VASP and FAT1

Number of citations of the paper that reports this interaction (PMID 15148305)
22

Data Source:
BioGRID (pull down)

		VASP	FAT1
Gene Name		vasodilator-stimulated phosphoprotein	FAT atypical cadherin 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Tight Junction Focal Adhesion Actin Cytoskeleton Lamellipodium Membrane Filopodium Membrane Extracellular Vesicular Exosome	Nucleus Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Focal Adhesion Lamellipodium Filopodium Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding	Calcium Ion Binding Protein Binding
	Biological Process	Neural Tube Closure Axon Guidance Actin Polymerization Or Depolymerization Positive Regulation Of Actin Filament Polymerization Cell Junction Assembly T Cell Receptor Signaling Pathway Protein Homotetramerization	Actin Filament Organization Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Establishment Or Maintenance Of Cell Polarity Cell-cell Signaling Anatomical Structure Morphogenesis Single Organismal Cell-cell Adhesion Cell Migration
Pathways		Cell junction organization TCR signaling Generation of second messenger molecules Axon guidance Signaling by Robo receptor Cell-extracellular matrix interactions Adaptive Immune System
Drugs
Diseases
GWAS			Obesity ( 21552555)
Protein-Protein Interactions		36 interactors: ABI1 ABI2 ABI3 ACTA1 ACTG1 APBB1 APBB1IP DMRTB1 DNMBP ERMAP FAT1 FGFR1OP FYB GSN LPP NOL3 NR4A1 PFN1 PFN2 PLSCR1 PRKACA PRKG1 PRPF40A RAPH1 SAT1 SCGB2A2 SPTA1 TES TRIM9 VCL WAS WASL WWP2 XIRP1 XPO6 ZYX	4 interactors: ENAH HOMER1 HOMER3 VASP
Entrez ID		7408	2195
HPRD ID		03415	02986
Ensembl ID		ENSG00000125753	ENSG00000083857
Uniprot IDs		P50552	Q14517
PDB IDs		1EGX 1JNG 1USD 1USE 2PAV 2PBD 3CHW
Enriched GO Terms of Interacting Partners?		Actin Cytoskeleton Organization Actin Filament-based Process Cytoskeleton Organization Actin Filament Organization Movement Of Cell Or Subcellular Component Response To Wounding Organelle Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Actin Polymerization Or Depolymerization Blood Coagulation Positive Regulation Of Actin Nucleation Wound Healing Hemostasis Platelet Activation Positive Regulation Of Cytoskeleton Organization Anatomical Structure Morphogenesis Regulation Of Actin Cytoskeleton Organization Cell Development Locomotion Negative Regulation Of Protein Complex Assembly Regulation Of Body Fluid Levels Regulation Of Actin Filament-based Process Negative Regulation Of Actin Filament Polymerization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cell Projection Organization Regulation Of Actin Nucleation Regulation Of Cytoskeleton Organization Negative Regulation Of Protein Polymerization Regulation Of Cellular Component Organization Regulation Of Cellular Process Positive Regulation Of ATPase Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Neuron Projection Development Actomyosin Structure Organization Cell Projection Morphogenesis Positive Regulation Of Organelle Organization Cell Part Morphogenesis Regulation Of ATPase Activity Positive Regulation Of Immune System Process Regulation Of Organelle Organization Anatomical Structure Development Fc Receptor Signaling Pathway Cell Activation Immune Response-regulating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Neuron Development Regulation Of Immune System Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Component Biogenesis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis	Regulation Of Store-operated Calcium Entry G-protein Coupled Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Actin Polymerization Or Depolymerization Neural Tube Closure T Cell Receptor Signaling Pathway Neural Tube Formation Antigen Receptor-mediated Signaling Pathway Embryonic Epithelial Tube Formation Epithelial Tube Formation Tube Formation Morphogenesis Of Embryonic Epithelium Cell Surface Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Glutamate Receptor Signaling Pathway Regulation Of Calcium Ion Transport Neural Tube Development Immune Response-activating Cell Surface Receptor Signaling Pathway Actin Filament Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Tissue Development Epithelial Tube Morphogenesis Axon Guidance Cell Development Tube Morphogenesis Chemical Homeostasis Within A Tissue Immune Response-regulating Signaling Pathway Behavioral Response To Cocaine Signal Transduction Morphogenesis Of An Epithelium Axonogenesis Protein Localization To Synapse Signaling Axon Development Cell Communication Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Actin Cytoskeleton Organization Regulation Of Calcium Ion Import Skeletal Muscle Fiber Development Regulation Of Ion Transport Positive Regulation Of Immune Response Neuron Projection Morphogenesis Actin Filament-based Process Embryonic Morphogenesis Tissue Morphogenesis Skeletal Muscle Contraction Myotube Cell Development Tube Development Cell Morphogenesis Involved In Differentiation Cellular Response To Stimulus
Tagcloud ?		abm acta cardinal colocalize concentrates concentrating factories fppppx gppppp immunolocalization listeria microinjection motile motility perinuclear phosphoprotein profilin rear redistributed rocket shigella tails underscore vaccinia vasodilator vinculin virions xppppp zyxin	bcl11b cadherin discovered dnm2 druggable exhibitedthe fbxw7 frequencies guide harboured herc1 jak jak3 lymphoblastic mll2 mutational notch1 notch2 phf6 recurrent regulators reln secretase splicing subclonal unfavourable warranted wt1 zrsr2
Tagcloud (Difference) ?		abm acta cardinal colocalize concentrates concentrating factories fppppx gppppp immunolocalization listeria microinjection motile motility perinuclear phosphoprotein profilin rear redistributed rocket shigella tails underscore vaccinia vasodilator vinculin virions xppppp zyxin	bcl11b cadherin discovered dnm2 druggable exhibitedthe fbxw7 frequencies guide harboured herc1 jak jak3 lymphoblastic mll2 mutational notch1 notch2 phf6 recurrent regulators reln secretase splicing subclonal unfavourable warranted wt1 zrsr2
Tagcloud (Intersection) ?