COL4A5 and OSM

Number of citations of the paper that reports this interaction (PMID 11711546)
6

Data Source:
HPRD (in vitro)

		COL4A5	OSM
Gene Name		collagen, type IV, alpha 5	oncostatin M
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Type IV Trimer Basal Lamina Endoplasmic Reticulum Lumen Neuromuscular Junction	Extracellular Space
	Molecular Function	Extracellular Matrix Structural Constituent	Cytokine Activity Oncostatin-M Receptor Binding Growth Factor Activity
	Biological Process	Axon Guidance Neuromuscular Junction Development Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process	Positive Regulation Of Acute Inflammatory Response Immune Response Multicellular Organismal Development Peripheral Nervous System Development Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Heat Positive Regulation Of Peptidyl-serine Phosphorylation Oncostatin-M-mediated Signaling Pathway Regulation Of Growth Tyrosine Phosphorylation Of Stat3 Protein Tyrosine Phosphorylation Of Stat5 Protein Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of MAPK Cascade Negative Regulation Of Meiotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Hormone Secretion Behavioral Response To Pain Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Division Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Laminin interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233) Nephropathy ( 21399633)
Protein-Protein Interactions		18 interactors: ANTXR2 ANXA7 APP CD93 CDKN1A DAZAP2 DCN FBLN2 FN1 HABP2 MATN2 MMP9 NR1H2 OSM RNF10 SERPINE2 SMN1 TK1	11 interactors: APP COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 IL6ST LIFR OSMR TNNT1
Entrez ID		1287	5008
HPRD ID		02363	01300
Ensembl ID		ENSG00000188153	ENSG00000099985
Uniprot IDs		A7MBN3 P29400 Q49AM6	P13725
PDB IDs			1EVS
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Anatomical Structure Development System Development Extracellular Matrix Disassembly Developmental Process Regulation Of Growth Response To Abiotic Stimulus Multicellular Organismal Development Nervous System Development Response To Wounding Response To External Stimulus Negative Regulation Of Transport Hemostasis Reproductive Process Endodermal Cell Differentiation Peptide Cross-linking Generation Of Neurons Mating Regulation Of Body Fluid Levels Behavior Neurogenesis Wound Healing Endoderm Formation Positive Regulation Of High-density Lipoprotein Particle Assembly Seminal Vesicle Epithelium Development Positive Regulation Of Secretion Of Lysosomal Enzymes Positive Regulation Of Pancreatic Juice Secretion Fetal Process Involved In Parturition Dendrite Regeneration Tissue Development Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Negative Regulation Of Cell Proliferation Platelet Degranulation Cell Differentiation Response To Stress Regulation Of Neurogenesis Positive Regulation Of Protein Metabolic Process Cell Morphogenesis Involved In Differentiation Skeletal Muscle Cell Proliferation Synaptic Growth At Neuromuscular Junction Mating Plug Formation Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Endoderm Development Regulation Of Cell Growth Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Ion Transport	Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Oncostatin-M-mediated Signaling Pathway Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Movement Of Cell Or Subcellular Component Leukemia Inhibitory Factor Signaling Pathway Generation Of Neurons Neuromuscular Junction Development Neuron Development Neurogenesis Ciliary Neurotrophic Factor-mediated Signaling Pathway Cell Morphogenesis Neuron Differentiation Cell Projection Organization Locomotion Nervous System Development Glomerular Basement Membrane Development Synapse Organization Catabolic Process Cell Development Response To External Stimulus Positive Regulation Of Acute Inflammatory Response Cell Differentiation Anatomical Structure Morphogenesis Glomerulus Development Renal System Development Interleukin-11-mediated Signaling Pathway Regulation Of Acute Inflammatory Response Urogenital System Development Negative Regulation Of Angiogenesis System Development Positive Regulation Of Inflammatory Response Cellular Response To Organic Substance Synaptic Growth At Neuromuscular Junction Interleukin-27-mediated Signaling Pathway Cytokine-mediated Signaling Pathway
Tagcloud ?		alport amplified aras ascending audiological audiometric august autosomal certainly curves descending drop eighty exons fibroblast flat groove hearing impairment inheritance moderate oae recessive sensorineural sequenced sixteen wherein xlas	32d absolute alphabeta antiproliferative antiviral consistent detectably express fibrosarcoma ifn ifns interdependence interferons irs jak jak1 jak2 jaks janus kinases lacking largely neither oncostatin phophorylation phosphatidylinositol requirement stat tyk2
Tagcloud (Difference) ?		alport amplified aras ascending audiological audiometric august autosomal certainly curves descending drop eighty exons fibroblast flat groove hearing impairment inheritance moderate oae recessive sensorineural sequenced sixteen wherein xlas	32d absolute alphabeta antiproliferative antiviral consistent detectably express fibrosarcoma ifn ifns interdependence interferons irs jak jak1 jak2 jaks janus kinases lacking largely neither oncostatin phophorylation phosphatidylinositol requirement stat tyk2
Tagcloud (Intersection) ?