Reformation Cell Cycle, Mitotic M Phase Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS		Neutrophil count ( 21507922)
Protein-protein Interactions		5 interactors: HIST2H2BE HIST2H3C PLK3 SRPK2 TP53
Entrez ID		7443
HPRD ID		03701
Ensembl ID		ENSG00000100749
Uniprot IDs		Q99986
PDB IDs		2KTY 2KUL 2LAV 3OP5
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Neuron Apoptotic Process Response To Stress Mitotic G1/S Transition Checkpoint Positive Regulation Of Neuron Death Response To Osmotic Stress Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Nuclear Speck Organization Cellular Response To Oxygen Levels Chromatin Assembly Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Involved In Cellular Response To Hypoxia Chromatin Assembly Or Disassembly Mitotic Cell Cycle Checkpoint Regulation Of Cell Cycle DNA Packaging Golgi Disassembly Endomitotic Cell Cycle Negative Regulation Of Helicase Activity Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Cell Cycle Checkpoint Regulation Of Neuron Apoptotic Process Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Intracellular Transport Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Aging Positive Regulation Of Thymocyte Apoptotic Process DNA Conformation Change Mitochondrial DNA Repair Positive Regulation Of Cell Cycle Organelle Organization Regulation Of Neuron Death Immune Response Response To Hypoxia Regulation Of Mitochondrion Degradation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment Golgi Inheritance Glial Cell Apoptotic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Oxidative Stress-induced Premature Senescence ER Overload Response Regulation Of Apoptotic Process Negative Regulation Of Macroautophagy Stress-induced Premature Senescence Regulation Of Cell Death DNA Methylation On Cytosine
Tagcloud ?		affects ashkenazi atrophy dead electroporation founder homozygosity hypoplasia impairs infantile jews manifestations microcephaly migration muscular neuronal noncatalytic nonsense origins partly pch pontocerebellar r358x rescues shrna sma threonine utero vaccinia