VARS and CALCOCO2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		VARS	CALCOCO2
Gene Name		valyl-tRNA synthetase	calcium binding and coiled-coil domain 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Cytosol	Nucleus Cytoplasm Golgi Apparatus Cytoskeleton Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Aminoacyl-tRNA Editing Activity Valine-tRNA Ligase Activity ATP Binding	Protein Binding Protein Homodimerization Activity
	Biological Process	TRNA Aminoacylation For Protein Translation Valyl-tRNA Aminoacylation Regulation Of Translational Fidelity Gene Expression	Viral Process Response To Interferon-gamma
Pathways		Cytosolic tRNA aminoacylation tRNA Aminoacylation
Drugs		L-Valine
Diseases
GWAS
Protein-Protein Interactions		4 interactors: CACNA1A CALCOCO2 EEF1D YWHAQ	143 interactors: ABLIM1 ADSL AES AKAP17A AMMECR1 AP5B1 APEX2 ARHGEF39 ARHGEF5 ARNT2 BAHD1 BCL6B BEX2 C20orf195 CBX8 CCDC185 CCDC33 CCNH CEP57L1 CHCHD3 CPNE7 CWF19L2 DAXX DAZAP2 DBNDD2 DCTN4 DCX DDIT4L DDX6 DOCK2 DUSP12 DUSP26 EEF1E1 ENKD1 EXOSC5 FAM107A FAM161A FAM168A FAM189A2 FAM90A1 FARS2 FASTK FBF1 FBXL18 FKBPL FXR2 GABARAPL1 GABARAPL2 GATAD2B GEMIN4 GIT2 GLYCTK HDAC7 HOXB9 IKBKG KANSL1 KAT7 KLHL42 LENG1 LGALS8 LIMS2 LITAF LMF2 LMO2 LMO4 LNX1 LONRF1 LSM4 MAGOHB MAVS MCM10 METTL17 MID2 MOS MTPAP MVP MXI1 MYO6 NAA10 NDN NFU1 ORC5 PAPD4 PCGF1 PEF1 PEG10 PFDN5 PHF1 PIAS4 POLI PPP1R18 PRKAB2 PRPF31 PSMA1 PSME4 PTBP1 PTBP2 RABL6 RB1CC1 RBM15 RHPN1 RIN1 RNF11 RPA2 RPL9 RPS27A RTN4IP1 RTP5 SDCBP SHC1 SLC15A3 SMARCD1 SMCP SNRPB SPATA24 SRI STK16 TAX1BP1 TBC1D22B TBK1 TBRG4 TCEB3B TCL1A TEKT3 TP53RK TRAF2 TRAF4 TRAF6 UBAC2 UBB UBC VARS VPS72 ZC2HC1C ZNF101 ZNF205 ZNF337 ZNF408 ZNF426 ZNF451 ZNF564 ZNF581 ZNF638
Entrez ID		7407	10241
HPRD ID		10362	06846
Ensembl ID		ENSG00000204394	ENSG00000136436
Uniprot IDs		P26640	Q13137
PDB IDs			3VVV 3VVW 4GXL 4HAN
Enriched GO Terms of Interacting Partners?		Neural Nucleus Development Cerebellar Molecular Layer Development Vestibular Nucleus Development Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Gamma-aminobutyric Acid Secretion Regulation Of Acetylcholine Secretion, Neurotransmission Rhythmic Synaptic Transmission Calcium Ion-dependent Exocytosis Of Neurotransmitter Cellular Chloride Ion Homeostasis Gamma-aminobutyric Acid Transport Chloride Ion Homeostasis Negative Regulation Of Hormone Biosynthetic Process Pons Development Cerebellar Purkinje Cell Differentiation Cerebellar Purkinje Cell Layer Morphogenesis Reflex Behavioral Response To Pain Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Neuromuscular Synaptic Transmission Regulation Of Hormone Biosynthetic Process Cerebellar Cortex Formation Regulation Of Establishment Of Protein Localization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Neurotransmitter Metabolic Process Gamma-aminobutyric Acid Signaling Pathway Cell Differentiation In Hindbrain Calcium Ion Import Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Hormone Metabolic Process Cerebellar Purkinje Cell Layer Development Membrane Depolarization During Action Potential Brain Development Substantia Nigra Development Regulation Of Protein Localization Head Development Response To Pain Cerebellar Cortex Morphogenesis Synaptic Transmission, Glutamatergic Sulfur Amino Acid Metabolic Process Musculoskeletal Movement Membrane Organization Calcium Ion-dependent Exocytosis Spinal Cord Motor Neuron Differentiation Anion Homeostasis Regulation Of Signaling Adult Walking Behavior Cerebellum Morphogenesis Receptor Clustering Hindbrain Morphogenesis	RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Type I Interferon Production MRNA Metabolic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Toll-like Receptor 4 Signaling Pathway Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter JNK Cascade Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Protein Modification By Small Protein Conjugation Activation Of MAPK Activity Activation Of Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling Positive Regulation Of Protein Modification Process Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Type I Interferon Production Activation Of NF-kappaB-inducing Kinase Activity Protein Ubiquitination Toll-like Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity G1/S Transition Of Mitotic Cell Cycle Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Mitotic G1 DNA Damage Checkpoint
Tagcloud ?		affymetrix aimps aminoacyl arsn arss atlas atp5c1 cars druggable dtgs fars gbm hsp90aa1 integrative interactors krt10 med12 multiforme nars pard3 pathologically ppis qars rxrb synthetases tcga thra versatility	ad astrocytes atg atgs autophagic autophagy avs beneficial brains clear clearance enhancement expected facilitating flux hippocampal impairment lc3 localized microglia mouse ndp52 p62 phosphorylated plaques reflecting sqstm1 tau vesicles
Tagcloud (Difference) ?		affymetrix aimps aminoacyl arsn arss atlas atp5c1 cars druggable dtgs fars gbm hsp90aa1 integrative interactors krt10 med12 multiforme nars pard3 pathologically ppis qars rxrb synthetases tcga thra versatility	ad astrocytes atg atgs autophagic autophagy avs beneficial brains clear clearance enhancement expected facilitating flux hippocampal impairment lc3 localized microglia mouse ndp52 p62 phosphorylated plaques reflecting sqstm1 tau vesicles
Tagcloud (Intersection) ?