UBE2B and UNC119

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		UBE2B	UNC119
Gene Name		ubiquitin-conjugating enzyme E2B	unc-119 homolog (C. elegans)
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Gene Ontology Annotations	Cellular Component	Chromatin Nuclear Chromatin XY Body Nucleus Replication Fork Cytoplasm Plasma Membrane HULC Complex	Spindle Pole Centrosome Cytosol Intercellular Bridge Spindle Midzone
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity	Protein Binding Lipid Binding
	Biological Process	Protein Polyubiquitination Response To Hypoxia In Utero Embryonic Development DNA Repair Postreplication Repair Maintenance Of Chromatin Silencing Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Spermatogenesis Sperm Axoneme Assembly Response To UV Positive Regulation Of Reciprocal Meiotic Recombination Protein Ubiquitination Cellular Response To Insulin Stimulus Negative Regulation Of Histone Phosphorylation Histone H2A Ubiquitination Response To Drug Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of CAMP-mediated Signaling Protein Stabilization Chiasma Assembly Protein Autoubiquitination Canonical Wnt Signaling Pathway Histone Lysine Demethylation Synaptonemal Complex Organization Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Endocytosis Cytokinesis, Completion Of Separation Synaptic Transmission Visual Perception Phototransduction Lipoprotein Transport Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Clathrin-mediated Endocytosis Negative Regulation Of Caveolin-mediated Endocytosis
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: BIRC2 CDKN1B CNOT4 CRMP1 CTNNB1 HIST2H2AC MED31 PCNA RAD18 RNF20 RNF40 TRIM45 UBA1 UBC UBR1 UBR2 UBR3 UBR5 UNC119	92 interactors: AAGAB ALDH2 AMOT ANKRD24 ANXA1 ANXA3 ANXA7 ARL15 ARL2 ARL3 ARL4D ASH2L BCR BRIX1 BTBD2 C16orf74 CBX8 CCL18 CD247 CD3E CD4 CDC42 CDKN1A CDKN2C CETN3 CKMT2 CKS2 COX17 CYB561D2 EIF2S2 ERH FKBPL FXYD6 FYN GIPC2 GSTM4 HCK HLA-DQA1 HMGB1 HSPB3 HSPE1 ID2 IL5RA ITSN1 KDM1A LAMA4 LCK LIG4 LUC7L2 LYN MAPK10 MAPK8IP2 MPHOSPH6 MRPS12 ORAI2 PAFAH1B3 PAPSS1 PCDHA4 PFN1 PHF10 PIN1 PPA1 PPAP2C PSMD11 PSMD2 PTPRS QTRT1 RAP1B RCC1 RFC5 RGL2 RPA2 RPS6KA5 RUFY3 S100A4 S100A8 SAT1 SEPHS1 SERPINB9 SMN1 SULT1E1 TK1 TP53BP2 TP53I3 TRDMT1 TSC22D1 UBE2B UBE2I UBQLN4 ZAK ZFP64 ZNF24
Entrez ID		7320	9094
HPRD ID		01533	04927
Ensembl ID		ENSG00000119048	ENSG00000109103
Uniprot IDs		P63146	Q13432
PDB IDs		1JAS 1NXA 2Y4W 2YB6 2YBF	3GQQ 3RBQ 4GOJ 4GOK
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Catabolic Process Cellular Response To Leucine Proteolysis Histone Ubiquitination Cellular Protein Modification Process Regulation Of Protein K63-linked Ubiquitination Protein Polyubiquitination Response To Cadmium Ion Response To Leucine Histone H2B Ubiquitination Cellular Response To DNA Damage Stimulus Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Response To Amino Acid Cell Cycle Process Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Protein Metabolic Process Histone Monoubiquitination Regulation Of Histone Modification Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Protein Metabolic Process Positive Regulation Of Wnt Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Negative Regulation Of TOR Signaling Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Organonitrogen Compound Positive Regulation Of Histone Methylation Regulation Of Nitrogen Compound Metabolic Process Cell Cycle Regulation Of Cellular Protein Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Chromosome Organization Negative Regulation Of Protein Metabolic Process Protein Monoubiquitination Regulation Of Protein Ubiquitination Positive Regulation Of Protein Modification Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Canonical Wnt Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cellular Metabolic Process	T Cell Costimulation Regulation Of Catalytic Activity Response To Stress Developmental Process Immune System Process Regulation Of Defense Response To Virus By Virus System Development Anatomical Structure Development Positive Regulation Of Catalytic Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Response To Stimulus Immune Response Regulation Of Apoptotic Process Defense Response Cell Cycle Nervous System Development Regulation Of Cellular Protein Metabolic Process Multicellular Organismal Development Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Intracellular Signal Transduction Regulation Of Protein Metabolic Process Cellular Response To Stimulus Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Transferase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of T Cell Activation Regulation Of Cell Activation Regulation Of Cell Cycle Innate Immune Response Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell-cell Adhesion Leukocyte Differentiation T Cell Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Viral Process Positive Regulation Of Intracellular Signal Transduction Cell Differentiation Positive Regulation Of Metabolic Process Cell Activation
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