NR1H2 and COL4A5

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		NR1H2	COL4A5
Gene Name		nuclear receptor subfamily 1, group H, member 2	collagen, type IV, alpha 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Extracellular Region Collagen Type IV Trimer Basal Lamina Endoplasmic Reticulum Lumen Neuromuscular Junction
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific Transcription Regulatory Region DNA Binding RNA Polymerase II Transcription Factor Recruiting Transcription Factor Activity DNA Binding Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Zinc Ion Binding Apolipoprotein A-I Receptor Binding Retinoid X Receptor Binding ATPase Binding	Extracellular Matrix Structural Constituent
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Positive Regulation Of Lipid Storage Negative Regulation Of Cholesterol Storage Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Lipid Transport Positive Regulation Of Cholesterol Transport Cholesterol Homeostasis Steroid Hormone Mediated Signaling Pathway Cellular Lipid Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Pinocytosis Positive Regulation Of Lipoprotein Lipase Activity Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of Secretion Of Lysosomal Enzymes Regulation Of Cholesterol Homeostasis	Axon Guidance Neuromuscular Junction Development Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway	Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Laminin interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth
Drugs		(3-{3-[[2-Chloro-3-(Trifluoromethyl)Benzyl](2,2-Diphenylethyl)Amino]Propoxy}Phenyl)Acetic Acid Benzenesulfonyl N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE 1,1,1,3,3,3-HEXAFLUORO-2-{4-[(2,2,2-TRIFLUOROETHYL)AMINO]PHENYL}PROPAN-2-OL
Diseases
GWAS
Protein-Protein Interactions		46 interactors: BAG6 C14orf1 CDKN1A CHD3 COL4A5 CSAD DUSP12 FAF1 FOXO3 HDAC4 HMGXB4 ING3 KDM1A LAMC3 MDFI MED1 MPP1 NCOA3 NCOA6 NCOR1 NCOR2 NPY NR0B2 NRIP1 PCDH17 PRKCA RARA RMI1 ROBO2 RXRA RXRB RXRG SCG5 SIRT1 SMPD1 SORBS2 SPRY2 SRC SUV39H1 TMEM161A UBE2D1 UBE2I VDR VIM YY1 ZXDC	18 interactors: ANTXR2 ANXA7 APP CD93 CDKN1A DAZAP2 DCN FBLN2 FN1 HABP2 MATN2 MMP9 NR1H2 OSM RNF10 SERPINE2 SMN1 TK1
Entrez ID		7376	1287
HPRD ID		02660	02363
Ensembl ID		ENSG00000131408	ENSG00000188153
Uniprot IDs		B4DNM6 F1D8P7 M0R2F9 P55055	A7MBN3 P29400 Q49AM6
PDB IDs		1P8D 1PQ6 1PQ9 1PQC 1UPV 1UPW 3KFC 3L0E 4DK7 4DK8
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA-templated Transcription, Initiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Response To Organic Substance Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Reproductive Structure Development Reproductive System Development System Development Positive Regulation Of Gene Expression Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Response To Hormone Multicellular Organismal Development Cell Differentiation Single Organism Reproductive Process Anatomical Structure Development Developmental Process Involved In Reproduction Developmental Process Reproductive Process Cellular Response To Steroid Hormone Stimulus Signal Transduction Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Cellular Response To Organic Substance Cellular Response To Stimulus Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of RNA Biosynthetic Process Chromatin Organization Response To Stimulus Hormone-mediated Signaling Pathway Regulation Of RNA Metabolic Process Gene Expression Positive Regulation Of Transcription, DNA-templated Signaling	Extracellular Matrix Organization Extracellular Structure Organization Anatomical Structure Development System Development Extracellular Matrix Disassembly Developmental Process Regulation Of Growth Response To Abiotic Stimulus Multicellular Organismal Development Nervous System Development Response To Wounding Response To External Stimulus Negative Regulation Of Transport Hemostasis Reproductive Process Endodermal Cell Differentiation Peptide Cross-linking Generation Of Neurons Mating Regulation Of Body Fluid Levels Behavior Neurogenesis Wound Healing Endoderm Formation Positive Regulation Of High-density Lipoprotein Particle Assembly Seminal Vesicle Epithelium Development Positive Regulation Of Secretion Of Lysosomal Enzymes Positive Regulation Of Pancreatic Juice Secretion Fetal Process Involved In Parturition Dendrite Regeneration Tissue Development Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Negative Regulation Of Cell Proliferation Platelet Degranulation Cell Differentiation Response To Stress Regulation Of Neurogenesis Positive Regulation Of Protein Metabolic Process Cell Morphogenesis Involved In Differentiation Skeletal Muscle Cell Proliferation Synaptic Growth At Neuromuscular Junction Mating Plug Formation Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Endoderm Development Regulation Of Cell Growth Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Ion Transport
Tagcloud ?			alport amplified aras ascending audiological audiometric august autosomal certainly curves descending drop eighty exons fibroblast flat groove hearing impairment inheritance moderate oae recessive sensorineural sequenced sixteen wherein xlas
Tagcloud (Difference) ?			alport amplified aras ascending audiological audiometric august autosomal certainly curves descending drop eighty exons fibroblast flat groove hearing impairment inheritance moderate oae recessive sensorineural sequenced sixteen wherein xlas
Tagcloud (Intersection) ?